Ethyl cellulose nanoparticles: Clarithomycin encapsulation and eradication of H. pylori

Pan-In, Porntip; Banlunara, Wijit; Chaichanawongsaroj, Nuntaree; Wanichwecharungruang, Supason

doi:10.1016/j.carbpol.2014.03.025

Cited by 42 publications

(36 citation statements)

References 17 publications

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“…13,19,[21][22][23][24][25][26][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][62][63][64] Size distribution is particularly important, since narrower distributions favor control of secondary properties such as controllable release rates. Successful nanosphere applications meeting expected performance criteria require largely empirical correlations between measured particle properties and responses in specific applications.…”

Section: Evaluation Of Cellulose-based Nanospheresmentioning

confidence: 99%

“…It was suggested that drug-loaded nanospheres prevented the bacterial infection by adhering to the cell wall, thus restricting bacteria adhesion while also providing sustained drug release. 36 Cellulose nanospheres with covalently bound fluorescent dye molecules were taken up by human fibroblast cells, albeit without any attachment to a selective receptor, and persisted for seven days. Rapid mixing typical of microfluidic processes is likely to exhibit slower, longer-lasting drug release than is observed with similar particles prepared by larger-scale batch mixing.…”

Section: Applicationsmentioning

confidence: 99%

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Cellulose/Cellulose-Based Nanospheres: Perspectives and Prospective

Fei

WinterWilliam

2015

Industrial Biotechnology

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Spherical nanoparticles are attracting increasing interest for diverse commercial uses due to their many useful attributes such as applicability as controlled-release systems and their super-hydrophobicity. In this review, methods of particle formation for cellulose, its derivatives, and related species are discussed with reference to numerous specific examples. Techniques for characterization of particle size, size-distribution, and related properties under both dispersed and solid particle conditions are summarized and contrasted. Finally, we note potential applications for these surprisingly reproducible nanospheres.

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Section: Evaluation Of Cellulose-based Nanospheresmentioning

confidence: 99%

Section: Applicationsmentioning

confidence: 99%

Cellulose/Cellulose-Based Nanospheres: Perspectives and Prospective

Fei

WinterWilliam

2015

Industrial Biotechnology

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“…SEM studies showed the presence of intact ethyl cellulose nanoparticles adhered to the stomach [166]. In a subsequent study, the same group evaluated the potential of clarithromycin-loaded ethyl cellulose nanoparticles for the treatment of H. pylori infection [167]. As anticipated, clarithromycin-loaded ethyl cellulose nanoparticles showed greater efficacy in clearing H. pylori infection in mice compared to clarithromycin suspension.…”

Section: Recent Developments In Targeting Oral Nanoparticles To Spmentioning

confidence: 99%

Nanoparticles for oral delivery: Design, evaluation and state-of-the-art

Date

Hanes

Ensign

2016

Journal of Controlled Release

373

192

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The oral route is a preferred method of drug administration, though achieving effective drug delivery and minimizing off-target side effects is often challenging. Formulation into nanoparticles can improve drug stability in the harsh gastrointestinal (GI) tract environment, providing opportunities for targeting specific sites in the GI tract, increasing drug solubility and bioavailability, and providing sustained release in the GI tract. However, the unique and diverse physiology throughout the GI tract, including wide variation in pH, mucus that varies in thickness and structure, numerous cell types, and various physiological functions are both a barrier to effective delivery and an opportunity for nanoparticle design. Here, nanoparticle design aspects to improve delivery to particular sites in the GI tract are discussed. We then review new methods for evaluating oral nanoparticle formulations, including a short commentary on data interpretation and translation. Finally, the state-of-the-art in preclinical targeted nanoparticle design is reviewed.

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“…Encapsulation of the oil was carried out by solvent precipitation method (Pan-In et al, 2014). Encapsulation of the oil was carried out by solvent precipitation method (Pan-In et al, 2014).…”

Section: Encapsulation Of Fish Oilmentioning

confidence: 99%

“…Semi-purified fish oil with 26% docosahexaenoic acid and 6% eicosapentaenoic acid (TC Union Agrotech, Bangkok, Thailand) was used as polyunsaturated oil in this work. Encapsulation of the oil was carried out by solvent precipitation method (Pan-In et al, 2014). Ethylcellulose (EC, viscosity 250-300 cP; ethoxy content 48%, Sigma-Aldrich, USA, 5.0 g) and fish oil (5.0 g) and butylhydroxytoluene (BHT, Sigma-Aldrich, USA, 0.5 g) were dissolved in 100 mL ethanol.…”

Section: Encapsulation Of Fish Oilmentioning

confidence: 99%

Water‐dispersible microparticles of polyunsaturated oils

Chimpibul

Rengpipat

Wanichwecharungruang

2017

Int J of Food Sci Tech

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Summary Health benefits of polyunsaturated oils are well known; nevertheless, incorporating these oils into food/feed products is not possible due to their chemical instability. Here purified fish oil with 32% (w/w) polyunsaturated fatty acids is co‐encapsulated with the antioxidant butylhydroxyanisole, into 1.0 ± 0.7 μm cellulose‐based microspheres by solvent precipitation method, at the fish oil loading content of 41% and encapsulation efficiency of 81%. Aqueous suspension of the encapsulated fish oil particles shows significantly improved oxidative stability, thermal stability, photostability and shelf‐life stability. Dry powder of the fish oil particles shows excellent shelf‐life stability. Double bond functionality of the encapsulated oil can tolerate high production temperature such as the shrimp feed production process (95 °C for 10 min) or spray dry process (outlet temperature of 120 °C). This encapsulation strategy using biocompatible cellulose polymer should enable effective and versatile applications of polyunsaturated oils in foods, feeds and cosmetics.

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Ethyl cellulose nanoparticles: Clarithomycin encapsulation and eradication of H. pylori

Cited by 42 publications

References 17 publications

Cellulose/Cellulose-Based Nanospheres: Perspectives and Prospective

Cellulose/Cellulose-Based Nanospheres: Perspectives and Prospective

Nanoparticles for oral delivery: Design, evaluation and state-of-the-art

Water‐dispersible microparticles of polyunsaturated oils

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