Ethylene glycol oligomer modified-sodium alginate for efficiently improving the drug loading and the tumor therapeutic effect

Guo, Hua; Yang, Chan; Hu, Zhenpeng; Wang, Wei; Wu, Yukun; Lai, Quanyong; Yuan, Zhi

doi:10.1039/c3tb20968g

Cited by 13 publications

(3 citation statements)

References 38 publications

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“…A stronger red fluorescence intensity of DOX corresponds to the higher cellular uptake amount of liposomes. After entering the cell, DOX will rapidly localize in the nucleus [49][50][51][52]. Compared with CL-DOX, CH-DOX-L and PEG-DOX-L, PEtOz-DOX-L showed stronger red fluorescence in the nucleus, thus indicating that PEtOz-DOX-L can fuse with the endosomal membrane under the low pH of the endosome, release the DOX into the cytoplasm, and DOX gather in the nucleus.…”

Section: Discussionmentioning

confidence: 93%

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Design and evaluation of pH-sensitive liposomes constructed by poly(2-ethyl-2-oxazoline)-cholesterol hemisuccinate for doxorubicin delivery

Xiu

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

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Section: Discussionmentioning

confidence: 93%

“…In this study, DOX is not only a drug but is also a cellular behavior of tracking [49]. A stronger red fluorescence intensity of DOX corresponds to the higher cellular uptake amount of liposomes.…”

Section: Discussionmentioning

confidence: 97%

Design and evaluation of pH-sensitive liposomes constructed by poly(2-ethyl-2-oxazoline)-cholesterol hemisuccinate for doxorubicin delivery

Xiu

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

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“…In the merged image (Figure 10c), the fluorescence positions were completely overlapping, demonstrating that the released DOX was mainly accumulated in the cell nuclei. These results indicated that the prodrug nanoparticles enabled nucleustargeted DOX delivery, 30 which induced DNA damage and cytotoxicity in the cells. 31…”

Section: ■ Results and Discussionmentioning

confidence: 89%

PEGylated Oxidized Alginate-DOX Prodrug Conjugate Nanoparticles Cross-Linked with Fluorescent Carbon Dots for Tumor Theranostics

Jia

Pei

Zhao

et al. 2016

ACS Biomater. Sci. Eng.

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Theranostic nanomedicine has recently emerged as an appealing approach for tumor chemotherapy. Here, for the first time, fluorescent carbon dots (Cdots) were used as cross-linker for tumor theranostic nanoparticles. Novel theranostic nanoparticles of approximately 27 nm with a doxorubicin (DOX) content of 0.2532 mg/mg (mPEG-OAL-DOX/Cdots) were designed by conjugating DOX onto mPEG-OAL/Cdots nanoparticles that were prepared by cross-linking the PEGylated oxidized alginate (mPEG-OAL) with Cdots. Due to the acid-labile Schiff base conjugating linkage, the theranostic prodrug nanoparticles showed low levels of DOX release in the simulated physiological media, which indicated premature drug leakage could be reduced during body circulation. Interestingly, the in vitro DOX release was triggered in the simulated tumor microenvironment without burst release. MTT assay and CLSM analysis showed that the mPEG-OAL/Cdots nanoparticles were noncytotoxic, but that the mPEG-OAL-DOX/Cdots theranostic nanoparticles exhibited high degrees of inhibition of cancer cells due to their nucleus-targeting DOX delivery. In addition, their cellular fluorescence characteristic demonstrated a potential application for imaging-guided drug delivery in tumor treatment.

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Fabrication of Doxorubicin‐Loaded Glycyrrhetinic Acid‐Biotin‐Starch Nanoparticles and Drug Delivery Into HepG2 Cells In Vitro

et al. 2018

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In this article, amphiphilic self‐assembled glycyrrhetinic acid‐biotin‐starch nanoparticles (GaBS NPs) are fabricated by an N,N′‐dicyclohexylcarbodiimide (DCC)/4‐dimethylaminopyridine (DMAP)‐mediated one‐step esterification reaction, and the physicochemical properties of the prepared self‐assembled NPs are characterized. The self‐assembled GaBS NPs are used as targeted nanocarriers to deliver doxorubicin (DOX) into hepatoma carcinoma cells (HepG2 cells). The drug release profile, cytotoxicity, cellular uptake, and intracellular distribution of the drug‐loaded NPs are evaluated in vitro. Because of endocytosis mediated by a specific receptor, the DOX/GaBS NPs in three forms of administration exhibit the lowest IC50 value to HepG2 cells. The cellular uptake mechanism of pure DOX and the DOX/GaBS NPs is identified by confocal laser scanning microscopy (CLSM), and the cell internalization of the drug‐loaded NPs is confirmed to be faster than that of pure DOX. The GaBS NPs are considered to have potential as a promising chemotherapeutic drug nanocarrier targeting hepatoma carcinoma cells for reducing side effects to normal tissues.

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Ethylene glycol oligomer modified-sodium alginate for efficiently improving the drug loading and the tumor therapeutic effect

Cited by 13 publications

References 38 publications

Design and evaluation of pH-sensitive liposomes constructed by poly(2-ethyl-2-oxazoline)-cholesterol hemisuccinate for doxorubicin delivery

Design and evaluation of pH-sensitive liposomes constructed by poly(2-ethyl-2-oxazoline)-cholesterol hemisuccinate for doxorubicin delivery

PEGylated Oxidized Alginate-DOX Prodrug Conjugate Nanoparticles Cross-Linked with Fluorescent Carbon Dots for Tumor Theranostics

Fabrication of Doxorubicin‐Loaded Glycyrrhetinic Acid‐Biotin‐Starch Nanoparticles and Drug Delivery Into HepG2 Cells In Vitro

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