Ethosome formulation of contact allergens may enhance patch test reactions in patients<sup>*</sup>

Vogel, Stefan; Karlberg, Ann‐Therése; Simonsson, Carl; Johansen, Jeanne Duus; Andersen, Klaus Ejner

doi:10.1111/j.1600-0536.2010.01779.x

Cited by 10 publications

(3 citation statements)

References 19 publications

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“…In recent years, formulations with ethosomes have been used to increase the uptake of active components in topical formulations. This can also increase the uptake of fragrance chemicals and other constituents in such products, as has been shown both experimentally and clinically [112][113][114][115]. In these studies, encapsulating contact allergens in ethosomes gave an increase in the challenge response compared to the same concentrations in an ethanol/water base without ethosomes.…”

Section: Exposurementioning

confidence: 74%

Fragrance Allergens, Overview with a Focus on Recent Developments and Understanding of Abiotic and Biotic Activation

2016

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Fragrances and fragranced formulated products are ubiquitous in society. Contact allergies to fragrance chemicals are among the most common findings when patch-testing patients with suspected allergic contact dermatitis, as well as in studies of contact allergy in the general population. The routine test materials for diagnosing fragrance allergy consist mainly of established mixes of fragrance compounds and natural extracts. The situation is more complex as several fragrance compounds have been shown to be transformed by activation inside or outside the skin via abiotic and/or biotic activation, thus increasing the risk of sensitization. For these fragrance chemicals, the parent compound is often non-allergenic or a very weak allergen, but potent sensitizers will be formed which can cause contact allergy. This review shows a series of fragrance chemicals with well-documented abiotic and/or biotic activation that are indicative and illustrative examples of the general problem. Other important aspects include new technologies such as ethosomes which may enhance both sensitization and elicitation, the effect on sensitization by the mixtures of fragrances found in commercial products and the effect of antioxidants. A contact allergy to fragrances may severely affect quality of life and many patients have multiple allergies which further impact their situation. Further experimental and clinical research is needed to increase the safety for the consumer.

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Section: Exposurementioning

confidence: 74%

Fragrance Allergens, Overview with a Focus on Recent Developments and Understanding of Abiotic and Biotic Activation

2016

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“…Care must be taken that new topical formulations will not increase the formation and uptake of sensitizing oxidation products. Ethosomes, which are used to enhance the uptake of active components in topical formulations, have also been shown to enhance the uptake of fragrance chemicals .…”

Section: Clinical Relevance and Exposurementioning

confidence: 99%

Oxidation products and the skin – the effect of hydroperoxides

Karlberg

2017

Contact Dermatitis

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“…Ethosome is superior to other vesicular systems. It can hold more drugs, penetrate deeper into the skin, trap molecules of varying lipophilicity, and are non-toxic for both in vivo and in vitro studies (42)(43)(44)(45)(46). Ethosome is effective in occlusive and non-occlusive conditions and works well for dermal, transdermal, and intracellular delivery.…”

Section: Introduction Background and Rationale {6a}mentioning

confidence: 99%

A randomised clinical trial study assessing the efficacy of 5% losartan potassium loaded in ethosomal gel based on POSAS 3.0 score, degree of erythema and pigmentation, surface area, thickness and pliability of human keloids: a study protocol

Anggraini,

Trisnowati,

Martien

et al. 2023

Preprint

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Background: Keloid is a skin disorder that results from excessive fibrous tissue growth in the area of the initial trauma. Treating keloids can be challenging since the success of various treatments varies from one study to another. Triamcinolone acetonide injection, a standard treatment, can cause undesirable side effects. Meanwhile, the effectiveness of existing topical therapies for keloids is not always reliable. The pro-inflammatory, pro-proliferative, and pro-fibrotic effects of angiotensin II in human skin contribute to keloid formation. Losartan potassium, an angiotensin II blocker, has the potential to act as an anti-keloid agent. Due to the thicker skin structure of a keloid and ease of application, ethosome gel is chosen as a safe and comfortable carrier for losartan potassium, making it a good choice for treating keloids. Methods: In this randomised clinical trial, 46 adults with keloids were divided into two treatment groups. One group of 23 participants received 5% losartan potassium loaded in ethosomal gel, while the other group of 23 participants received intralesional injections of 10% triamcinolone acetonide. Over 12 weeks, changes in POSAS 3.0 scores, erythema and pigmentation, surface area, thickness, and pliability of the keloids will be measured at four different times: baseline, four weeks, eight weeks, and twelve weeks. Statistical analysis will be conducted using SPSS software version 24, with a significance level of p<0.05. Discussion: Losartan potassium is believed to be beneficial for keloid management because it inhibits the angiotensin II receptor, which plays a role in inflammation, proliferation, and fibrosis. This study aims to examine the efficacy of 5% losartan potassium loaded in ethosomal gel for human keloids. Trial registration: Clinicaltrial.gov identifier NCT05893108. Registered on 7 June 2023.

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Ethosome formulation of contact allergens may enhance patch test reactions in patients^*

Abstract: Encapsulating potential contact allergens in ethosomes may increase the challenge response as compared with the same concentrations in an ethanol/water base without ethosomes.

Cited by 10 publications

References 19 publications

Fragrance Allergens, Overview with a Focus on Recent Developments and Understanding of Abiotic and Biotic Activation

Fragrance Allergens, Overview with a Focus on Recent Developments and Understanding of Abiotic and Biotic Activation

Oxidation products and the skin – the effect of hydroperoxides

A randomised clinical trial study assessing the efficacy of 5% losartan potassium loaded in ethosomal gel based on POSAS 3.0 score, degree of erythema and pigmentation, surface area, thickness and pliability of human keloids: a study protocol

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Ethosome formulation of contact allergens may enhance patch test reactions in patients*

Abstract: Encapsulating potential contact allergens in ethosomes may increase the challenge response as compared with the same concentrations in an ethanol/water base without ethosomes.

Cited by 10 publications

References 19 publications

Fragrance Allergens, Overview with a Focus on Recent Developments and Understanding of Abiotic and Biotic Activation

Fragrance Allergens, Overview with a Focus on Recent Developments and Understanding of Abiotic and Biotic Activation

Oxidation products and the skin – the effect of hydroperoxides

A randomised clinical trial study assessing the efficacy of 5% losartan potassium loaded in ethosomal gel based on POSAS 3.0 score, degree of erythema and pigmentation, surface area, thickness and pliability of human keloids: a study protocol

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Ethosome formulation of contact allergens may enhance patch test reactions in patients^*