Ethnobotany, Phytochemistry and Pharmacology of Uncaria (Rubiaceae)

Heitzman, Mary E.; Neto, Catherine C.; Winiarz, Elizabeth; Vaisberg, Abraham J.; Hammond, Gerald B.

doi:10.1002/chin.200517286

Cited by 144 publications

(223 citation statements)

References 1 publication

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“…This level of activity is consistent with signaling through a specific receptor. Studies describing the specific binding of tannic acid to CXCR4 show this interaction competitively inhibits CXCL12 binding at concentrations (IC 50 , 360 ng/ml) (70) similar to those we predict for the active component of APP. The restrictive pattern of gene regulation induced by APP in ␥␦ T cells, selective upregulation of IL-2R␣, CD69, MIP1␣, and GM-CSF shown in this study and by Graff and Jutila (43), is also consistent with a receptor-mediated event.…”

Section: Discussionsupporting

confidence: 64%

“…Limited work already published on the extracts examined in this study support the likelihood for success in these experiments. For instance, Cat's Claw is a traditional South American medicine used to treat a variety of illnesses including allergies, cancer, colitis, dysentery, and urinary tract infection (50). Interestingly, these illnesses are commonly associated with ␥␦ T cell regulatory activities (7,(51)(52)(53)(54), suggesting the described immunostimulatory properties of the Cat's Claw plant could be partially due to the activation of ␥␦ T cells.…”

Section: Discussionmentioning

confidence: 99%

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Select Plant Tannins Induce IL-2Rα Up-Regulation and Augment Cell Division in γδ T Cells

Holderness

Jackiw

Kimmel

et al. 2007

The Journal of Immunology

118

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γδ T cells are innate immune cells that participate in host responses against many pathogens and cancers. Recently, phosphoantigen-based drugs, capable of expanding γδ T cells in vivo, entered clinical trials with the goal of enhancing innate immune system functions. Potential shortcomings of these drugs include the induction of nonresponsiveness upon repeated use and the expansion of only the Vδ2 subset of human γδ T cells. Vδ1 T cells, the major tissue subset, are unaffected by phosphoantigen agonists. Using FACS-based assays, we screened primary bovine cells for novel γδ T cell agonists with activities not encompassed by the current treatments in an effort to realize the full therapeutic potential of γδ T cells. We identified γδ T cell agonists derived from the condensed tannin fractions of Uncaria tomentosa (Cat’s Claw) and Malus domestica (apple). Based on superior potency, the apple extract was selected for detailed analyses on human cells. The apple extract was a potent agonist for both human Vδ1 and Vδ2 T cells and NK cells. Additionally, the extract greatly enhanced phosphoantigen-induced γδ T cell expansion. Our analyses suggest that a tannin-based drug may complement the phosphoantigen-based drugs, thereby enhancing the therapeutic potential of γδ T cells.

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Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Select Plant Tannins Induce IL-2Rα Up-Regulation and Augment Cell Division in γδ T Cells

Holderness

Jackiw

Kimmel

et al. 2007

The Journal of Immunology

118

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“…Other classes of isolated compounds include terpenoids and terpenoid glycosides, flavonoids (specially flavanols and flavonols) and coumarins. 5,6 The South American species U. tomentosa and U. guianensis present some morphological differences 2,7 and U. tomentosa can be further identified by its oxindole alkaloid profile and content. 8 On the other hand, these alkaloids are present in U. guianensis at very low concentration 9,10 and no satisfactory chemical markers have been established for this species so far.…”

Section: Introductionmentioning

confidence: 99%

Kaempferitrin from Uncaria guianensis (Rubiaceae) and its potential as a chemical marker for the species

Valente¹,

Bizarri²,

Liechocki³

et al. 2009

J. Braz. Chem. Soc.

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Uncaria tomentosa (Willd.) DC. e U. guianensis (Aubl.) Gmel., conhecidas como unha-de-gato, são trepadeiras lenhosas nativas das florestas tropicais amazônica e central-americana. As espécies contêm, em diferentes proporções, alcalóides indólicos e oxindólicos, triterpenóides glicosilados, esteróides e proantocianidinas. U. tomentosa é quimicamente identificada pelo perfil e conteúdo de alcalóides oxindólicos, ao passo que U. guianensis não possui um marcador químico efetivo. Nesse trabalho descreve-se o isolamento de canferol-3,7-O-(α)-dirramnosídeo (canferitrina) pela primeira vez em espécies do gênero Uncaria. A triagem para essa substância em folhas, galhos ou cascas das duas espécies por CCD e CLAE-DAD-EM demonstrou a presença de canferitrina apenas nas folhas e galhos de U. guianensis, numa proporção cerca de trinta e seis vezes maior nas folhas do que nos galhos. Estes resultados revelaram a seletividade da U. guianensis em produzir o flavonóide glicosilado, sugerindo esta substância como um marcador químico potencial para a espécie.Uncaria tomentosa (Willd.) DC. and U. guianensis (Aubl.) Gmel., known as cat's claw, are large woody vines native to the Amazonian and Central American rainforests. The species contain, in different proportions, indole and oxindole alkaloids, triterpenoid glycosides, sterols and proanthocyanidins. U. tomentosa can be chemically identified by its oxindole alkaloid profile and content, whereas U. guianensis has no satisfactorily established chemical markers. This work describes, for the first time, the isolation of kaempferol-3,7-O-(α)-dirhamnoside (kaempferitrin) in Uncaria species. Screening for this compound in leaves, stems or bark of both species through TLC and HPLC-DAD-MS showed the presence of kaempferitrin only in the leaves and stems of U. guianensis, at a ratio almost thirty six times greater in the leaves than in the stems. These results reveal the selectivity of U. guianensis to produce this bioactive flavonoid glycoside, and suggest this compound as a potential chemical marker for the species.

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“…The plant is widely studied due to its medicinal properties, ecological and economic value. [4][5][6][7][8][9] Both Uncaria tomentosa (Willdenow ex Roemer and Schultes) DC. and Uncaria guianensis (Aublet) Gmell., from the Rubiaceae family, have been used by indigenous healers of tropical South America for the treatment of uncountable diseases and affections.…”

Section: Introductionmentioning

confidence: 99%

“…[9] The last ones constitute the most relevant group of bioactive components in cat's claw, as they appear in the plant in strange abundance, and are well recognized as potent medicinal compounds with herbal origin [17][18][19]10]. Alcaloids can be potent drugs and poisons depending on the concentration and type, boh found in tetracyclic and pentacyclic forms as well.…”

Section: Introductionmentioning

confidence: 99%

Controlling concentration of bioactive components in cat's claw based products with a hybrid separation process

Calvo

Dévényi

Kószó

et al. 2017

The Journal of Supercritical Fluids

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Supercritical fluid extraction (SFE) with and without entrainer combined with organic solvent extraction was used for fractionation of bioactive natural products as alkaloids and antioxidants from cat's claw (Uncaria tomentosa (Willd.) DC.) bark. Extracts obtained from this plant have a number of beneficial effects, including anti-inflammatory or immune stimulator. The aim of this work was to obtain extracts of enriched and limited alkaloid concentrations, good antioxidants and tannin agents. The results demonstrated that a hybrid process involving SFE is a selective method to obtain an oxindole alkaloid rich fraction (186.0 ± 3.2 mg total pentacyclic oxindole alkaloids/g extract) and a product enriched in tannins (23.8 ± 1.9 % tannin content in extract) and antioxidants (IC50 = 5.88 ± 0.54 µg/ml extract).

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Ethnobotany, Phytochemistry and Pharmacology of Uncaria (Rubiaceae)

Abstract: For Abstract see ChemInform Abstract in Full Text.

Cited by 144 publications

References 1 publication

Select Plant Tannins Induce IL-2Rα Up-Regulation and Augment Cell Division in γδ T Cells

Select Plant Tannins Induce IL-2Rα Up-Regulation and Augment Cell Division in γδ T Cells

Kaempferitrin from Uncaria guianensis (Rubiaceae) and its potential as a chemical marker for the species

Controlling concentration of bioactive components in cat's claw based products with a hybrid separation process

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