Ethyl-eicosapentaenoate (E-EPA) attenuates motor impairments and inflammation in the MPTP-probenecid mouse model of Parkinson's disease

Luchtman, Dirk; Meng, Qiang; Song, Cai

doi:10.1016/j.bbr.2011.09.033

Cited by 90 publications

(57 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These findings are consistent with the in vivo data showing that the inflammatory response in the cortex and striatum was mitigated in mice on the o-3-enriched diet. The anti-inflammatory characteristics of o-3 PUFAs, such as a decrease in COX-2 expression and cytokines, are consistent with many reported studies [38][39][40] and support the hypothesis that inhibition of acute inflammatory responses may be a viable protective strategy for TBI. The efficacy of o-3 PUFAs against TBI has been reported in a few prior studies.…”

Section: Oligodendrocyte Protection Is Mediated Via Direct Effect Andsupporting

confidence: 88%

Omega-3 Polyunsaturated Fatty Acid Supplementation Improves Neurologic Recovery and Attenuates White Matter Injury after Experimental Traumatic Brain Injury

Guo

Zhang

et al. 2013

J Cereb Blood Flow Metab

100

View full text Add to dashboard Cite

Dietary supplementation with omega-3 (o-3) fatty acids is a safe, economical mean of preventive medicine that has shown protection against several neurologic disorders. The present study tested the hypothesis that this method is protective against controlled cortical impact (CCI). Indeed, mice fed with o-3 polyunsaturated fatty acid (PUFA)-enriched diet for 2 months exhibited attenuated short and long-term behavioral deficits due to CCI. Although o-3 PUFAs did not decrease cortical lesion volume, these fatty acids did protect against hippocampal neuronal loss after CCI and reduced pro-inflammatory response. Interestingly, o-3 PUFAs prevented the loss of myelin basic protein (MPB), preserved the integrity of the myelin sheath, and maintained the nerve fiber conductivity in the CCI model. o-3 PUFAs also directly protected oligodendrocyte cultures from excitotoxicity and blunted the microglial activation-induced death of oligodendrocytes in microglia/oligodendrocyte cocultures. In sum, o-3 PUFAs elicit multifaceted protection against behavioral dysfunction, hippocampal neuronal loss, inflammation, and loss of myelination and impulse conductivity. The present report is the first demonstration that o-3 PUFAs protect against white matter injury in vivo and in vitro. The protective impact of o-3 PUFAs supports the clinical use of this dietary supplement as a prophylaxis against traumatic brain injury and other nervous system disorders.

show abstract

Section: Oligodendrocyte Protection Is Mediated Via Direct Effect Andsupporting

confidence: 88%

Omega-3 Polyunsaturated Fatty Acid Supplementation Improves Neurologic Recovery and Attenuates White Matter Injury after Experimental Traumatic Brain Injury

Guo

Zhang

et al. 2013

J Cereb Blood Flow Metab

100

View full text Add to dashboard Cite

show abstract

“…Similar, but milder, decreased body weights were evident in the MPTPp and TRE + MPTPp groups of Experiment 2. Body weight seems to be rarely reported in studies of MPTPp-induced behavior alterations; however, similar MPTPp-induced weight decreases have been reported by others [44], although this is not always a consistent effect [3].…”

Section: Discussionmentioning

confidence: 83%

Chronic MPTP treatment produces hyperactivity in male mice which is not alleviated by concurrent trehalose treatment

Ferguson

Law

Sarkar

2015

Behavioural Brain Research

View full text Add to dashboard Cite

“…In recent study, DHA administration improved these parameters in MPTP-intoxicated mice as it was seen in the other motor tests. In a previous study it was shown that the diet consisting of regular chow supplemented with 0.8% ethyl-eicosapentaenoate (E-EPA) prolongs the time on the rotarod in MPTP-injected (10 × 25 mg/kg) rats [35].…”

Section: Discussionmentioning

confidence: 99%

Neuronal nitric oxide synthase phosphorylation induced by docosahexaenoic acid protects dopaminergic neurons in an experimental model of Parkinson’s disease

Parlak

Özkan

Dilmaç

et al. 2015

Folia Histochem Cytobiol.

View full text Add to dashboard Cite

Introduction. Docosahexaenoic acid (DHA) has been shown to have beneficial effects on Parkinson's disease (PD). The aim of this study was to investigate if the DHA acts on neurons of substantia nigra (SN) by phosphorylation of neuronal nitric oxide synthase (nNOS) in an experimental mouse model of PD. Material and methods. An experimental model of PD was created by intraperitoneal injections (4 × 20 mg/kg) of the neurotoxin 1-methyl-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP). Three-month-old male C57BL/6 mice were randomly divided into four groups as follows: control (C), DHA-treated (DHA), MPTP-injected (MPTP) and DHA-treated and MPTP-injected (DHA + MPTP). DHA (36 mg/kg/day) was administered daily by gavage for four weeks. Motor activity of the mice was evaluated with pole, locomotor activity and rotarod tests. Caspase-3 activity, nitrate/nitrite and 4-hydroxynonenal (4-HNE) levels were determined by spectrophotometric assays. Immunohistochemistry was used to localize and assess the expressions of tyrosine hydroxylase (TH), nNOS and phospho-nNOS (p-nNOS) in SN.Results. An increased return and total down time in the MPTP group was observed in the pole test, while DHA treatment decreased both parameters. The ambulatory activity, total distance and total locomotor activities were decreased in the MPTP group, whereas they were increased by DHA treatment. MPTP-treated animals exhibited shorter time on the rod test which was significantly increased by DHA treatment. DHA administration significantly decreased 4-HNE and nitrate/nitrite levels of SN supernatants and protected the TH (+) dopaminergic neurons of SN in the DHA + MPTP group compared to the MPTP group. DHA treatment significantly decreased nNOS and increased p-nNOS immunoreactivities in the DHA + MPTP group compared to the MPTP group. Conclusions. These results indicate that DHA treatment protects dopaminergic neurons in SN via increasing nNOS serine 852 phosphorylation in the experimental mice model of PD.

show abstract

Ethyl-eicosapentaenoate (E-EPA) attenuates motor impairments and inflammation in the MPTP-probenecid mouse model of Parkinson's disease

Cited by 90 publications

References 50 publications

Omega-3 Polyunsaturated Fatty Acid Supplementation Improves Neurologic Recovery and Attenuates White Matter Injury after Experimental Traumatic Brain Injury

Omega-3 Polyunsaturated Fatty Acid Supplementation Improves Neurologic Recovery and Attenuates White Matter Injury after Experimental Traumatic Brain Injury

Chronic MPTP treatment produces hyperactivity in male mice which is not alleviated by concurrent trehalose treatment

Neuronal nitric oxide synthase phosphorylation induced by docosahexaenoic acid protects dopaminergic neurons in an experimental model of Parkinson’s disease

Contact Info

Product

Resources

About