Ethnopharmacological investigation of the diuretic and hemodynamic properties of native species of the Brazilian biodiversity

Abstract

The results presented here shown that the ES-EG obtained from E. grandiflorus leaves shown a significant diuretic and hypotensive activity and suggest that these effects could be related with an important renal and systemic vasodilator effect. In addition, it was shown for the first time that the pharmacological effects of ES obtained from P. tenellus and C. carthagenensis do not support its popular use as a diuretic agent.

Endothelium-Dependent Effects of Echinodorus grandiflorus (Cham. & Schltdl.) Micheli Mediated by M3-Muscarinic and B2-Bradykininergic Receptors on Peripheral Vascular Resistance and Its Modulatory Effects on K+ Channels in Mesenteric Vascular Beds

“…Echinodorus grandiflorus is an important medicinal species known for its diuretic and antihypertensive effects [5, 6, 8]. Although some preclinical studies have shown the effectiveness of various preparations obtained from E. grandiflorus in different animal models, the effects on peripheral vascular resistance remain unknown.…”

“…Several preclinical pharmacological studies have presented E. grandiflorus as a promising species for the treatment of cardiovascular diseases. Available data have shown that different preparations obtained from the species could present diuretic [5, 6], antiedematous [7], antihypertensive [6–8], and vasodilatory effects [9].…”

“…Many diterpenoids, alkaloids, saponins, and tannins have been identified [1, 7]. Moreover, phenolic compounds, mainly flavonoids C-glycosides including isoorientin, isoorientin-O-rhamnoside, isoorientin-O-rhamnoside-dimethylether, isoorientin 7,3′-dimethylether, swertiajaponin, swertiajaponin-O-rhamnoside, isovitexin, isovitexin-O-rhamnoside, swertisin, and swertisin-O-rhamnoside, have been recently described [5, 6].…”

Heart-Protective Effects of Echinodorus grandiflorus in Rabbits That Are Fed a High-cholesterol Diet

“…The presence of different classes of secondary metabolites, including alkaloids, tannins, terpenoids, and saponins, has drawn attention [15,18]. However, polyphenolic compounds, including tannins, flavonoids, and C-glycosides, are worth mentioning because of their diuretic and antihypertensive effects [19,20]. Recent pharmacological studies have shown that different preparations that are obtained from E. grandiflorus have diuretic [19,20], antiedematous [18], anti-inflammatory [21,22], antihypertensive [20,23], and vasodilatory [24] effects, making the species a potential new candidate for herbal medicines.…”

Mecanismos de atividade antiúlcera de <i>Phyllanthus tenellus</i> Roxb. (Phyllanthaceae) e isolamento dos principais constituintes

“…Os resultados foram expressos em porcentagem de área relativa de lesão.As plantas medicinais têm sido uma valiosa fonte de novas moléculas, sendo consideradas alternativas na busca de novos medicamentos(ZAKARIA et al, 2011). Há uma rica variedade de plantas medicinais que são utilizadas como gastroprotetoras naPrando et al (2015) detectaram a presença de vários taninos hidrolisáveis e flavonoides, tal como a quercetina, na fração aquosa das partes aéreas de P. tenellus. Os taninos hidrolisáveis foi observada em extrato aquoso e está em conformidade com Sprenger e Cass (2013).…”