Ethnobotanical Uses, Phytochemistry and Pharmacology of Different Rheum Species (Polygonaceae): A Review

Mohtashami, Leila; Amiri, Mohammad Sadegh; Ayati, Zahra; Ramezani, Mohammad; Jamialahmadi, Tannaz; Emami, Seyed Ahmad; Sahebkar, Amirhossein

doi:10.1007/978-3-030-64872-5_22

Cited by 16 publications

(15 citation statements)

References 101 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Polygonum is an annual genus of Polygonaceae, which are broadly spread around the world, and most of them are distributed in the north temperate zone ( Macêdo et al, 2021 ; Mohtashami et al, 2021 ; Song et al, 2020 ). Moreover, there are about 113 species in China.…”

Section: Introductionmentioning

confidence: 99%

A Comparative Analysis of the Chloroplast Genomes of Four Polygonum Medicinal Plants

et al. 2022

View full text Add to dashboard Cite

Polygonum is a generalized genus of the Polygonaceae family that includes various herbaceous plants. In order to provide aid in understanding the evolutionary and phylogenetic relationship in Polygonum at the chloroplast (cp) genome-scale level, we sequenced and annotated the complete chloroplast genomes of four Polygonum species using next-generation sequencing technology and CpGAVAS. Then, repeat sequences, IR contractions, and expansion and transformation sites of chloroplast genomes of four Polygonum species were studied, and a phylogenetic tree was built using the chloroplast genomes of Polygonum. The results indicated that the chloroplast genome construction of Polygonum also displayed characteristic four types of results, comparable to the published chloroplast genome of recorded angiosperms. The chloroplast genomes of the four Polygonum plants are highly consistent in genome size (159,015 bp–163,461 bp), number of genes (112 genes, including 78 protein-coding genes, 30 tRNA genes, and 4 rRNA genes), gene types, gene order, codon usage, and repeat sequence distribution, which identifies the high preservation among the Polygonum chloroplast genomes. The Polygonum phylogenetic tree was recreated by a full sequence of the chloroplast genome, which illustrates that the P. bistorta, P. orientale, and P. perfoliatum are divided into the same branch, and P. aviculare belongs to Fallopia. The precise system site of lots base parts requires further verification, but the study would provide a basis for developing the available genetic resources and evolutionary relationships of Polygonum.

show abstract

Section: Introductionmentioning

confidence: 99%

A Comparative Analysis of the Chloroplast Genomes of Four Polygonum Medicinal Plants

et al. 2022

View full text Add to dashboard Cite

show abstract

“…undulatum ) and rhapontic ( R. rhaponticum ) rhubarbs are primarily used as foods, while their underground parts provide herbal material. The current knowledge of phytochemical profile, ethnomedicinal relevance and main directions of physiological activity of individual compounds and extracts originated from R. rhaponticum and R. rhabarbarum and other rhubarbs have been extensively reviewed elsewhere [ 6 , 7 , 8 , 9 ]. Hence, in this paper, these issues have been only briefly mentioned.…”

Section: Rhubarbs As Ethnomedicinal Plantsmentioning

confidence: 99%

A Review on Rhubarb-Derived Substances as Modulators of Cardiovascular Risk Factors—A Special Emphasis on Anti-Obesity Action

Liudvytska

Kołodziejczyk-Czepas

2022

Nutrients

View full text Add to dashboard Cite

The currently available anti-obesity therapies encounter many associated risks and side effects often causing the ineffectiveness of treatment. Therefore, various plant-derived substances have been extensively studied as a promising support or even an alternative for existing anti-obesity therapies. This review is dealing with the anti-obesity potential of edible and ethnomedicinal rhubarb species and emerging possible role of the rhubarb-derived extracts or individual compounds in the prevention of obesity and perspectives for their use in an anti-obesity treatment. A special emphasis is put on the most popular edible specimens, i.e., Rheum rhabarbarum L. (garden rhubarb) and Rheum rhaponticum L. (rhapontic rhubarb, Siberian rhubarb); however, the anti-obesity potential of other rhubarb species (e.g., R. officinale, R. palmatum, and R. emodi) is presented as well. The significance of rhubarb-derived extracts and low-molecular specialized rhubarb metabolites of diversified chemical background, e.g., anthraquinones and stilbenes, as potential modulators of human metabolism is highlighted, including the context of cardiovascular disease prevention. The available reports present multiple encouraging rhubarb properties starting from the anti-lipidemic action of rhubarb fibre or its use as purgative medicines, through various actions of rhubarb-derived extracts and their individual compounds: inhibition of enzymes of cholesterol and lipid metabolism, targeting of key molecular regulators of adipogenesis, regulators of cell energy metabolism, the ability to inhibit pro-inflammatory signalling pathways and to regulate glucose and lipid homeostasis contributing to overall in vivo and clinical anti-obesity effects.

show abstract

“…The roots and rhizomes of R. tanguticum have been utilized as well known traditional Chinese medicine for the treatment of gastrointestinal diseases [ 2 ], which have also been used as functional and healthy food ingredients in China. Generally, R. tanguticum contains various bioactive components, such as polysaccharides, flavonoids, anthraquinones, saponins, tannins, and volatile oils [ 1 – 4 ], which contribute to its multiple pharmacological activities of purgative, immunomodulatory, anti-oxidant, anti-inflammatory, anti-diabetic, anti-fungal, hepatoprotective, anti-tumor, and nephroprotective effects. Especially, R. tanguticum polysaccharides have received increasing attention due to its diversely pharmacological activities, such as immunomodulatory effect, ameliorating radiation-induced intestinal injury, preventing radiation-induced immune damage, and ameliorating inflammatory bowel disease [ 5 – 8 ].…”

Section: Introductionmentioning

confidence: 99%

Fecal fermentation characteristics of Rheum tanguticum polysaccharide and its effect on the modulation of gut microbial composition

Yuan

Feng

et al. 2022

Chin Med

View full text Add to dashboard Cite

Background Rheum tanguticum is utilized as one of the well known traditional Chinese medicine for the treatment of gastrointestinal diseases. Recently, R. tanguticum polysaccharides (RP) have received increasing attention due to their diversely pharmacological activities. Usually, the pharmacological activities of polysaccharides are closely correlated to their metabolic properties from the stomach to the intestine. However, the digestive behavior and fecal fermentation characteristics of RP are unknown, which need to be fully investigated. Methods In this study, an in vitro simulated gastrointestinal model was carried out for the investigation of the digestive behavior and fecal fermentation characteristics of RP. The possible changes in physicochemical properties of RP, such as molecular weight, monosaccharide composition, reducing sugar released, chemical composition, pH value, and short chain fatty acids, were determined during in vitro simulated digestion and human fecal fermentation, and its effect on the modulation of gut microbial composition was also evaluated. Results The results revealed that RP was indigestible under the in vitro simulated digestion conditions according to its stabilities in physicochemical properties. Conversely, the indigestible RP (RPI) could be notably utilized by colonic microbiota in human feces after the in vitro fermentation, especially, at the initial fermentation stage (0–6 h). The fecal fermentation characteristics of RPI were revealed. Results showed that the content of reducing sugars obviously increased from 0.177 to 0.778 mg/mL at the initial stage of fermentation, and its molecular weight notably declined from 2.588 × 105 to 0.828 × 105 Da at the end stage of fermentation. Notably, the utilization of arabinose and galactose in RPI by colonic bacteria was faster than that of galacturonic acid. Besides, RPI could obviously modulate gut microbial composition via promoting the relative abundances of several beneficial bacteria, such as genera Bacteroides, Bifidobacterium, and Megamonas, resulting in the promoted production of several short-chain fatty acids, such as acetic, propionic, and butyric acids. Conclusions Results from this study showed that RP was indigestible in the human upper gastrointestinal tract in vitro, but could be easily utilized by colonic microbiota in human feces at the initial stage of fermentation. RP could be used as potential prebiotics for the improvement of intestinal health.

show abstract

Ethnobotanical Uses, Phytochemistry and Pharmacology of Different Rheum Species (Polygonaceae): A Review

Cited by 16 publications

References 101 publications

A Comparative Analysis of the Chloroplast Genomes of Four Polygonum Medicinal Plants

A Comparative Analysis of the Chloroplast Genomes of Four Polygonum Medicinal Plants

A Review on Rhubarb-Derived Substances as Modulators of Cardiovascular Risk Factors—A Special Emphasis on Anti-Obesity Action

Fecal fermentation characteristics of Rheum tanguticum polysaccharide and its effect on the modulation of gut microbial composition

Contact Info

Product

Resources

About