Ethnopharmacological uses, phytochemistry, biological activities, and therapeutic applications of Alpinia oxyphylla Miquel: A review

Zhang, Qiao; Zheng, Yang; Hu, Xiurong; Hu, Xiaolong; Lv, Wen; Lv, Duo; Chen, Jinjin; Wu, Minglan; Song, Qisheng; Shentu, Jianzhong

doi:10.1016/j.jep.2018.05.002

Cited by 82 publications

(62 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Alpinia oxyphylla (A. oxyphylla), the dried ripe fruit of Alpinia oxyphylla Miq., has been long been thought to be "multivalent" for commonly treating diarrhea [25], enuresis (i.e., involuntary urination), dementia [26][27][28], inflammation [29], cancer [29], and other disorders [30,31]. Notably, terpene, the main component of A. oxyphylla, is regarded as a representative constituent with putative pharmacological activities by phytochemical studies.…”

Section: Introductionmentioning

confidence: 99%

Pharmacological Mechanisms Underlying the Neuroprotective Effects of Alpinia oxyphylla Miq. on Alzheimer’s Disease

Wang

Guo

et al. 2020

IJMS

View full text Add to dashboard Cite

Alpinia oxyphylla Miq. (i.e., A. oxyphylla), a traditional Chinese medicine, can exert neuroprotective effects in ameliorating mild cognitive impairment and improving the pathological hallmarks of Alzheimer's disease (AD). Here, 50 active compounds and 164 putative targets were collected and identified with 251 clinically tested AD-associated target proteins using network pharmacology approaches. Based on the Gene Ontology/Kyoto Encyclopedia of Genes and Genomes pathway enrichments, the compound-target-pathway-disease/protein-protein interaction network constructions, and the network topological analysis, we concluded that A. oxyphylla may have neuroprotective effects by regulating neurotransmitter function, as well as brain plasticity in neuronal networks. Moreover, closely-related AD proteins, including the amyloid-beta precursor protein, the estrogen receptor 1, acetylcholinesterase, and nitric oxide synthase 2, were selected as the bottleneck nodes of network for further verification by molecular docking. Our analytical results demonstrated that terpene, as the main compound of A. oxyphylla extract, exerts neuroprotective effects, providing new insights into the development of a natural therapy for the prevention and treatment of AD.

show abstract

Section: Introductionmentioning

confidence: 99%

Pharmacological Mechanisms Underlying the Neuroprotective Effects of Alpinia oxyphylla Miq. on Alzheimer’s Disease

Wang

Guo

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

“…*p < 0.05, **p < 0.01, ***p < 0.001 generation immunotherapeutic vaccine [24]. A. oxyphylla possesses a wide range of biological activities, including anti-diabetes, anti-liver fibrosis, antidiarrheal, and neuronal protection effects [1]. Moreover, several publications have reported anticancer effects of A. oxyphylla such as in liver cancer cells via AKT pathway suppression [5].…”

Section: Discussionmentioning

confidence: 99%

“…Alpinia oxyphylla belongs to the Zingiberaceae family and is widely cultivated in Asia as one of the most frequently used plant extracts in oriental medicine. The most well-known medicinal effect of A. oxyphylla includes enhancing the internal and astringent activities of the kidney and spleen [1]. Recent studies have shown that A. oxyphylla possesses a wide range of pharmacological activities, such as anti-diabetes [2], anti-fibrosis [3], anti-diarrheal [4], and anti-cancer [5].…”

Section: Introductionmentioning

confidence: 99%

Anti-proliferative activity of A. Oxyphylla and its bioactive constituent nootkatone in colorectal cancer cells

et al. 2020

View full text Add to dashboard Cite

Background A. oxyphylla extract is known to possess a wide range of pharmacological activites. However, the molecular mechanism of A. oxyphylla and its bioactive compound nootkatone in colorectal cancer is unknown. Methods Our study aims to examine the role of A. oxyphylla and its bioactive compound nootkatone, in tumor suppression using several in vitro assays. Results Both A. oxyphylla extract and nootkatone exhibited antiproliferative activity in colorectal cancer cells. A. oxyphylla displayed antioxidant activity in colorectal cancer cells, likely mediated via induction of HO-1. Furthermore, expression of pro-apoptotic protein NAG-1 and cell proliferative protein cyclin D1 were increased and decreased respectively in the presence of A. oxyphylla. When examined for anticancer activity, nootkatone treatment resulted in the reduction of colony and spheroid formation. Correspondingly, nootkatone also led to increased NAG-1 expression and decreased cyclin D1 expression. The mechanism by which nootkatone suppresses cyclin D1 involves protein level regulation, whereas nootkatone increases NAG-1 expression at the transcriptional level. In addition to having PPARγ binding activity, nootkatone also increases EGR-1 expression which ultimately results in enhanced NAG-1 promoter activity. Conclusion In summary, our findings suggest that nootkatone is an anti-tumorigenic compound harboring antiproliferative and pro-apoptotic activity.

show abstract

“…Alpinia Fructus Alpiniae Oxyphyllae (dried, ripe seed of Alpiniaoxyphylla Miq) extract has a protective effect on neuronal injury induced by 6-OHDA by anti-inflammatory (gene expression Down streaming of IL-1 and TNF-) and anti-oxidant action (in PC12 cells by NO production inhibition and iNOS expression) 32 . Proto-catechuic acid, a component of Fructus Alpiniae Oxyphyllae, protects C57BL/6J mice from MPTP-induced dopaminergic neuronal damage 33 .…”

Section: Alpiniamentioning

confidence: 99%

Herbal drugs Used on Parkinson Disease

Nagrik¹,

Patil²,

Nagrik

et al. 2020

J. Drug Delivery Ther.

View full text Add to dashboard Cite

Parkinson's disease (PD) is the world's most widespread chronic neuron degenerative motion condition affecting more than 10 million people. The characteristic hallmark of PD involves a progressive loss of doperminergic neuron in the brain's Subetantia Nigra. Considerable Beware of this paid recently to the Bio-friendly Usage plant-based products for neuron prevention, cure and treatment Disease and is degenerative. The herbal drugs therefore are safer than other drugs. Herbal medicine has its roots in ancient civilizations. It includes the usage of medicinal plants to cure disease and enhance general wellbeing. Keywords: Parkinson, Herbal Drug Treatment, Ayurveda

show abstract

Ethnopharmacological uses, phytochemistry, biological activities, and therapeutic applications of Alpinia oxyphylla Miquel: A review

Cited by 82 publications

References 78 publications

Pharmacological Mechanisms Underlying the Neuroprotective Effects of Alpinia oxyphylla Miq. on Alzheimer’s Disease

Pharmacological Mechanisms Underlying the Neuroprotective Effects of Alpinia oxyphylla Miq. on Alzheimer’s Disease

Anti-proliferative activity of A. Oxyphylla and its bioactive constituent nootkatone in colorectal cancer cells

Herbal drugs Used on Parkinson Disease

Contact Info

Product

Resources

About