Ethnobotany, phytochemistry, pharmacology, and toxicology of the genus Sambucus L. (Viburnaceae)

Waswa, Emmanuel Nyongesa; Li, Jing; Mkala, Elijah Mbandi; Wanga, Vincent Okelo; Mutinda, Elizabeth Syowai; Nanjala, Consolata; Odago, Wyclif Ochieng; Katumo, Daniel Mutavi; Gichua, Moses Kirega; Gituru, Robert Wahiti; Hu, Guang‐Wan; Wang, Qingfeng

doi:10.1016/j.jep.2022.115102

Cited by 19 publications

(14 citation statements)

References 101 publications

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“…Some natural compounds have anti-aging potential. Anthocyanins are water-soluble flavonoid pigments extracted from the fruits of Sambucus canadensis , or elderberry, and have anti-inflammatory and antioxidant biological properties [ 10 ]. Owing to the polyphenolic structure of anthocyanin, they can react with metal ions, prevent the catalytic effect of active metal ions, inhibit the generation of free radicals, and produce antioxidant effects [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Anti-Aging Effects of Anthocyanin Extracts of Sambucus canadensis Caused by Targeting Mitochondrial-Induced Oxidative Stress

Yang

Tang

et al. 2023

IJMS

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Anthocyanin is a natural antioxidant agent extracted from the fruits of Sambucus canadensis, which has been considered to have potential anti-aging effects. Cell senescence is the primary cause of aging and related diseases. Recently, research on the development of compounds for eliminating senescent cells or damaged organs have shown prospects. The compounds which promote the clearing of senescent cells are called “senolytics”. Though anthocyanin is considered to have potential anti-aging effects owing to its anti-inflammatory and antioxidant activities, the mechanism of the elimination of senescent cells remains unclear. In this study, we prepared anthocyanins extracted from the fruits of Sambucus canadensis and evaluated their anti-aging effects in vivo and in vitro. We found that anthocyanin could significantly reduce cell senescence and aging of the lens by inhibiting the activity of the PI3K/AKT/mTOR signaling pathway, consequently promoting the apoptosis of senescent cells, increasing the autophagic and mitophagic flux, and enhancing the renewal of mitochondria and the cell to maintain cellular homeostasis, leading to attenuating aging. Therefore, our study provided a basis for anthocyanin to be used as new “senolytics” in anti-aging.

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Section: Introductionmentioning

confidence: 99%

Anti-Aging Effects of Anthocyanin Extracts of Sambucus canadensis Caused by Targeting Mitochondrial-Induced Oxidative Stress

Yang

Tang

et al. 2023

IJMS

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“…According to several studies [ 12 , 13 , 14 , 18 , 58 , 59 , 60 , 61 , 62 , 63 ], elderberry leaves contain a large amount of phenolic compounds (caffeic acid and chlorogenic acid), flavonoids (quercetin-rutinoside), and anthocyanins (cyanidin-glucoside) ( Table 5 ). For example, Kiprovski et al [ 62 ] studied the changes that occurred during ripening in the leaves and fruits of wild and cultivated Sambucus nigra through sonication and analyzed the extracts using HPLC-DAD-ESI-MS.…”

Section: Walnut ( Juglans Regia L) and Elderberry ...mentioning

confidence: 99%

Walnut By-Products and Elderberry Extracts—Sustainable Alternatives for Human and Plant Health

Sandu-Bălan (Tăbăcariu),

Ifrim,

Patriciu

et al. 2024

Molecules

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A current alternative for sustainable development through green chemistry is the replacement of synthetic compounds with natural ones through the superior capitalization of natural resources, with numerous applications in different fields. The benefits of walnuts (Juglans regia L.) and elderberries (Sambucus nigra L.) have been known since ancient times, due to the presence of phytochemicals such as flavonoids, polyphenols, carotenoids, alkaloids, nitrogen-containing compounds, tannins, steroids, anthocyanins, etc. These active compounds have multiple biological activities for human health, including benefits that are antibacterial, antioxidant, anti-inflammatory, antidiabetic, hepatoprotective, antihypertensive, neuroprotective, etc. Like other medicinal plants, the walnut and the elderberry possess important phytosanitary properties (antibacterial, antifungal, and insecticidal) and their extracts can also be used as environmentally safe biopesticides, with the result that they constitute a viable and cheap alternative to environmentally harmful synthetic products. During recent years, walnut by-products and elderberries have attracted the attention of researchers, and investigations have focused on the species’ valuable constituents and active properties. Comparing the information from the literature regarding the phytochemical profile and biological activities, it is highlighted that, apart from the predominant specific compounds, the walnut and the elderberry have common bioactive compounds, which come from six classes (phenols and derivatives, flavonoids, hydroxycinnamic acids, tannins, triterpenoids, and phytosteroids), and act on the same microorganisms. From this perspective, the aim of this review is to provide an overview of the bioactive compounds present in the different constitutive parts of walnut by-products and elderberries, which present a specific or common activity related to human health and the protection of agricultural crops in the context of sustainable development.

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“…The anthocyanins of S. canadensis were reportedly shown to have potential antiaging effects since they exhibited antioxidant and anti-inflammatory properties [ 124 ]. The primary cause of aging and age-related diseases is cell senescence and, consequently, the accumulation of senescent cells in different tissues.…”

Section: Health Effects Of European Elderberry and American Elderberrymentioning

confidence: 99%

“…The primary cause of aging and age-related diseases is cell senescence and, consequently, the accumulation of senescent cells in different tissues. Accelerated generation of ROS results in cellular senescence in addition to cellular apoptosis, necrosis, and autophagy [ 124 , 125 ]. Compelling evidence suggests that aging is the main risk factor in initiating many chronic diseases, disabilities, and declining health.…”

Section: Health Effects Of European Elderberry and American Elderberrymentioning

confidence: 99%

Elderberry Extracts: Characterization of the Polyphenolic Chemical Composition, Quality Consistency, Safety, Adulteration, and Attenuation of Oxidative Stress- and Inflammation-Induced Health Disorders

et al. 2023

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Elderberry is highly reputed for its health-improving effects. Multiple pieces of evidence indicate that the consumption of berries is linked to enhancing human health and preventing or delaying the onset of chronic medical conditions. Compared with other fruit, elderberry is a very rich source of anthocyanins (approximately 80% of the polyphenol content). These polyphenols are the principals that essentially contribute to the high antioxidant and anti-inflammatory capacities and the health benefits of elderberry fruit extract. These health effects include attenuation of cardiovascular, neurodegenerative, and inflammatory disorders, as well as anti-diabetic, anticancer, antiviral, and immuno-stimulatory effects. Sales of elderberry supplements skyrocketed to $320 million over the year 2020, according to an American Botanical Council (ABC) report, which is attributable to the purported immune-enhancing effects of elderberry. In the current review, the chemical composition of the polyphenolic content of the European elderberry (Sambucus nigra) and the American elderberry (Sambucus canadensis), as well as the analytical techniques employed to analyze, characterize, and ascertain the chemical consistency will be addressed. Further, the factors that influence the consistency of the polyphenolic chemical composition, and hence, the consistency of the health benefits of elderberry extracts will be presented. Additionally, adulteration and safety as factors contributing to consistency will be covered. The role of elderberry in enhancing human health alone with the pharmacological basis, the cellular pathways, and the molecular mechanisms underlying the observed health benefits of elderberry fruit extracts will be also reviewed.

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Ethnobotany, phytochemistry, pharmacology, and toxicology of the genus Sambucus L. (Viburnaceae)

Cited by 19 publications

References 101 publications

Anti-Aging Effects of Anthocyanin Extracts of Sambucus canadensis Caused by Targeting Mitochondrial-Induced Oxidative Stress

Anti-Aging Effects of Anthocyanin Extracts of Sambucus canadensis Caused by Targeting Mitochondrial-Induced Oxidative Stress

Walnut By-Products and Elderberry Extracts—Sustainable Alternatives for Human and Plant Health

Elderberry Extracts: Characterization of the Polyphenolic Chemical Composition, Quality Consistency, Safety, Adulteration, and Attenuation of Oxidative Stress- and Inflammation-Induced Health Disorders

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