Ethnomedicinal and therapeutic values of Flacourtia jangomas

A, Rai.; Mishra, Tulika

doi:10.5958/2455-7218.2020.00037.6

Cited by 5 publications

(3 citation statements)

References 11 publications

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“…Mishra and Rai [9] also reported that they have xanthones, quinones, limonoids and phenazines, and two limonoids, namely limolin and jangomolide in the stem and bark of F. Jangomas. Rai and Mishra [5] also described in their review article that the fruit and stem bark yielded a coumarin named ostruthin. The phenolic glucoside ester, flacourtin was reported in bark whereas, a butyrolactone lignan disaccharide named ramontoside and steroids including β-sitosterol and its β-D-glucopyranoside were reported in the heartwood [10].…”

Section: Phytochemistrymentioning

confidence: 99%

“…The Wealth of India [4] also communicated that the common names of Flacourtia jangomas are Coffee plum, Indian plum, Manila cherry, and Paniala and it is widely cultivated in Southeast and East Asia and has escaped cultivation in a number of places. Aerial parts of the plant are used in the handling of diabetics, asthma, anemia, and antibacterial, antidiarrheal, and antioxidant activities [5]. Das et al [6] updated that F. jangomas revealed several bioactive constituents, including carbohydrates, protein, lipids, alkaloids, glycosides, tannins, etc.…”

Section: Introductionmentioning

confidence: 99%

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Ethnomedicinal Potential of Indian Coffee Plum: Flacourtia Jangomas

Kumar Srivastava,

Singh,

Singh

2023

ABR

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Medicinal plants are large-scale sources of indigenous medicines and they have been used for centuries to treat various diseases. Bioactive compounds are being isolated from medicinal plants day by day and serve as an important source of raw materials for drug discovery. Flacourtia jangomas is a plant belonging to the family of Flacourtiaceae growing in various parts of the world. Common names of F. jangomas are Coffee plum, Indian plum, Manila cherry, and Paniala. Aerial parts of the plant are used in the treatment of diabetics, asthma, anemia, and antibacterial, antidiarrheal, and antioxidant activities. F. jangomas revealed several bioactive constituents, including carbohydrates, protein, lipids, alkaloids, glycosides, tannins, etc. The fruits are rich in nutrients, protein, fat, sugars, amino acids, vitamin C, and minerals including calcium, potassium, phosphorous, iron, magnesium, sodium, manganese, copper, and zinc. The ripe fruits have high fiber content together with good protein content, low fat, and higher amount of monounsaturated fatty acids as compared to polyunsaturated fatty acids. It contains a significant amount of beta-carotene followed by lutein and zeaxanthin, retinol, and phylloquinone which are important in the regulation of hemoglobin and fibrinogen in the human body. Flacourtiaceae family elaborates a diverse array of compound classes which include terpenoids, alkaloids, flavonoids and tannins, lignans and flavanolignans, glucosides, coumarins, and isocoumarins.

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Section: Phytochemistrymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ethnomedicinal Potential of Indian Coffee Plum: Flacourtia Jangomas

Kumar Srivastava,

Singh,

Singh

2023

ABR

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“…Existing literature clearly indicates that F. jangomas exhibits a broad array of pharmacological activities, as evidenced by its diverse range of chemical constituents. Both phytochemical and pharmacological studies have revealed that extracts from different parts and the main active components of F. jangomas demonstrate antimicrobial, antidiabetic, antidiarrheal, and antioxidant properties [20,21]. Moreover, a recent study noted the hepatoprotective activity of F. jangomas in the Paracetamol-induced HepG2 cell line [22].Hence, the objective of this research is to identify a highly selective compound that targets both the androgen receptor and/oracetyl cholinesterase, with the potential to serve as a therapeutic agent for the treatment of liver-related diseases.…”

Section: Introductionmentioning

confidence: 99%

In Silico Evaluation Of Flacourtia Jangomas Compounds For Hepatoprotective Activity: A Molecular Docking Study

Barbhuiya,

Choudhury,

Laskar

et al. 2024

jaz

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The liver is prone to damage induced by xenobiotics, which significantly contributes to the widespread prevalence of liver diseases. To explore potential therapeutic avenues, this in silico study utilizes molecular docking techniques to elucidate interactions between bioactive compounds derived from Flacourtia jangomas and their target proteins, particularly the androgen receptor (AR) and acetyl cholinesterase, both implicated in hepatocellular carcinogenesis. While pharmaceutical drugs for liver diseases exist, their limitations necessitate the exploration of alternative options. Plant-derived compounds have garnered attention for their potential beneficial effects, with Flacourtia jangomas emerging as a promising candidate due to its known pharmacological activities. Through our investigation, we identified several compounds, including catechin, limonin, jangomolide, rutin hydrate, hydnocarpic acid, and chaulmoogric acid, which exhibited notable interactions with AR and acetyl cholinesterase. Enzalutamide, an AR inhibitor, demonstrated a docking score lower than catechin but higher than other compounds, indicating its potential therapeutic efficacy. Catechin exhibited the highest binding affinity, supported by more favorable scores, signifying strong interactions with AR. Rutin hydrate displayed superior docking parameters against acetyl cholinesterase compared to neostigmine. Considering various scoring parameters such as lipo, ambig, clash, and rot scores, catechin and rutin hydrate emerged as favorable options over enzalutamide and neostigmine, respectively. However, experimental validation is essential to confirm these findings. The compounds identified in this study hold promise for the development of clinically effective hepatoprotective agents.

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In Silico and In Vitro Investigation of Phytoconstituents from Flacourtia Jangomas as a Potential Candidate for the Treatment of Type 2 Diabetes Mellitus

Tomar,

Mishra,

Sahoo

et al. 2024

ChemistrySelect

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Flacourtia jangomas is a plant used for centuries in Brazil, China, India, and the Malaya Peninsula to treat conditions such as diabetes, asthma, anaemia, and diarrhoea. Despite its therapeutic and economic benefits, the plant has not been popular among farmers due to its limited yield and lack of knowledge about its potential. Targeting PPARγ agonists is a promising approach for discovering and developing effective drugs to treat type 2 diabetes. Due to the activation of the PPARγ through PPARγ agonists, target genes implicated in inflammation, adipogenesis, lipid metabolism, and glucose metabolism are transcriptionally regulated. This study analysed the curated datasets of F. jangomas to identify the binding conformations of the phytoconstituents with different T2DM targets through molecular docking, molecular dynamics, and ADMET prediction approach. To determine the most favourable binding conformations of phytoconstituents that bind with the PPARγ receptors, density functional theory and principal component analysis were performed. The study reveals that the phytoconstituents of F. jangomas can act as PPARγ agonists and could be used to design and optimise the potential antidiabetic agents inspired by natural products. These findings provide a promising approach towards developing effective antidiabetic drugs.

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Ethnomedicinal and therapeutic values of Flacourtia jangomas

Cited by 5 publications

References 11 publications

Ethnomedicinal Potential of Indian Coffee Plum: Flacourtia Jangomas

Ethnomedicinal Potential of Indian Coffee Plum: Flacourtia Jangomas

In Silico Evaluation Of Flacourtia Jangomas Compounds For Hepatoprotective Activity: A Molecular Docking Study

In Silico and In Vitro Investigation of Phytoconstituents from Flacourtia Jangomas as a Potential Candidate for the Treatment of Type 2 Diabetes Mellitus

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