Ethyl pyruvate prevents from chronic cerebral hypoperfusion via preserving cognitive function and decreasing oxidative stress, caspase 3 activation and IL-1β level

Özaçmak, Hale Sayan; Özaçmak, Veysel Haktan; TURAN, İnci

doi:10.4149/bll_2018_086

Cited by 4 publications

(4 citation statements)

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“…Our results indicated that MDA on POD1 was an independent risk factor for POCD, strongly suggesting a close association between oxidative stress and POCD. Excessive oxidative stress leads to lipid peroxidation of the cell membranes and the subsequent accumulation of MDA can damage brain cells, which may result in cognitive decline [13]. Pan et al demonstrated that robustly increased hippocampal MDA after surgery was significantly associated with changes in postoperative cognition [42].…”

Section: Discussionmentioning

confidence: 99%

“…However, no consensus has been reached about the relationship between oxidative stress and POCD until now. MDA, a bioactive aldehyde generated by free radical-mediated lipid peroxidation, is an oxidative stress marker [13]. Superoxide dismutase (SOD) is an important enzyme that catalyses the dismutation of superoxide radicals into hydrogen peroxide (H 2 O 2 ) or oxygen (O 2 ) [14].…”

Section: Introductionmentioning

confidence: 99%

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Malondialdehyde on postoperative day 1 predicts postoperative cognitive dysfunction in elderly patients after hip fracture surgery

2019

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Background: Postoperative cognitive dysfunction (POCD) is a great problem for anesthetized subjects and is associated with poor short- and long-term outcomes. We explored promising predictors for POCD in elderly patients after hip fracture surgery. Methods: Elderly subjects (aged ≥65 years) undergoing surgery for hip fracture were consecutively recruited. Neuropsychological assessments were performed 1 day preoperatively (baseline) and 7 days postoperatively, and POCD was defined using the ‘Z scores’ method. Clinical data and laboratory tests were compared between patients with and without POCD development. Binary univariate and multivariate logistic regression analyses were conducted for risk factor assessment. Receiver operating characteristic (ROC) curve analysis was performed to investigate the predictive value of malondialdehyde (MDA) on postoperative day 1 (POD1) for POCD. Results: A total of 198 patients were finally enrolled in the analysis and 51 patients exhibited POCD within 7 postoperative days, with an incidence rate of 25.8%. MDA expression on POD1 (OR: 1.12, 95%CI: 1.03–1.23, P=0.017) was the only independent risk factor for POCD according to the final multivariate logistic regression analysis. ROC curve analysis indicated that MDA on POD1 was a predictor for POCD, with an area under the curve (AUC) of 0.683 and 95%CI of 0.590–0.775 (P<0.001). Conclusions: In conclusion, we demonstrated that MDA on POD1 was an independent risk factor for POCD in elderly subjects undergoing hip fracture surgery.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Malondialdehyde on postoperative day 1 predicts postoperative cognitive dysfunction in elderly patients after hip fracture surgery

2019

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“…It is derived from pyruvate, an important metabolite in the tricarboxylic acid cycle. EP repairs tissue or cell damage and enhances immunity by anti-oxidation and reducing the secretion and expression of inflammatory factors induced by LPS such as IL-1β, IL-6 and IL-8 [11][12][13]. EP also has a therapeutic effect of repairing intestinal barrier on enteritis induced by external stimuli [14].…”

Section: Introductionmentioning

confidence: 99%

Ethyl pyruvate inhibits LPS induced IPEC-J2 inflammation and apoptosis through p38 and ERK1/2 pathways

Dong

Xue

et al. 2019

Cell Cycle

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The endotoxin of Gram-negative bacteria threatens the intestinal health of livestock. Ethyl pyruvate (EP) has been shown to regulate intestinal immunity and protect against cell and tissue damage. In this study, it was first verified that EP could reduce the secretion of IL-8, TNF-α, IL-6 and IL-1β in LPS-induced IPEC-J2 cells. Then, we used RNA sequencing (RNA-seq) to analyze the differentially expressed genes (DEGs) of inflammatory factors induced by LPS in IPEC-J2 cells. It was found that LPS induced the upregulation of 377 genes and the downregulation of 477 genes compared to Vehicle; LPS+EP induced the upregulation of 258 genes and the downregulation of 240 genes compared to Vehicle; and LPS+EP induced the upregulation of 373 genes and the downregulation of 188 genes compared to LPS (fold change > 1.5 and FDR < 0.01). Their enrichment pathways included the MAPK signaling pathway, PI3K-Akt signaling pathway, Tolllike receptor signaling pathway, and other pathways. Furthermore, the mRNA level of cytokines associated with inflammation and apoptosis enriched in the MAPK pathway was verified by qRT-PCR. Western blots and immunofluorescence revealed that EP significantly inhibited phosphorylated p38 and phosphorylated-ERK1/2 protein expression levels (P < 0.05). The apoptosis due to LPS reduced by EP was significantly inhibited, as shown by Annexin V-FITC/PI staining. According to the results, EP inhibited the expression of IL-8, TNF-α, IL-6 and IL-1β as well as apoptosis by inhibiting the phosphorylation of p38 and ERK1/2 in LPS-induced IPEC-J2 cells.

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“…Önceki çalışmalar, kronik serebral hipoperfüzyonun (KSH), beyinde serbest oksijen radikallerinin (OFR) üretilmesi, glial hücrelerin aktivasyonu ve proinflamatuar sitokin yapımının artması yoluyla oksidatif stres ve inflamatuar reaksiyonu tetiklediğini göstermiştir (1)(2)(3)(4).…”

Section: Introductionunclassified

Vasküler Demans Modelinde Çevresel Zenginleştirmenin Depresyon Benzeri Davranış, Kortikal ve Hipokampal BDNF ve IL-1β Seviyeleri Üzerine Etkisi

Çengil¹,

Özaçmak²,

TURAN³

et al. 2019

MJWBS

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Bu çalışma çevresel zenginleştirmenin (EE) kronik serebral hipoperfüzyonla (KSH) oluşturulan vasküler demans modelinde depresyon benzeri davranış, serebral korteks ve hipokampüsde beyin kaynaklı nörotrofik faktör (BDNF), kaspaz-1 ve IL-1β seviyeleri üzerine etkisini incelemek için tasarlanmıştır. Daha önceki çalışmalar EE'nin KSH modelinde oksidatif stres inhibisyonu ve endojen nörokoruyucu faktörlerin artırılmasını içeren yararlı etkilere sahip olduğunu göstermişlerdir. Gereç ve Yöntemler: KSH sıçanlarda bilateral ortak karotid arterlerin oklüzyonu ile oluşturulmuştur. Hayvanlar 3 gruba ayrılmıştır: Sham, standart kafes koşulları ve 4 hafta boyunca zenginleştirilmiş koşullara maruz bırakılan grup. Sükroz tercih testi ve zorlu yüzme testi (FST) KSH sonrası depresif davranışı değerlendirmek için kullanılmıştır. BDNF, IL-1β ve kaspaz-1 düzeylerindeki değişim incelenmiştir. Bulgular: KSH, hipokampüsde BDNF seviyesinde azalmaya, IL-1β ve kaspaz-1 düzeylerinde artış ile birlikte depresyon benzeri davranışa neden olmuştur.. Sonuç: EE serebral hipoperfüzyon durumunda inflamatuar yanıtı azaltarak ve BDNF seviyelerini koruyarak depresif davranışı iyileştirmede farmakolojik olmayan yeni bir strateji olabilir.

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Ethyl pyruvate prevents from chronic cerebral hypoperfusion via preserving cognitive function and decreasing oxidative stress, caspase 3 activation and IL-1β level

Abstract: This study strongly imply that the EP administration can alleviate the memory impairment observed due to CCH. The protection provided by EP may result from inhibition of inflammatory response, apoptotic processes and oxidative stress (Fig. 3, Ref. 58).

Cited by 4 publications

References 51 publications

Malondialdehyde on postoperative day 1 predicts postoperative cognitive dysfunction in elderly patients after hip fracture surgery

Malondialdehyde on postoperative day 1 predicts postoperative cognitive dysfunction in elderly patients after hip fracture surgery

Ethyl pyruvate inhibits LPS induced IPEC-J2 inflammation and apoptosis through p38 and ERK1/2 pathways

Vasküler Demans Modelinde Çevresel Zenginleştirmenin Depresyon Benzeri Davranış, Kortikal ve Hipokampal BDNF ve IL-1β Seviyeleri Üzerine Etkisi

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