Ethological comparison of the effects of a bovine αs1-casein tryptic hydrolysate and diazepam on the behaviour of rats in two models of anxiety

Violle, Nicolas; Messaoudi, Michaël; Lefranc‐Millot, Catherine; Desor, Didier; Nejdi, Amine; Demagny, Benoit; Schroeder, Henri

doi:10.1016/j.pbb.2006.06.017

Cited by 43 publications

(44 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recently, it was discovered that a tryptic hydrolysate from bovine S1-casein, containing a decapeptide [ S1-casein (f91-100) termed -casozepine], displayed anxiolyticlike effects in rats [42,43] and improves sleep in rats subjected to chronic mild stress [44]. In healthy human volunteers, this tryptic hydrolysate showed anxiolytic-like effects, without side effects, on the basis of hemodynamic parameters under mentally and physically stressful situations [45].…”

Section: Introductionmentioning

confidence: 99%

Effects of a Bovine Alpha S1-Casein Tryptic Hydrolysate (CTH) on Sleep Disorder in Japanese General Population

Saint-Hilaire¹,

Messaoudi²,

Desor³

et al. 2009

TOSLPJ

Self Cite

View full text Add to dashboard Cite

This study describes the effect of bovine alpha-S1 casein tryptic hydrolysate (CTH) in a representative sample of day-time workers from the general population of Japan with the occurrence of insomnia during the preceding six months. To investigate this issue, 32 subjects, aged between 25 and 40 years, were examined for the subjective sleep quality using the Japanese Pittsburg Sleep Quality Index (PSQI-J).CTH significantly improves the PSQI total score of the treated subjects. It particularly improves the sleep quality after two weeks of treatment, decreases the sleep latency and the daytime dysfunction after four weeks of treatment.Given the antistress properties of CTH, it seems possible to relate the detected improvement of sleep aspects to a reduction of stress following its' chronic administration.In conclusion, being given its beneficial effects and its absence of negative side effects, it would be advantageous to use the CTH to improve chronic insomnia in the Japanese general population. However, further studies will be necessary in order to clarify the essential aspect of CTH properties in the sleep problems.

show abstract

Section: Introductionmentioning

confidence: 99%

Effects of a Bovine Alpha S1-Casein Tryptic Hydrolysate (CTH) on Sleep Disorder in Japanese General Population

Saint-Hilaire¹,

Messaoudi²,

Desor³

et al. 2009

TOSLPJ

Self Cite

View full text Add to dashboard Cite

show abstract

“…Alpha-casozepine, which is a decapeptide corresponding to the 91-100 fragment of the bovine alpha (s1)-casein, has an anxiolytic-like activity through the GABA A receptor in rats (Miclo et al, 2001;Violle et al, 2006). Moreover, a large number of opioid receptor ligands are derived from milk casein.…”

Section: Discussionmentioning

confidence: 99%

Influences of Casein Hydrolysate Ingestion on Cerebral Activity, Autonomic Nerve Activity, and Anxiety

Nakamura

Iwamoto

Washida

et al. 2010

J Physiol Anthropol

View full text Add to dashboard Cite

This study examined the influences of the oral ingestion of casein hydrolysate from bovine milk at rest physiologically and psychologically. Eleven male university students were given a casein hydrolysate drink (H) or a maltitol drink as a control (C) in a crossover study. Just before and one hour after ingestion of each drink, the total-hemoglobin (tHb) concentrations at ten points of the prefrontal cortex to evaluate cerebral activity, and heart rate variability (HRV) to evaluate autonomic nerve activity through spectral analysis were measured as physiological indicators. The Japanese version of the State-Trait Anxiety Inventory-state anxiety (STAI-s) score was also used, as a psychological indicator. In comparison between H and C ingestion, a significant difference is observed only in tHb concentrations at one of ten points. At this point, the change in tHb concentration was lower after H ingestion compared to C ingestion. And in comparison between before and after ingestion of each drink, a significant increase in tHb concentration at two points after C ingestion, a significant increase in parasympathetic activity and decrease in sympathetic activity after H ingestion, and a significant decrease in STAI-s score in H ingestion were observed. These results suggest that ingestion of the casein hydrolysate may keep prefrontal cortex activity stable while maltitol ingestion partially increases the activity. Moreover, there is a possibility that casein hydrolysate might decrease sympathetic activity, increase parasympathetic activity, and lower anxiety. We conclude that the bovine milk casein hydrolysate may have more relaxing effects than maltitol.

show abstract

“…D'autres essais sur des carnivores ont confirmé la sécurité thérapeutique du produit. Les tests précliniques montrent que ce décapeptide donne des résultats significatifs comparables à ceux du diazépam comparativement à un placebo, mais sans exprimer d'effet désinhibiteur sur le comportement [34,36]. Par ailleurs, dans le test de l'évitement passif, la mémoire antérograde des rats n'est pas affectée par la prise de la molécule et nous n'avons observé ni effet sédatif, ni dépendance, ni accoutumance [20,33].…”

Section: Utilisation En Médecine Vétérinaireunclassified

“…L'arrêt brutal ou progressif des BZD expose la moitié des patients au risque de rebond de l'anxiété ou de l'insomnie et/ou à l'apparition d'un syndrome de sevrage [28] : agressivité-irritabilité, symptomatologie pseudogrippale, paresthésies-engourdissement, diarrhées-constipation, insomnie-cauchemars, agoraphobies-phobies, sensation ébrieuse, vertiges et troubles sensitifs, dépression… [8,25,30]. Ainsi, environ un tiers des échecs de tentatives d'arrêt de traitement par BZD est dû L'hydrolysat trypsique de caséine alpha-s1 de lait bovin (HTC) révèle une activité anxiolytique dans les modèles éthologiques d'anxiété de l'enfouissement défensif conditionné (EDC) et du labyrinthe en croix surélevé chez le rat [21,36]. L'HTC montre également une activité anticonvulsivante chez le rat après administration intrapéritonéale de pentylènetétrazole, un antagoniste non-compétitif des récepteurs GABA-A [21].…”

Section: Introductionunclassified

“…Tous ces éléments indiquent un profil benzodiazepine-like de l'alpha-casozépine et une activité anti-stress de l'HTC [12,13,19,20,21,34,36]. L'alpha-casozépine est une molécule active obtenue à partir de la caséine alpha-s1 de lait bovin, sans traitement autre qu'une hydrolyse trypsique, copie du phénomène physiologique naturel se passant chez le nourrisson.…”

Section: Introductionunclassified

See 1 more Smart Citation

Un anxiolytique naturel : l’hydrolysat trypsique de caséine alpha-s1 de lait bovin. Son intérêt en médecine humaine et vétérinaire

Bénézech

Mullens²,

Lalonde

et al. 2009

Annales Médico-psychologiques, revue psychiatrique

View full text Add to dashboard Cite

This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

show abstract

Ethological comparison of the effects of a bovine αs1-casein tryptic hydrolysate and diazepam on the behaviour of rats in two models of anxiety

Cited by 43 publications

References 43 publications

Effects of a Bovine Alpha S1-Casein Tryptic Hydrolysate (CTH) on Sleep Disorder in Japanese General Population

Effects of a Bovine Alpha S1-Casein Tryptic Hydrolysate (CTH) on Sleep Disorder in Japanese General Population

Influences of Casein Hydrolysate Ingestion on Cerebral Activity, Autonomic Nerve Activity, and Anxiety

Un anxiolytique naturel : l’hydrolysat trypsique de caséine alpha-s1 de lait bovin. Son intérêt en médecine humaine et vétérinaire

Contact Info

Product

Resources

About