Ethnobotany, Phytochemistry, Traditional and Modern Uses of Actaea racemosa L. (Black cohosh): A Review

Salari, S H; Amiri, Mohammad Sadegh; Ramezani, Mohammad; Moghadam, Ali Tafazoli; Elyasi, Sepideh; Sahebkar, Amirhossein; Emami, Seyed Ahmad

doi:10.1007/978-3-030-64872-5_24

Cited by 8 publications

(10 citation statements)

References 118 publications

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“…Mostly, the bioactivity assays aim at evaluating the effects of triterpenoids for Actaea extracts or sesquiterpenes for Petasites extracts. For the genus Cimicifuga/Actaea this has been recently reviewed by Guo et al (2017) and Salari et al (2021). A review concerning the use of Petasites species as medicinal plants has been published by Aydin et al (2013).…”

Section: Biological Activities Of Fukinolic Acid and Cimicifugic Acidsmentioning

confidence: 99%

“…In the European Pharmacopoeia, an extract from rhizomes of A. racemosa is recommended as ''Herbal medicinal product for the relief of menopausal complaints such as hot flushes and profuse sweating'' (EMA/HMPC/48745/ 2017). The pharmacological properties of Actaea racemosa have very recently been compiled by Salari et al (2021). The pharmaceutically most recognized compounds of Actaea species are triterpene glycosides with a cycloartane skeleton such as actein (acetylacteol-3-O-D-xyloside).…”

Section: Introductionmentioning

confidence: 99%

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Fukinolic acid and cimicifugic acids: a review

Jahn

Petersen

2021

Phytochem Rev

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During the last decades, the research on the biological activities of extracts from Cimicifuga/Actaea species and Petasites japonicus as well as their active ingredients has been intensified. Besides terpenoids as dominant natural product group, hydroxycinnamic acid esters such as fukinolic acid and several cimicifugic acids have been isolated from Actaea and Petasites species and their chemical structures have been elucidated. Investigations on the biological properties of these hydroxycinnamic acid esters are currently undertaken and some compounds might be promising therapeutic tools. In this review, we have gathered information on the genera Actaea and Petasites, the occurrence of cimicifugic and fukinolic acids and some aspects of their biosynthesis. Furthermore, we have summarized the medicinal aspects of fukinolic acid and cimicifugic acids. In connection with the biological activities of these compounds, structural features of the hydroxycinnamic acid derivatives move into the focus. The position of the hydroxyl group at the aromatic rings and the introduction of an electron-donating moiety may be important for anti-inflammatory, antiviral, cytotoxic and vasoactive effects of these compounds.

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Section: Biological Activities Of Fukinolic Acid and Cimicifugic Acidsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fukinolic acid and cimicifugic acids: a review

Jahn

Petersen

2021

Phytochem Rev

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“…BC was exported to Europe as early as the 18th century and used by Europeans to treat menopausal symptoms and other difficulties related to the female reproductive system [9,10]. Currently, BC is widely used to alleviate menopausal symptoms such as hot flashes, night sweats, sleep disturbances, vertigo, nervousness, mood swings, and vaginal dryness [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

“…The first medicinal formulation of BC-an isopropanolic extract standardized to triterpene glycosides (Remifemin ® )-has been available since 1956 [9]. Up to today, approximately 40 clinical trials, including different BC extracts and formulations, have been conducted [11,12]. Several trials showed no impact of BC on alleviating menopausal symptoms, but most of them revealed the potential of BC as the alternative for hormone replacement therapy in menopausal women with very few adverse side effects [9,11,12,14,15].…”

Section: Introductionmentioning

confidence: 99%

In Vitro and In Vivo Imaging-Based Evaluation of Doxorubicin Anticancer Treatment in Combination with the Herbal Medicine Black Cohosh

Płoska,

Wozniak,

Hedhli

et al. 2023

IJMS

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As a substitution for hormone replacement therapy, many breast cancer patients use black cohosh (BC) extracts in combination with doxorubicin (DOX)-based chemotherapy. In this study, we evaluated the viability and survival of BC- and DOX-treated MCF-7 cells. A preclinical model of MCF-7 xenografts was used to determine the influence of BC and DOX administration on tumor growth and metabolism. The number of apoptotic cells after incubation with both DOX and BC was significantly increased (~100%) compared to the control. Treatment with DOX altered the potential of MCF-7 cells to form colonies; however, coincubation with BC did not affect this process. In vivo, PET-CT imaging showed that combined treatment of DOX and BC induced a significant reduction in both metabolic activity (29%) and angiogenesis (32%). Both DOX and BC treatments inhibited tumor growth by 20% and 12%, respectively, and combined by 57%, vs. control. We successfully demonstrated that BC increases cytotoxic effects of DOX, resulting in a significant reduction in tumor size. Further studies regarding drug transport and tumor growth biomarkers are necessary to establish the underlying mechanism and potential clinical use of BC in breast cancer patients.

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“…Cimicifuga (or Actaearacemosa, or black cohosh) is a popular herbal medication derived from North America, which is claimed to have estrogen-like and anti-inflammatory effects (Salari et al, 2021).…”

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confidence: 99%