Ethnobotany, Phytochemistry, Pharmacology of the Korean Campanulaceae: A Comprehensive Review

Kim, Hyun-Jun; Kang, Shin-Ho

doi:10.7732/kjpr.2017.30.2.240

Cited by 3 publications

(4 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…By repetitive chromatographic separation of the hot water extract, three new neolignan glucosides (1)(2)(3) were isolated, along with 15 known compounds, including five lignans (4)(5)(6)(7)(8), five phenolic compounds (9-13), and five flavonoids (14)(15)(16)(17)(18), in the present research (Figure 1). It was reported that the n-butanol and ethyl acetate fractions of C. takesimana exhibit free radical-scavenging, tyrosinase inhibition, and superoxide dismutase (SOD)-like activities [2].…”

Section: Structure Elucidation Of New Compounds 1-3mentioning

confidence: 60%

“…It was reported that the n -butanol and ethyl acetate fractions of C. takesimana exhibit free radical-scavenging, tyrosinase inhibition, and superoxide dismutase (SOD)-like activities [ 2 ]. Although extensive research has been done on the pharmacological activities and/or phytochemical constituents of the plants belonging to family Campanulaceae, yet only few studies have been conducted on the genus Campanula , despite their frequent traditional use [ 3 ]. Moreover, chemical constituents of C. takesimana have never been reported from previous studies.…”

Section: Introductionmentioning

confidence: 99%

“…Thereafter, the isolates were assessed for their inhibitory effects on the production of the pro-inflammatory mediator, PGE 2 , in LPS-stimulated RAW264.7 macrophages. We describe in this paper the isolation of the secondary metabolites from the leaves of P. japonicus, structure elucidation of the three new neolignan glucosides (1)(2)(3), and inhibitory effects of the isolates on PGE 2 production.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Chemical Constituents of the Leaves of Campanula takesimana (Korean Bellflower) and Their Inhibitory Effects on LPS-induced PGE2 Production

Choi

Son

et al. 2020

Plants

View full text Add to dashboard Cite

Campanula takesimana Nakai (Campanulaceae; Korean bellflower) is one of the endemic herbs of Korea. The plant has been used as traditional medicines for treating asthma, tonsillitis, and sore throat in Korea. A hot water extract of the leaves of C. takesimana exhibited a significant inhibitory effect on lipopolysaccharide (LPS)-stimulated prostaglandin E2 (PGE2) production. Repetitive chromatographic separation of the hot water extract led to the isolation of three new neolignan glucosides, campanulalignans A–C (1–3), with 15 known compounds (4–18). The structures of new compounds 1–3 were elucidated by analyzing nuclear magnetic resonance (NMR) spectroscopic data, along with high resolution quadrupole time of flight mass (HR-Q-TOF-MS) spectrometric data. Among the isolates, simplidin (7), 5-hydroxyconiferaldehyde (11), icariside F2 (12), benzyl-α-l-arabinopyranosyl-(1″→6′)-β-d-glucopyranoside (13), and kaempferol 3-O-β-d-apiosyl (1→2)-β-d-glucopyranoside (15) were isolated from the Campanulaceae family for the first time. The isolates (1, 2, and 4–18) were assessed for their anti-inflammatory effects on LPS-stimulated PGE2 production on RAW 264.7 cells. 7R,8S-Dihydrodehydrodiconiferyl alcohol (5), 3′,4-O-dimethylcedrusin 9-O-β-glucopyranoside (6), pinoresinol di-O-β-d-glucoside (8), ferulic acid (10), 5-hydroxyconiferaldehyde (11), and quercetin (18) showed significant inhibitory effects on LPS-stimulated PGE2 production.

show abstract

Section: Structure Elucidation Of New Compounds 1-3mentioning

confidence: 60%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Chemical Constituents of the Leaves of Campanula takesimana (Korean Bellflower) and Their Inhibitory Effects on LPS-induced PGE2 Production

Choi

Son

et al. 2020

Plants

View full text Add to dashboard Cite

show abstract

“…Compared with the results from previous studies [ 2 , 8 , 16 , 31 , 32 ], 56 chemical components were identified for the first time in Campanulaceae. The stem, leaf and seed contain more flavonoids but few saponins that can be easily discriminated from the root.…”

Section: Discussionmentioning

confidence: 49%

Nontargeted Metabolomic Analysis of Four Different Parts of Platycodon grandiflorum Grown in Northeast China

et al. 2017

View full text Add to dashboard Cite

Platycodonis radix is extensively used for treating cough, excessive phlegm, sore throat, bronchitis and asthma in the clinic. Meanwhile, the stems, leaves and seeds of Platycodon grandiflorum (PG) have some pharmaceutical activities such as anti-inflammation and anti-oxidation effects, etc. These effects must be caused by the different metabolites in various parts of herb. In order to profile the different parts of PG, the ultra-high performance liquid chromatography combined with quadrupole time-of- flight mass spectrometry (UPLC-QTOF-MSE) coupled with UNIFI platform and multivariate statistical analyses was used in this study. Consequently, for the constituent screening, 73, 42, 35, 44 compounds were characterized from the root, stem, leaf and seed, respectively. The stem, leaf and seed contain more flavonoids but few saponins that can be easily discriminated in the root. For the metabolomic analysis, 15, 5, 7, 11 robust biomarkers enabling the differentiation among root, stem, leaf and seed, were discovered. These biomarkers can be used for rapid identification of four different parts of PG grown in northeast China.

show abstract

Adenophorae Radix Reduces Fibrosis in a Bleomycin-Induced Pulmonary Fibrosis Mouse Model

Kim,

Park,

et al. 2024

Natural Product Communications

View full text Add to dashboard Cite

Background: A screening study investigated the effects of lung-moistening herbal medicines on a bleomycin-induced pulmonary fibrosis mouse model and reported that the efficacy of Adenophorae Radix (ADR) was higher than that of other remedies. Objectives: This study aimed to investigate the antifibrotic efficacy and mechanism of action of ADR in a mouse model of bleomycin-induced pulmonary fibrosis. Materials and Methods: ADR water extract was prepared and orally administered at doses of 30, 100, and 300 mg/kg for 10 days after intratracheal bleomycin instillation. Changes in the body weight and lung histology were assessed. In addition, the quantity of inflammatory cells in the bronchoalveolar lavage fluid (BALF) and the level of transforming growth factor-β and α-smooth muscle actin (α-SMA) were measured. Results: ADR treatment decreased the degree of histological fibrosis based on the Ashcroft score and the number of inflammatory cells in BALF. Moreover, α-SMA level in the lung tissue decreased. ADR at 300 mg/kg resulted in the most significant reduction in the measured indicators. Conclusion: The results indicate that the administration of 300 mg/kg ADR attenuates pulmonary fibrosis in an animal model of idiopathic pulmonary fibrosis; thus, ADR can be considered as a candidate treatment for lung fibrosis.

show abstract

Ethnobotany, Phytochemistry, Pharmacology of the Korean Campanulaceae: A Comprehensive Review

Cited by 3 publications

References 42 publications

Chemical Constituents of the Leaves of Campanula takesimana (Korean Bellflower) and Their Inhibitory Effects on LPS-induced PGE2 Production

Chemical Constituents of the Leaves of Campanula takesimana (Korean Bellflower) and Their Inhibitory Effects on LPS-induced PGE2 Production

Nontargeted Metabolomic Analysis of Four Different Parts of Platycodon grandiflorum Grown in Northeast China

Adenophorae Radix Reduces Fibrosis in a Bleomycin-Induced Pulmonary Fibrosis Mouse Model

Contact Info

Product

Resources

About