Ethyl 3-[7-(N-acetyl-4-methoxybenzenesulfonamido)-3-chloro-2H-indazol-2-yl]propionate

Abstract

In the title compound, C21H22ClN3O6S, the fused five- and six-membered ring rings are almost perpendicular to the planes through the atoms forming the acetyl and the propionic ester groups, as indicated by the dihedral angles of 80.3 (2) and 88.3 (7)°, respectively. The dihedral angle between the indazole system and the 4-meth­oxy­benzene­sulfonyl group is 13.76 (6)°. The carbonyl O atom is split over two positions in a 0.60 (5):0.40 (5) ratio. In the crystal, mol­ecules are linked by C—H⋯O and C—H⋯N inter­actions into a three-dimensional network.

Crystallographic study, biological assessment and POM/Docking studies of pyrazoles-sulfonamide hybrids (PSH): Identification of a combined Antibacterial/Antiviral pharmacophore sites leading to in-silico screening the anti-Covid-19 activity

“…The X-ray measurement conditions, crystal data and structure refinement details are summarized in table S1. The selected interatomic distances and angles listed in table S2 are close to those observed in the structures of similar compounds [31] , [32] , [33] . The plot of the molecular structure of the title compound is shown in figure 3 .…”