Ethnomedicinal, phytochemical and pharmacological updates on Hygrophila auriculata (Schum.) Hiene: an overview

Sethiya, Neeraj Kumar; Ahmed, N; Shekh, Raeesh M.; Kumar, Vivek; Singh, Pawan; Kumar, Vipin

doi:10.1016/j.joim.2018.07.002

Cited by 28 publications

(12 citation statements)

References 54 publications

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“…The seeds from the Acanthaceae family were characterised by their high content in oil (up to 30%). Phytochemical investigations of H. auriculata (Acanthaceae family) reported major classes of fatty acids and essential oils (Sethiya et al ., 2018). The starch content ranged between 53 g/100 g (Acanthaceae) and 75.5 g/100 g (Onagraceae).…”

Section: Resultsmentioning

confidence: 99%

Plant seeds as source of nutrients and phytochemicals for the Indian population

Cervera‐Mata

Sahu

Chakradhari

et al. 2021

Int J of Food Sci Tech

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Plant seeds are major sources of nutrients and bioactive compounds for human beings and vary across different locations. In addition, they are under used foods that could be a good complement for the daily nutrition of people. Therefore, the aim of this study was the analysis of different physical parameters, nutrients and bioactive compounds of 60 plant seeds belonging to 48 species and 9 families. The seeds were collected in 2016-2017 in the Raipur area, India (21.25°N 81.63°E), from three different locations. Fat, protein, starch, total polyphenols and mineral contents ranged from 0.7 to 44.2, 1.6 to 68.5, 11.3 to 84.0, 0.01 to 3.85 and 0.67 to 4.91 g/100 g (dry weight) respectively. Regarding physical properties, the heavier seeds were covered with thick testa over the range of 3.0 to 40% of the seed mass. Higher moisture and ash fractions for the starchy (cereal and pulses) and weed seeds were also found. The most abundant mineral elements in the seeds were P, S, K, Mg, Ca, Fe and Zn. Finally, it was calculated the contribution of the consumption of seeds to the daily macronutrients and micronutrients intake for Indian population, reaching up to 38, 13 and 25% for proteins, fat and carbohydrates respectively.

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Section: Resultsmentioning

confidence: 99%

Plant seeds as source of nutrients and phytochemicals for the Indian population

Cervera‐Mata

Sahu

Chakradhari

et al. 2021

Int J of Food Sci Tech

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“…We have created a library of 586 bioactive phytochemicals having antiviral properties from 47 medicinal plants from the literature ( Supplementary Table 1 ). 21 , 23 , 24 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 The 3D.sdf structures of all the selected phytochemicals were obtained from the PubChem database ( https://pubchem.ncbi.nlm.nih.gov/ ).…”

Section: Methodsmentioning

confidence: 99%

The dual role of phytochemicals on SARS-CoV-2 inhibition by targeting host and viral proteins

Singh

Chauhan

Pandit

et al. 2022

Journal of Traditional and Complementary Medicine

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Background The severe acute respiratory syndrome-2019 has affected more than 190 million people around the world and caused severe crises throughout the globe. Due to rapid mutation in the viral genome, it became important to simultaneously improvise the host immunity while targeting the viral protein to reduce the severity of the infection. Aim The current computational work focuses on multi-level rigorous screening of 47 medicinal plant-based phytochemicals for discovering effective phytochemical inhibitors against the host and viral targets. Experimental procedure A total of 586 phytochemicals were analyzed in detail based on their drug-likeness, pharmacological properties, and structure-based activity against the viral proteins (Spike glycoprotein, Papain-like protease, and Main protease) and host proteins (ACE2, Importin-subunit α-5, and β-1). Phytochemicals showing higher binding affinity with the dual capacity to target both the categories of proteins were further analyzed by profiling their chemical reactivity using Density-functional theory (DFT) based quantum chemical methods. Finally, detailed molecular dynamics simulations were performed to analyze the interactions of the complexes. Results and conclusion The results revealed that the selected phytochemicals from Andrographis paniculata , Aconitum heterophyllum , Costus speciosus and Inula racemosa may have the capacity to act with prominent affinity towards the host and viral proteins. Therefore, The Combination of active phytochemicals of these plants may prove to be more beneficial and can be used for developing the potential phytotherapeutic intervention.

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“…39 These triterpenoids and sterols were reported to possess anti-nociceptive and antiinflammatory activities. [39][40][41] Specifically, stigmasterol and lupeol were reported to demonstrate significant antinociceptive and anti-inflammatory properties. [42][43][44][45] Similarly, lup-20(29)-ene-3β,23-diol was reported to exhibit anti-inflammatory activity.…”

Section: Discussionmentioning

confidence: 99%

“…38 Various sterols and triterpenoids were also reported from similar species such as H. spinosa and H. auriculate . 39 These triterpenoids and sterols were reported to possess anti-nociceptive and anti-inflammatory activities. 39 – 41 Specifically, stigmasterol and lupeol were reported to demonstrate significant anti-nociceptive and anti-inflammatory properties.…”

Section: Discussionmentioning

confidence: 99%

<p>Anti-Nociceptive and Anti-Inflammatory Activity of <em>Hygrophila schulli</em> Leaves</p>

Tekulu¹,

Desta²,

Hiben³

et al. 2020

JIR

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The management of pain and inflammation with non-steroidal anti-inflammatory drugs and opioid analgesics are currently encountering severe adverse reactions. To overcome these problems, herbal remedies may offer new alternative medicines. Hygrophila schulli is a medicinal plant traditionally used for the treatment of pain and inflammationrelated disorders; yet, these claims are not scientifically validated. Hence, this study was aimed to validate the traditional use of Hygrophila schulli leaves as anti-inflammatory and analgesic remedy. Methods: In vitro anti-hyaluronidase assay and in vivo carrageenan-induced hind paw oedema model were used to evaluate the anti-inflammatory property of ethanolic leaf extract of Hygrophila schulli. Tail immersion and acetic acid-induced writhing tests were performed to determine the central and peripheral analgesic activity of the leaf extract, respectively. Results: The ethanolic leaf extract exhibited significant anti-hyaluronidase activity (P<0.001) and significant inhibition of carrageenan-induced paw oedema (P<0.05) compared to untreated controls. Similarly, the extract significantly prolonged the reaction time of mice (P<0.05) for the hot-water stimuli. Furthermore, an oral dose of the extract showed significant inhibition (P<0.01) of acetic acid-induced abdominal contractions of mice. Besides, the ethanolic leaf extract did not cause any obvious sign of acute toxicity at a single oral dose of 2 g/kg. Conclusion: The findings of this study may partially support the acclaimed traditional use of Hygrophila schulli leaves for the treatment of pain and inflammatory conditions.

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Ethnomedicinal, phytochemical and pharmacological updates on Hygrophila auriculata (Schum.) Hiene: an overview

Cited by 28 publications

References 54 publications

Plant seeds as source of nutrients and phytochemicals for the Indian population

Plant seeds as source of nutrients and phytochemicals for the Indian population

The dual role of phytochemicals on SARS-CoV-2 inhibition by targeting host and viral proteins

<p>Anti-Nociceptive and Anti-Inflammatory Activity of <em>Hygrophila schulli</em> Leaves</p>

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