Ethyl oleate food-grade O/W emulsions loaded with apigenin: Insights to their formulation characteristics and physico-chemical stability

Abcha, Imen; Souilem, Safa; Neves, Marcos A.; Wang, Zheng; Nefatti, Mohamed; Isoda, Hiroko; Nakajima, Mitsutoshi

doi:10.1016/j.foodres.2018.09.032

Cited by 19 publications

(12 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Besides, the degradations rate of Apig was related with the droplet size of both NEs by compared with the results of DLS. Such a similar finding was also reported on Apig encapsulation in ethyl oleate O/W emulsions [9]. It has been reported that larger droplets surface possibly induced higher diffusion of Apig across the interface, resulting in Apig degradation.…”

Section: Chemical Stability Analysis Of Apig Loaded Into Nanoemulsionssupporting

confidence: 88%

“…To overcome the problem of drug solubility, different carriers such as ethosomes [6], nanoparticle [7], liposomes [8], and O/W emulsions [9] have been introduced to encapsulate Apig. Nevertheless, employing liposomes and ethosomes on drugs may induce unexpected side effects in humans [10,11], and their protectional performances on the chemical stability of Apig are still not very clear.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Encapsulation and Characterization of Nanoemulsions Based on an Anti-oxidative Polymeric Amphiphile for Topical Apigenin Delivery

et al. 2021

View full text Add to dashboard Cite

Apigenin (Apig) is used as a model drug due to its many beneficial bio-activities and therapeutic potentials. Nevertheless, its poor water solubility and low storage stability have limited its application feasibility on the pharmaceutical field. To address this issue, this study developed nanoemulsions (NEs) using an anti-oxidative polymeric amphiphile, d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS), hydrogenated soy lecithin (HL), black soldier fly larvae (BSFL) oil, and avocado (AV) oil through pre-homogenization and ultrasonication method. Addition of TPGS (weight ratios 100 and 50% as compared to HL) into NEs effectively reduced particle size and phase transition region area of NEs with pure HL. Incorporation of Apig into NEs made particle size increase and provided a disorder effect on intraparticle molecular packing. Nevertheless, the encapsulation efficiency of NEs for Apig approached to about 99%. The chemical stability of Apig was significantly improved and its antioxidant ability was elevated by incorporation with BSFL oil and AV oil NEs, especially for NEs with single TPGS. NEs with single TPGS also exhibited the best Apig skin deposition. For future application of topical Apig delivery, NEs-gel was formed by the addition of hyaluronic acid (HA) into NEs. Their rheological characteristics were dominated by the surfactant ratios of HL to TPGS.

show abstract

Section: Chemical Stability Analysis Of Apig Loaded Into Nanoemulsionssupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Encapsulation and Characterization of Nanoemulsions Based on an Anti-oxidative Polymeric Amphiphile for Topical Apigenin Delivery

et al. 2021

View full text Add to dashboard Cite

show abstract

“…There are different AG loaded nano formulations were evaluated for the enhancement of solubility and permeability. The different formulations like nano-crystal ( Al-Shaal et al, 2011 ), phytosomes and nanoemulsion ( Telange et al, 2017 , Abcha et al, 2010 ), polymeric micelles ( Zhai et al, 2013 ). But till date, no literature reported for the formulation of AG loaded BIL for the oral delivery.…”

Section: Introductionmentioning

confidence: 99%

Bioactive Apigenin loaded oral nano bilosomes: Formulation optimization to preclinical assessment

Zafar

Alruwaili

Imam

et al. 2021

Saudi Pharmaceutical Journal

View full text Add to dashboard Cite

Aim Diabetic (type-2) is a metabolic disease characterized by increased blood glucose level from the normal level. In the present study, apigenin (AG) loaded lipid vesicles (bilosomes: BIL) was prepared, optimized and evaluated for the oral therapeutic efficacy. Experimental AG-BIL was prepared by a thin-film evaporation method using cholesterol, span 60 and sodium deoxycholate. The prepared formulation was optimized by 3-factor and 3-level Box-Behnken design using particle size, entrapment efficiency and drug release as a response. The selected formulation further evaluated for ex-vivo permeation, in vivo pharmacokinetic and pharmacodynamics study. Results The optimized AG bilosomes (AG-BILopt) has shown the vesicle size 183.25 ± 2.43 nm, entrapment efficiency 81.67 ± 4.87%. TEM image showed a spherical shape vesicle with sharp boundaries. The drug release study revealed a significant enhancement in AG release (79.45 ± 4.18%) from AG-BILopt as compared to free AG-dispersion (25.47 ± 3.64%). The permeation and pharmacokinetic studies result revealed 4.49 times higher flux and 4.67 folds higher AUC 0-t than free AG-dispersion. The antidiabetic activity results showed significant (P < 0.05) enhancement in therapeutic efficacy than free AG-dispersion. The results also showed marked improvement in biochemical parameters. Conclusion Our findings suggested, the prepared apigenin loaded bilosomes was found to be an efficient delivery in the therapeutic efficacy in diabetes.

show abstract

“…Apigenin-7-O-glucoside is considered as one of the most important phenolic compounds having many physiological functions, including antioxidant, anticancer and antibacterial activities [3]. Recently, apigenin has attracted a great interest in the food industry due to the wide range of its biological activities including antioxidant and anti-inflammatory properties [36]. This compound is also found in significant quantities in parsley, celery, chamomile, oranges, thyme, onions, honey and spices [37].…”

Section: Quantification Of Individual Phenolic Compoundsmentioning

confidence: 99%

Edible Rhus tripartita fruit as source of health-promoting compounds: characterization of bioactive components and antioxidant properties

Abcha

Criado

Salmieri

et al. 2019

Eur Food Res Technol

Self Cite

View full text Add to dashboard Cite

The fruits of Rhus tripartita had recently attracted great attention due to its notable therapeutic effects. Their potential effects are attributed to the richness of diverse classes of secondary metabolites. The objective of this research was to access the determination of chemical composition and antioxidant properties of R. tripartita fruit extracts and its partitioned fractions (absolute petroleum ether, 70% aqueous ethanol, absolute ethyl acetate and water). LC-ESI-MS/MS and FTIR-ATR were used to assess the potential of R. tripartita fruits as a source of health-promoting constituents. A total of 38 phenolics, including flavones, flavonols, flavanones, organic acids, hydroxycinnamic acids and hydroxybenzoic acids, 26 of them were reported for the first time in R. tripartita. The main compounds were apigenin7-O-glucoside, apigenin and p-coumaric acid. The FTIR-ATR analysis results revealed the presence of characteristic functional groups such as − OH, C-O, − C = C and C-H of phenolic compounds, carboxylic acids, carbohydrates, lipophilic components and proteins in R. tripartita fruits. Furthermore, the ethyl acetate fraction showed the highest level of phenolic contents and strong antioxidant activities. The present study recommends R. tripartita fruits as source of natural antioxidants which can be used as bioactive ingredient for functional foods and nutraceuticals.

show abstract

Ethyl oleate food-grade O/W emulsions loaded with apigenin: Insights to their formulation characteristics and physico-chemical stability

Cited by 19 publications

References 78 publications

Encapsulation and Characterization of Nanoemulsions Based on an Anti-oxidative Polymeric Amphiphile for Topical Apigenin Delivery

Encapsulation and Characterization of Nanoemulsions Based on an Anti-oxidative Polymeric Amphiphile for Topical Apigenin Delivery

Bioactive Apigenin loaded oral nano bilosomes: Formulation optimization to preclinical assessment

Edible Rhus tripartita fruit as source of health-promoting compounds: characterization of bioactive components and antioxidant properties

Contact Info

Product

Resources

About