Ethyl phosphoramidates of acyclovir: design, synthesis, molecular docking (HN Protein), and evaluation of antiviral and antioxidant activities

Devineni, Subba Rao; Golla, Madhava; Shaik, Thaslim Basha; Janardhan, Avilala; Saddala, Madhu Sudhana; Narasimha, G.; Chamarthi, Naga Raju

doi:10.1007/s00044-017-1819-8

Cited by 4 publications

(1 citation statement)

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“…Previously several researchers proved the NDV inhibitory activity of aminated nucleosides . It was found that amino acid esters are used as pro‐drugs of nucleoside namely Valacyclovir, L ‐valine can easily diffuse across the intestine mediated by the intestinal proton‐coupled peptide transporter which resulted in increase of oral absorption, such as Acyclovir and Ganciclovir …”

Section: Introductionmentioning

confidence: 99%

Synthesis, Spectral Characterization, Docking Studies and Antiviral Activity of Phosphorylated Derivatives of Lopinavir Intermediate

et al. 2019

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Lopinavir (LPV) intermediate, a core unit of the HIV‐protease inhibitor is phosphorylated and screened for their binding efficacy with the Hemagglutinin‐Neuraminidase (HN) protein of Newcastle disease virus (NDV) and of VP7 protein of Bluetongue virus (BTV). The docking simulations were encouraged for their synthesis and screened their antiviral activity against NDV in the Chicken Embryonated eggs. The compounds which have exhibited higher binding energy were selected for antiviral evaluation on target pathogens such as NDV and BTV using in in ovo and in vitro methods. The results revealed that the compounds, 5a, 5b, 5i and 5j showed good activity against NDV and 5a, 5b, 5g and 5j exhibited noble antiviral activity against BTV in both in ovo and in vitro than the remaining title compounds.

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Section: Introductionmentioning

confidence: 99%