Ethnopharmacological, Phytochemical and Pharmacological review of Plant <i>Cissus quadrangularis L.</i>

Tiwari, Mamta; Gupta, Pushpraj S; Sharma, Nisha

doi:10.5958/0975-4385.2018.00014.6

Cited by 7 publications

(4 citation statements)

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“…The phytochemical studies showed the presence of various secondary metabolites. The presence of alkaloids, phenol, saponins steroids may be contributed for antioxidant and antidiabetic potential 20,21 .…”

Section: α-Amylase Activitymentioning

confidence: 99%

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2022

IJPSR

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Section: α-Amylase Activitymentioning

confidence: 99%

Untitled

2022

IJPSR

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“…Plant extracts that showed inhibitory activity greater than 5% were considered as active, and plant extracts which showed activity less than 5% against ACE were considered as inactive. Alpina galangal and Cissus quadrangularis are traditionally used for cardiovascular diseases [18,19]. Ziziphus vulgaris was also previously reported as an ACE inhibitor [20].…”

Section: Ace Inhibitory Activity Of Medicinal Plants and Purified Com...mentioning

confidence: 99%

A UPLC-DAD-Based Bio-Screening Assay for the Evaluation of the Angiotensin Converting Enzyme Inhibitory Potential of Plant Extracts and Compounds: Pyrroquinazoline Alkaloids from Adhatoda vasica as a Case Study

et al. 2021

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Angiotensin converting enzyme (ACE) plays a crucial role in regulating blood pressure in the human body. Identification of potential ACE inhibitors from medicinal plants supported the idea of repurposing these medicinal plants against hypertension. A method based on ultra-performance liquid chromatography (UPLC) coupled with a diode array detector (DAD) was used for the rapid screening of plant extracts and purified compounds to determine their ACE inhibitory activity. Hippuryl-histidiyl-leucine (HHL) was used as a substrate, which is converted into hippuric acid (HA) by the action of ACE. A calibration curve of the substrate HHL was developed with the linear regression 0.999. The limits of detection and quantification of this method were found to be 0.134 and 0.4061 mM, respectively. Different parameters of ACE inhibitory assay were optimized, including concentration, incubation time and temperature. The ACE inhibition potential of Adhatoda vasica (methanolic-aqueous extract) and its isolated pyrroquinazoline alkaloids, vasicinol (1), vasicine (2) and vasicinone (3) was evaluated. Compounds 1–3 were characterized by various spectroscopic techniques. The IC50 values of vasicinol (1), vasicine (2) and vasicinone (3) were found to be 6.45, 2.60 and 13.49 mM, respectively. Molecular docking studies of compounds 1–3 were also performed. Among these compounds, vasicinol (1) binds as effectively as captopril, a standard drug of ACE inhibition.

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“…Several investigations have reported the therapeutic uses of the plant Cissus quadrangularis (CQ), commonly known as 'Hadjod' in the Indian Ayurvedic system. This plant is renowned for its fracture healing properties, antibacterial action, antioxidative effects, antiulcer treatment, antiosteoporotic benefits, cholinergic activity, gastroprotective action, and positive effects on cardiovascular activities [21]. Phytochemical analysis of methanolic extract has reported the presence of triterpenes such as αand βamyrins, ketosteroids, βsitosterol, carotene, tannins, phenols, and vitamin C. Every part of this plant has been utilized in pharmacological actions, and is studied in the form of crude powdered extract for its effectiveness in therapies with a plant origin [22].…”

Section: Introductionmentioning

confidence: 99%

Establishing the Callus-Based Isolation of Extracellular Vesicles from Cissus quadrangularis and Elucidating Their Role in Osteogenic Differentiation

Gupta,

Gupta

et al. 2023

JFB

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Extracellular vesicles (EVs) are nano-sized vehicles secreted by all live cells to establish communication with adjacent cells. In recent years, mammalian EVs (MEVs) have been widely investigated for their therapeutic implications in human disease conditions. As the understanding of MEV composition and nature is advancing, scientists are constantly exploring alternatives for EV production with similar therapeutic potential. Plant-derived exosome-like nanovesicles (PDEVs) may be a better substitute for MEVs because of their widespread sources, cost-effectiveness, and ease of access. Cissus quadrangularis (CQ), known as “bone setter or Hadjod”, is a perennial plant utilized for its osteogenic potential. Its crude powder extract formulations are widely used as tablets and syrups. The present work elucidates the isolation of exosome-like nanovesicles (henceforth exosomes) from the culture supernatants of an in vitro cultured callus tissue derived from CQ. The physical and biological properties of the exosomes were successfully investigated using different characterization techniques. The therapeutic potential of the CQ exosomes was found to ameliorate the wound scratch injury and oxidative stress conditions in human-derived mesenchymal stem cells (hMSCs) and the pre-osteoblast (MC3T3) cell line. These exosomes also induced the proliferation and differentiation of hMSCs, as observed by alkaline phosphatase activity. These findings may serve as a proof of concept for further investigating the CQ exosomes as a nanocarrier for drug molecules in various therapeutic bone applications.

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Ethnopharmacological, Phytochemical and Pharmacological review of Plant Cissus quadrangularis L.

Cited by 7 publications

References 0 publications

Untitled

Untitled

A UPLC-DAD-Based Bio-Screening Assay for the Evaluation of the Angiotensin Converting Enzyme Inhibitory Potential of Plant Extracts and Compounds: Pyrroquinazoline Alkaloids from Adhatoda vasica as a Case Study

Establishing the Callus-Based Isolation of Extracellular Vesicles from Cissus quadrangularis and Elucidating Their Role in Osteogenic Differentiation

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