Ethosomes: A novel drug carrier

Chauhan, Neha; Vasava, Parul; Khan, Sharuk L.; Siddiqui, Falak A.; Islam, Fahadul; Chopra, Hitesh; Emran, Talha Bin

doi:10.1016/j.amsu.2022.104595

Cited by 28 publications

(16 citation statements)

References 23 publications

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“…The two dispersions were mixed after dissolving the drug in water or ethanol. 18 The foreseeable size of vesicles can be fulfilled by sonication, and extrusion. 19…”

Section: Modified Hot Methods Pathmentioning

confidence: 99%

“…In this method, two dispersions were heated separately to 40°C, the first mixture is composed of phospholipid dispersion and the second one is composed of propylene glycol and ethanol. The two dispersions were mixed after dissolving the drug in water or ethanol 18 . The foreseeable size of vesicles can be fulfilled by sonication, and extrusion 19 …”

Section: Preparations Of Ethosomesmentioning

confidence: 99%

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Unlocking the potential of cosmetic dermal delivery with ethosomes: A comprehensive review

Abu‐Huwaij

Zidan

2023

J of Cosmetic Dermatology

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BackgroundIn a world where hair loss, acne, and skin whitening are common concerns, ethosomes emerge as a captivating breakthrough in cosmetic drug delivery.MethodThis review provides a comprehensive overview of the ethosomal system and assesses its potential as an effective nanocarrier for delivering active ingredients to the skin. The focus is on exploring their applications in various pathologies, particularly skin disorders such as acne, hair loss, and skin pigmentation.ResultsEthosomes are a novel type of vesicular nanocarrier composed of high concentrations of ethanol (20‐45%) and phospholipids. Their unique structure and composition make them an ideal choice for transporting active ingredients through the skin, offering targeted and effective treatment. The inclusion of ethanol in ethosomes' composition gives them distinctive properties, including flexibility, deformability, and stability, facilitating deep penetration into the skin and enhancing medication deposition. Moreover, ethosomes improved theoverall drug‐loading capacity, and specificity of target treatmentConclusionEthosomes represent a unique and suitable approach for delivering active cosmetic ingredients in the treatment of hair loss, acne, and skin whitening, presenting a versatile alternative to traditional dermal delivery systems. Despite the challenges associated with their complex preparation and sensitivity to temperature and humidity, the remarkable potential benefits of ethosomes cannot be ignored. Further research is crucial to unlock their full potential, understand their limitations, and refine their formulations and administration methods. Ethosomes hold the promise of transforming the way we address these cosmetic concerns, offering an exciting glimpse into the future of advanced skincare solutions.

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“…The two dispersions were mixed after dissolving the drug in water or ethanol. 18 The foreseeable size of vesicles can be fulfilled by sonication, and extrusion. 19…”

Section: Modified Hot Methods Pathmentioning

confidence: 99%

Section: Preparations Of Ethosomesmentioning

confidence: 99%

Unlocking the potential of cosmetic dermal delivery with ethosomes: A comprehensive review

Abu‐Huwaij

Zidan

2023

J of Cosmetic Dermatology

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“…Additionally, the latter can be classified as small (20–100 nm), large (>100 nm), and giant (>1000 nm) [ 59 , 60 ]. They can be classified into different types such as ethosomes [ 61 ], binary ethosomes [ 62 ], transethosomes [ 63 ], niosomes [ 64 ], glycosomes [ 65 ], and others [ 66 , 67 ] based on the modifications in their lipid membrane composition. Changes in the structure of lipid bilayer lead to improved stability or skin permeability compared to traditional liposomes [ 68 ].…”

Section: Nanoparticle-based Delivery Systemsmentioning

confidence: 99%

Fisetin—In Search of Better Bioavailability—From Macro to Nano Modifications: A Review

Szymczak,

Cielecka-Piontek

2023

IJMS

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As secondary plant metabolites, polyphenols are abundant in fruits and vegetables. They are in high demand because of their many health benefits. However, their low bioavailability makes them complex compounds to use for therapeutic purposes. Due to the limited solubility of phytocompounds, dietary supplements made from them may only be partially effective. Such molecules include fisetin, found in strawberries, and have shown great promise in treating Alzheimer’s disease and cancer. Unfortunately, because of their limited water solubility, low absorption, and poor bioavailability, the assistance of nanotechnology is required to allow them to fulfil their potential fully. Here, we provide evidence that nanodelivery methods and structure modifications can improve fisetin bioavailability, which is linked to improvements in therapeutic efficacy. An open question remains as to which nanocarrier should be chosen to meet the abovementioned requirements and be able to enhance fisetin’s therapeutic potential to treat a particular disease.

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“…As a result, ethanol allows the drug to penetrate further into the epidermis. On the other hand, ethanol gives a negative charge to autosomes, reduces the estimation of vesicles and finally increases the bioavailability of the drugs [ 82 ].…”

Section: Introductionmentioning

confidence: 99%

Lipid-based nanoparticles as a promising treatment for the skin cancer

Golestani

2024

Heliyon

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Ethosomes: A novel drug carrier

Cited by 28 publications

References 23 publications

Unlocking the potential of cosmetic dermal delivery with ethosomes: A comprehensive review

Unlocking the potential of cosmetic dermal delivery with ethosomes: A comprehensive review

Fisetin—In Search of Better Bioavailability—From Macro to Nano Modifications: A Review

Lipid-based nanoparticles as a promising treatment for the skin cancer

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