Ethyl acetate fraction of Amomum xanthioides improves bile duct ligation-induced liver fibrosis of rat model via modulation of pro-fibrogenic cytokines

Kim, Hyeong-Geug; Han, Jong-Min; Lee, Jin-Seok; Lee, Jong Suk; Son, Chang‐Gue

doi:10.1038/srep14531

Cited by 21 publications

(14 citation statements)

References 44 publications

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“…In addition, the fruit is effective against asthma and also functions as an antiemetic agent (7). Various studies have demonstrated that the seed extract of A. xanthioides (AXE) exerts various pharmacological effects, including hepatoprotective and anti-gastritis effects, and the prevention of diabetes mellitus (8,9). Furthermore, our previous studies demonstrated that seed AXE inhibited immediate-type hypersensitivity by reducing mast cell degranulation (10,11).…”

Section: Anti-inflammatory Effect Of Amomum Xanthioides In a Mouse Atmentioning

confidence: 99%

Anti-inflammatory effect of Amomum xanthioides in a mouse atopic dermatitis model

Choi

Jang

et al. 2017

Molecular Medicine Reports

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Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disorder. The present study investigated the effects of Amomum xanthioides extract (AXE) on AD‑like skin inflammation using a Dermatophagoides farinae extract (DFE) and 2,4‑dinitrochlorobenzene (DNCB)‑induced mouse AD model. Hematoxylin and eosin staining results demonstrated that repeated DFE/DNCB exposure markedly increased the thickening of the dermis and epidermis, in addition to the infiltration of eosinophils and mast cells. However, oral administration of AXE reduced these histopathological alterations in a dose‑dependent manner. Elevated serum histamine, total and DFE‑specific immunoglobulin E (IgE), and IgG2a were also decreased by treatment with AXE. In addition, reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) results demonstrated that the mRNA expression of tumor necrosis factor (TNF)‑α, interferon (IFN)‑γ, interleukin (IL)‑4, IL‑13, IL‑31 and IL‑17A was reduced in ear skin following AXE administration in AD mice. Fluorescence‑activated cell sorting demonstrated that the population of CD4+/IL‑4+, CD4+/IFN‑γ+ and CD4+/IL‑17A+ cells in draining lymph nodes was also significantly decreased in AXE‑treated mice compared with AD mice without AXE treatment. Furthermore, keratinocytes that were stimulated with TNF‑α and IFN‑γ exhibited increased gene expression of pro‑inflammatory cytokines and chemokines, including TNF‑α, IL‑1β, IL‑6, IL‑8, C‑C motif chemokine ligand (CCL)17 and CCL22, as determined by RT‑qPCR. However, upregulation of these genes was reduced by AXE pretreatment. Based on these results, we hypothesize that AXE may be useful in the treatment of allergic skin inflammation, particularly AD.

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Section: Anti-inflammatory Effect Of Amomum Xanthioides In a Mouse Atmentioning

confidence: 99%

Anti-inflammatory effect of Amomum xanthioides in a mouse atopic dermatitis model

Choi

Jang

et al. 2017

Molecular Medicine Reports

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“…Inhibition of matrix metalloproteinases (MMPs) results in reduced ECM degradation 3 . Controlling the activation of HSCs that occurs during hepatic fibrosis may have a therapeutic benefit 4 – 7 .…”

Section: Introductionmentioning

confidence: 99%

“…CCl 4 is a laboratory reagent characterized by toxicity causing liver damage and liver fibrosis and is extensively used in liver-related studies 17 . Bile duct ligature (BDL) impairs bile formation and bile flow, leading to cholestatic liver injury that progresses to hepatic fibrosis and cirrhosis 7 . Animal models of liver cirrhosis are widely used to study the mechanisms underlying liver fibrosis and the effect of various drugs on its progression 18 – 21 .…”

Section: Introductionmentioning

confidence: 99%

Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-β1/Smads and PI3K/Akt pathways

Zhang

et al. 2017

Sci Rep

201

148

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The aim of this study was to investigate the effect of quercetin on hepatic fibrosis, a characteristic response to acute or chronic liver injury. Mice were randomized to bile duct ligation (BDL) or carbon tetrachloride (CCl4) cirrhosis models. Quercetin (100 mg/kg or 200 mg/kg daily) was administered by gavage for 2 or 4 weeks. Liver tissue and blood samples were collected for histological and molecular analysis. The results of our experiments showed that quercetin reduced BDL or CCl4 liver fibrosis, inhibited extracellular matrix formation, and regulated matrix metallopeptidase (MMP)-9 and tissue inhibitor of metalloproteinase (TIMP)-1. Quercetin attenuated liver damage by suppressing the TGF-β1/Smads signaling pathway and activating the PI3K/Akt signaling pathway to inhibit autophagy in BDL- or CCl4- induced liver fibrosis. Quercetin prevented hepatic fibrosis by attenuating hepatic stellate cell activation and reducing autophagy through regulating crosstalk between the TGF-β1/Smads and PI3K/Akt pathways.

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“…This formula evidenced the hepatoprotective and anti-hepatofibrotic effects in dimethylnitrosamine-induced chronic hepatic injury rat model and non-alcoholic steatohepatitis mouse model Lee et al, 2018). Those three medicinal plants also have been proved to have the hepatoprotective effects or antioxidative property in animal-based experiments (Han et al, 2012;Kim et al, 2014;Kim et al, 2015).…”

Section: Introductionmentioning

confidence: 88%

“…xanthioides was also reported from a chronic liver injury model (Wang et al, 2013). Furthermore, S. miltiorrhiza showed the neuroprotective actions against the psychological stress (Kim et al, 2015). Quercitrin, a main chemical compound in CG plus was known to modulate macrophage activity by inhibition of peroxynitrite production (Kim et al, 2007).…”

Section: A B C Dmentioning

confidence: 99%

An Herbal Formula CGplus Ameliorates Stress-Induced Hepatic Injury in a BALB/c Mouse Model

Kim

Lee

et al. 2020

Front. Pharmacol.

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Introduction: Stress is a well-known factor for inflammation in diverse organs/tissues. Stress also leads to liver injury, which was supported by clinical observations and animal studies. We herein investigated the hepatoprotective property of an herbal formula (called as CG plus) consisting of Artemisia gmelinii Weber ex Stechm. (syn, Artemisia iwayomogi Kitamura), Wurfbainia villosa var. xanthioides (Wall. ex Baker) Skornick. & A.D.Poulsen (syn, Amomum xanthioides Wallich), and Salvia miltiorrhiza Bunge against stress-induced hepatic damage. Methods: Male BALB/c mice were orally administered water extract of CG plus (0, 50, 100, or 200 mg/kg) daily for 5 days, and then subjected to immobilization stress for 6 h on the 5 th day. Results: Acute immobilization stress elevated remarkably serum concentrations of stress hormones (corticosterone and adrenaline) and two hepatic injury parameters (ALT and AST), while these alterations were significantly attenuated by the administration of CG plus. The increases of oxidative parameters (ROS, NO, lipid peroxidation, and protein carbonyl) and deviation of IL-1b and IL-10 in opposite directions in hepatic tissues were significantly normalized by CG plus. Pre-treatment with CG plus also notably ameliorated the abnormal activation of toll-like receptor 4 (TLR4), CD14, and lipopolysaccharide-binding protein (LPB) as well as infiltration of neutrophils in hepatic tissues. Conclusion: These results suggest that an herbal formula (CG plus) derived from traditional pharmaceutical theory has a potent protective effect against stress-induced hepatic injury via regulation of pro-(IL-1b) and anti-inflammatory (IL-10) cytokines.

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Ethyl acetate fraction of Amomum xanthioides improves bile duct ligation-induced liver fibrosis of rat model via modulation of pro-fibrogenic cytokines

Cited by 21 publications

References 44 publications

Anti-inflammatory effect of Amomum xanthioides in a mouse atopic dermatitis model

Anti-inflammatory effect of Amomum xanthioides in a mouse atopic dermatitis model

Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-β1/Smads and PI3K/Akt pathways

An Herbal Formula CGplus Ameliorates Stress-Induced Hepatic Injury in a BALB/c Mouse Model

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