Ethnopharmacology, phytochemistry, and bioactivities of Hieracium L. and Pilosella Hill (Cichorieae, Asteraceae) species

Willer, Johanna; Zidorn, Christian; Juan-Vicedo, Jorge

doi:10.1016/j.jep.2021.114465

Cited by 5 publications

(9 citation statements)

References 133 publications

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“…The research of lipase inhibitors has been investigated in 76 plant species resulting able to inhibit lipases. Among them we report Hieracium and Pilosella , which are two strictly related species diffused as popular remedies of obesity [ 107 ].…”

Section: Resultsmentioning

confidence: 99%

Nutraceuticals and the Network of Obesity Modulators

Ammendola¹,

d’Abusco

2022

Nutrients

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Obesity is considered an increasingly widespread disease in the world population, regardless of age and gender. Genetic but also lifestyle-dependent causes have been identified. Nutrition and physical exercise play an important role, especially in non-genetic obesity. In a three-compartment model, the body is divided into fat mass, fat-free mass and water, and obesity can be considered a condition in which the percentage of total fat mass is in excess. People with a high BMI index or overweight use self-medications, such as food supplements or teas, with the aim to prevent or treat their problem. Unfortunately, there are several obesity modulators that act both on the pathways that promote adipogenesis and those that inhibit lipolysis. Moreover, these pathways involve different tissues and organs, so it is very difficult to identify anti-obesity substances. A network of factors and cells contributes to the accumulation of fat in completely different body districts. The identification of natural anti-obesity agents should consider this network, which we would like to call “obesosome”. The nutrigenomic, nutrigenetic and epigenetic contribute to making the identification of active compounds very difficult. This narrative review aims to highlight nutraceuticals that, in vitro or in vivo, showed an anti-obesity activity or were found to be useful in the control of dysfunctions which are secondary to obesity. The results suggest that it is not possible to use a single compound to treat obesity, but that the studies have to be addressed towards the identification of mixtures of nutraceuticals.

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Section: Resultsmentioning

confidence: 99%

Nutraceuticals and the Network of Obesity Modulators

Ammendola¹,

d’Abusco

2022

Nutrients

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“…Only about 1.5 % of the approximately 5000 members of this genus in the strict sense have been investigated so far for their chemical composition and/or pharmacological activities. [8,9] In most of the previous studies, the aerial parts of the plants were studied. For example, we analysed phenolic acids, flavonoids and sesquiterpene lactones in the dried methanol (MeOH) extracts of the flowering aerial parts (herbs) of 28 Hieracium species (Table S1), the antioxidant activity of all these extracts, the antimicrobial and cytotoxic effects of five, and the antihyperalgesic and antiedematous activities of two extracts.…”

Section: Introductionmentioning

confidence: 99%

“…The greatest species richness has been recorded in western, northern and central Europe, the Alps, and the western Balkan Peninsula especially in Mt Durmitor in Montenegro. Only about 1.5 % of the approximately 5000 members of this genus in the strict sense have been investigated so far for their chemical composition and/or pharmacological activities [8,9] . In most of the previous studies, the aerial parts of the plants were studied.…”

Section: Introductionmentioning

confidence: 99%

Investigation of Anticholinesterase Activity of Chemically Characterised Hieracium s. str. Methanol Extracts and Their Selected Metabolites

Milutinović,

Petrović,

Petković

et al. 2023

Chemistry & Biodiversity

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The composition and anticholinesterase activity of the dried MeOH extracts of Hieracium scheppigianum and H. naegelianum underground parts (rhizomes and roots), as well as the anticholinesterase activity of the dried, previously chemically characterised MeOH extracts of the flowering aerial parts of these two and 26 other Hieracium species in the strict sense (s. str.), were investigated. Furthermore, the anticholinesterase activity of 12 selected secondary metabolites of these extracts was evaluated. Using semi‐preparative LC‐MS, five caffeoylquinic acids and the sesquiterpene lactone crepiside E were isolated from H. scheppigianum underground parts extract. All these compounds were also identified in the underground parts extract of H. naegelianum. Quantitative LC‐MS analysis showed that the analysed underground parts extracts were rich in both caffeoylquinic acids (139.77 and 156.62 mg/g of extract, respectively) and crepiside E (126.88 and 116.58 mg/g). In the Ellman method, the tested extracts showed an interesting anti‐AChE and/or anti‐BChE activity (IC50=0.56‐1.58 mg/mL), which can be explained, at least partially, by the presence of some of their constituents. Among the metabolites tested, the best activity was revealed for the flavonoids apigenin, luteolin and diosmetin, and the sesquiterpene lactone 8‐epiixerisamine A (IC50=68.09‐299.37 μM).

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“…Moreover, for only about 30 Hieracium s. str. species pharmacological activities were tested [2–8] . Regarding antimicrobial and cytotoxic activities, only H. umbellatum L. and H. waldsteinii Tausch extracts were investigated.…”

Section: Introductionmentioning

confidence: 99%

“…species pharmacological activities were tested. [2][3][4][5][6][7][8] Regarding antimicrobial and cytotoxic activities, only H. umbellatum L. and H. waldsteinii TAUSCH extracts were investigated. Non-polar extracts of H. umbellatum roots, leaves and stems were tested against one bacteria and polar extracts of its flowering aerial parts on three cancer cell lines.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial and Cytotoxic Activities of Selected Hieracium L. s. str. (Asteraceae) Extracts and Isolated Sesquiterpene Lactones

Milutinović

Matić

Stanojković

et al. 2022

Chemistry & Biodiversity

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Antimicrobial and cytotoxic activities were tested for dried MeOH extracts of Hieracium calophyllum (CAL), H. coloriscapum (COL), H. pseudoschenkii (PSE), H. valdepilosum (VAL) and H. glabratum (GLA) herbs (flowering aerial parts), their 2 sesquiterpene lactones (SLs) 8‐epiixerisamine A and crepiside E, and dried CH2Cl2 extract of H. scheppigianum (SCH) herb. In microdilution test, extracts showed activity on all tested microorganisms (8 bacteria, 10 fungi). The best effect was exhibited by SCH and CAL on Salmonella Typhimurium (MIC=1.7–2.5 mg/mL MBC=3.4–5.0 mg/mL), and SCH and VAL on Candida albicans (MIC=2.5 mg/mL MFC=5.0 mg/mL). SLs showed notable effect on all tested fungi Aspergillus ochraceus, Penicillium funiculosum, C. albicans and C. krusei (MIC=0.15–0.4 mg/mL MFC=0.3–0.8 mg/mL). In MTT test, extracts inhibited growth of all tested cancer cells (HeLa, LS174 and A549), with the best effect on HeLa (IC50=148.1 μg/mL for SCH, and 152.3–303.2 μg/mL for MeOH extracts); both SLs were active against HeLa cells (IC50=46.2 μg/mL for crepiside E and 103.8 μg/mL for 8‐epiixerisamine A). Extracts and SLs showed good safety profile on normal MRC‐5 cells.

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Ethnopharmacology, phytochemistry, and bioactivities of Hieracium L. and Pilosella Hill (Cichorieae, Asteraceae) species

Cited by 5 publications

References 133 publications

Nutraceuticals and the Network of Obesity Modulators

Nutraceuticals and the Network of Obesity Modulators

Investigation of Anticholinesterase Activity of Chemically Characterised Hieracium s. str. Methanol Extracts and Their Selected Metabolites

Antimicrobial and Cytotoxic Activities of Selected Hieracium L. s. str. (Asteraceae) Extracts and Isolated Sesquiterpene Lactones

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