Ethylcellulose Applications in Multiparticulate Systems

Rajabi‐Siahboomi, Ali R.; Mehta, Raxit Y.; Ambudkar, Vaibhav; Dias, V. R.; Tiwari, Sandip B.

doi:10.1007/978-1-4939-7012-4_11

Cited by 5 publications

(1 citation statement)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite its wide usages in different pharmaceutical areas as a binder, as a bulk polymer for preparation of microcapsules and microspheres, as film-forming and matrix-forming material for sustained release dosage forms, etc. there is still significant research going on in regards to the EC exploitation for new pharmaceutical commercial applications (Rajabi-Siahboomi et al 2017;Kulterer et al 2012). In the recent years special attention was paid to design new methods for producing polysaccharide nanostructured assemblies that can possess properties that are significantly different from the bulk material (Christine and Ponchel 2017).…”

Section: Introductionmentioning

confidence: 99%

Effect of different surface active polysaccharide derivatives on the formation of ethyl cellulose particles by the emulsion-solvent evaporation method

et al. 2018

View full text Add to dashboard Cite

This paper aims at a better understanding of the systematic production of the ethyl cellulose (EC) particles by using an emulsification-solvent evaporation method in the presence of different polysaccharide derivatives. In particular, the role of different surface active polymers i.e. one ioniccarboxymethyl cellulose, one nonionic-hydroxyethyl cellulose, and two amphiphilic-high molecular weight methyl cellulose and low molecular weight methyl cellulose on EC particle formation was investigated. We have established how individual surface active polysaccharides with varying concentration from 0.1 to 3.0 wt% affect particle size and its distribution, particle shape, surface charge, and particle surface morphology. The interdependencies between surfactant nature and concentration at constant processing parameters and the subsequent nanoto micro-particle characteristics are discussed. It was determined that the particle size, surface morphology, supramolecular structure and surface properties of EC particles, prepared by an emulsion evaporation method can be effectively controlled by the type and concentration of used polysaccharide surfactant yielding spherical particles sizes from 170 nm to the micrometer level with smooth particle surfaces or remarkably a wrinkled surface morphology or ''particle on particle'' structures.

show abstract

Section: Introductionmentioning

confidence: 99%

Effect of different surface active polysaccharide derivatives on the formation of ethyl cellulose particles by the emulsion-solvent evaporation method

et al. 2018

View full text Add to dashboard Cite

show abstract

Structural and Morphological Characterization of Strontium Ferrite-Ethylcellulose Nanocomposite for Application in Membrane Technology

Stajcic

Radović²

2023

Bioceramics, Biomimetic and Other Compatible Materials Features for Medical Applications

View full text Add to dashboard Cite

Development of sustained-release microparticles containing tamsulosin HCl for orally disintegrating tablet using melt-adsorption method

Cho

Min

Hwang

et al. 2018

Drug Deliv. and Transl. Res.

View full text Add to dashboard Cite

In this study, using the melt-adsorption method, we developed sustained-release microparticles containing the potent drug, tamsulosin HCl, for use as orally disintegrating tablets. A high-speed kneading granulator was used, enabling temperature modulation and uniform material distribution. A lipid and ethylcellulose suspension (Surelease®) was applied to retard drug release, and magnesium aluminometasilicate (Neusilin®) was used as adsorbent. Among various lipid candidates for melt-adsorption, beeswax and glyceryl behenate were selected due to their high mechanical strength. Hot stage microscopy and powder X-ray diffraction analysis results showed compatibility between tamsulosin HCl and both lipids. Characteristic adsorption behavior was observed depending on the physicochemical properties of each composition. Especially, the specific surface area of Neusilin® decreased with increasing amounts of Surelease®, attributed to the pore-covering effect of Surelease®, which significantly increased the size of the microparticles after the lipid adsorption. For a Surelease®-to-beeswax ratio 1:50, both the desired particle size distribution and low burst release were achieved. Furthermore, the orally disintegrating tablet containing optimized microparticles had acceptable tablet hardness and rapid disintegration. Herein, the feasibility of melt-adsorption for the preparation of sustained-release microparticles was well demonstrated. With its convenience and efficiency, the proposed method is a promising alternative to conventional methods, which are relatively difficult and time consuming.

show abstract

Ethylcellulose Applications in Multiparticulate Systems

Cited by 5 publications

References 66 publications

Effect of different surface active polysaccharide derivatives on the formation of ethyl cellulose particles by the emulsion-solvent evaporation method

Effect of different surface active polysaccharide derivatives on the formation of ethyl cellulose particles by the emulsion-solvent evaporation method

Structural and Morphological Characterization of Strontium Ferrite-Ethylcellulose Nanocomposite for Application in Membrane Technology

Development of sustained-release microparticles containing tamsulosin HCl for orally disintegrating tablet using melt-adsorption method

Contact Info

Product

Resources

About