Ethnobotanical studies from central Nigeria

Bhat, RB; Etejere, E. O.; Oladipo, V. T.

doi:10.1007/bf03183923

Cited by 81 publications

(40 citation statements)

References 5 publications

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“…More recent studies also revealed that the methanol extract of the root bark has analgesic and anti-inflamatory activities [45], proteins, amino acids and antraquinones [14,19,46], sterol, terpenoids, acetogenins [48][49][50][51] diterpenes [52], wax and alkaloids [53,54]. The leaf extracts contains anthraquinones and cardiac glycosides.…”

Section: Discussionmentioning

confidence: 99%

“…The plant is reputed to be of great medicinal value and is used in native medicine [12]. It have been used against snake venom [13,14], for chest pain, coughs, anemia, urinary tract infection [15,16], venereal diseases [17,18], anthritis and rheumatism [19], diarrohea and dysentery [20][21][22], against malaria [23], head and body ache [24,25] anti-bacterial [26], against leishmaniasis [27], against typanasomiasis [28], eyelid swelling [29] Antiprotozoan [30], antitumor agent [31,32], molluscisidal [33] antiulcer/antacid, smooth muscle relaxant [34], anthelmintic activity [35] and also for cancer treatment [17,36]. A lot of scientific studies have been done and reported concerning its medicinal values but none so far on skin ailments caused by the fungus Melassezia globosa.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of Anti-Fungal Activity of Annona senegalensis Plant Parts on Malassezia globosa

Anthony¹,

Саид²,

Hamisi³

et al. 2017

Nat Prod Chem Res

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The pondered parts (mixture of fresh leaves, twigs & soft stem barks and soft root extract) of Annona senegalensis plant have been used as ethno-medicine for treating patients suffering from tinea versicolor. The antifungal activities of dichloromethane and methanol (1:1), methanol, water, acetone, ethanol, ether and chloroform extracts of Annona senegalensis (Annonaceae) parts were investigated and primarily assessed against cultured Malassezia globosa fungus isolated from willing tinea versicolor patients. The efficacy of the extracts was studied and determined by applying different extracts concentrations on agar slants carrying the fungus in an incubator. The susceptibility of tested fungus on the extracts was determined by measuring the diameter of inhibition zones formed around the disc. The highest anti-fungal activity was observed in methanol fresh leaf extract gave an inhibition zone of 9.667 ± 0.557 mm while methanol twigs and soft bark extract gave lowest inhibition zone of 4.333 ± 0.5773 mm compare with gentamycin which gave an inhibition zone of 15 mm after 24 hours. Thus combination of the mixtures confirms the antifungal synergistic interaction against the Malassezia globosa fungus. The water, acetone, ethanol, ether and chloroform plant extracts showed no inhibition zones hence proved ineffective at the evaluated concentrations. The preliminary phytochemical screening of the plant parts also indicated the presence of the relevant phytochemical constituents, thus supports its medicinal values.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Assessment of Anti-Fungal Activity of Annona senegalensis Plant Parts on Malassezia globosa

Anthony¹,

Саид²,

Hamisi³

et al. 2017

Nat Prod Chem Res

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“…Algumas das espécies apresentam importância econômica, pois fornece o látex usado na produção de goma comercial, madeira de qualidade, matéria-prima para especiarias e frutos comestíveis (Pennington, 1990), além de serem utilizadas na medicina popular para os mais variados fi ns, tais como malária (Bhat et al, 1990), hanseníase (Nwude;Ebong, 1980), febres e resfriados (Gill;Akinwumi, 1986), infl amação ovariana e diabetes (Desmarchelier et al, 1999;Pereira et al, 2004). A literatura reporta para algumas espécies atividades antibacteriana (Kudi et al, 1999;Ogunwande et al, 2001), antifúngica (Ogunwande et al, 2001), antiviral (Khurana, 1972), antitumoral (Suffness et al, 1988), analgésica (Almeida et al, 1985;Pal;Nandy, 1999), tripanosomicida (Muelas-Serrano et al, 2000), antipirética e antiinfl amatória (Pal;Nandy, 1999;Falcão et al, 2005), antiespasmolítica, anticonvulsivante, depressora do SNC e anti-hiperglicêmica (Almeida et al, 1985;Naik et al, 1991;Barbosa-Filho et al, 2005), entre outras.…”

Section: Introductionunclassified

Terpenóides e avaliação do potencial antimalárico, larvicida, anti-radicalar e anticolinesterásico de Pouteria venosa (Sapotaceae)

Montenegro¹,

Oliveira²,

Conserva³

et al. 2006

Rev. bras. farmacogn.

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RESUMO:O presente trabalho descreve o isolamento de quatro triterpenos (taraxerol, ácido ursólico, ácido 3β,19α,23-triidroxiurs-12-en-28-óico e ácido 2α,3α,19α,23-tetraidroxiurs-12-en-28-óico) e um fi toesteróide (espinasterol), bem como a avaliação do potencial antimalárico (cepa NK-65 do Plasmodium berghei), larvicida (larvas do 4º instar do Aedes aegypti), anti-radicalar (2,2-difenil-1-picril-hidrazila, DPPH) e anticolinesterásico de extratos das folhas, cascas do caule e caule de Pouteria venosa (Mart.) Baehni. Todos os compostos isolados estão sendo descritos pela primeira vez nesta espécie e foram identifi cados com base na análise de dados espectrais (IV e RMN, incluindo APT e DEPT), bem como pela comparação com dados descritos na literatura.Unitermos: Pouteria venosa, terpenóides, anticolinesterase, anti-radicalar, malária, larvicida.ABSTRACT: "Terpenoids and evaluation of the antimalarial, larvicidal, anti-radicalar and anticholinesterase potential of Pouteria venosa (Sapotaceae)". This work describes the isolation of four triterpenes (taraxerol, ursolic acid, 3β,19α,23-trihydroxyurs-12-en-28-oic acid and 2α,3α,19α,23-tetrahydroxyurs-12-en-28-oic acid) and a phytosteroid (spinasterol), as well as a preliminary evaluation of antimalarial (NK-65 strains of Plasmodium berghei), larvicidal (4 th instar of Aedes aegypti), anti-radicalar (2,2-diphenyl-1-pycryl-hydrazyl, DPPH) and anticholinesterase activities of Pouteria venosa (Mart.) Baehni extracts from leaves, stem barks and stems. All isolated compounds are being described for the fi rst time in this species and were identifi ed on basis of the spectral data (IR and NMR, including APT, DEPT), as well as by comparison with literature data

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Section: Abstract: Apoptosis Anticancer Cantharidin Caspase Tamamentioning

confidence: 99%

“…The bark of tamarind tree was reported as to have antiinflammatory, analgesic and wound healing properties [9,10] . In West Africa, the macerated fresh bark of the young twigs was used both as a purgative and to relieve abdominal pain [11] .Cantharidin is a colorless, odourless terpene secreted by many species of blister beetles. Cantharidin, isolated from the Chinese blister beetles, Mylabris phalerata or M. cichorii, displays antitumor activity and induces apoptosis in many types of tumor cells.…”

mentioning

confidence: 99%

Tamarindus indica Bark Extract and its Bioactive Fraction Induce Apoptosis in HeLa and PA-1 Cells

Shirisha¹,

Varalakshmi²

2016

pharmaceutical-sciences

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The aim of the current study was to evaluate the anticancer potential of tamarind bark and its bioactive fraction on HeLa and PA-1 cell lines. Tamarind bark extract was prepared with dichloromethane as the solvent using Soxhlet apparatus and treated on HeLa and PA-1 cell lines to determine the anticancer potential by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Further, bioassay guided fractionation of the extract was carried out using thin layer chromatography. In vitro assays like fluorescence microscopy, DNA fragmentation analysis, caspase-9 activity assay and flow cytometry analyses were carried out to determine the mechanism of anticancer activity of the selected bioactive fraction. The fraction was further characterized by gas chromatography-mass spectrometry. Tamarind bark dichloromethane extract was found to be cytotoxic to HeLa and PA-1 cells. Bioassay guided fractionation indicated that the fourth fraction of the extract possessed the bioactive component. Further, in vitro assays demonstrated that the bioactive fraction induced caspase-9-mediated apoptosis in the cells and was able to reduce the total cell count as evidenced by flow cytometry analyses. The gas chromatography-mass spectrometry analysis of the bioactive fraction indicated the presence of cantharidin, an anticancer compound earlier reported from the blister beetles. It can be concluded that the presence of cantharidin might be responsible for inhibition of proliferation and induction of apoptosis in the cancer cells. Key words: Apoptosis, anticancer, cantharidin, caspase, tamarind bark extractCancer is one of the most dreaded diseases as mortality associated is very high despite the availability of modern treatment modalities [1,2] . Hence, research towards novel, more effective and tumor-specific treatment has gained momentum during the past decades. In this pursuit, several medicinal and dietary plants have provided many anticancer compounds till date [3,4] . Tamarindus indica L. commonly known as tamarind is one of the most important dietary plants in which all parts have some nutritional or medicinal value. It has a history that dates back to ancient tribal people who used to prepare decoctions of the parts and use it for medication. It was reported that tamarind bark and leaves were used to treat wounds in West and East Africa [5] . Fruit and leaf have laxative property, paste of dried seeds were used to set fractured bones, and decoction of the bark and leaves were used to treat jaundice [6][7][8] . The bark of tamarind tree was reported as to have antiinflammatory, analgesic and wound healing properties [9,10] . In West Africa, the macerated fresh bark of the young twigs was used both as a purgative and to relieve abdominal pain [11] .Cantharidin is a colorless, odourless terpene secreted by many species of blister beetles. Cantharidin, isolated from the Chinese blister beetles, Mylabris phalerata or M. cichorii, displays antitumor activity and induces apoptosis in many types of tumor cells. It can be poisono...

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Ethnobotanical studies from central Nigeria

Cited by 81 publications

References 5 publications

Assessment of Anti-Fungal Activity of Annona senegalensis Plant Parts on Malassezia globosa

Assessment of Anti-Fungal Activity of Annona senegalensis Plant Parts on Malassezia globosa

Terpenóides e avaliação do potencial antimalárico, larvicida, anti-radicalar e anticolinesterásico de Pouteria venosa (Sapotaceae)

Tamarindus indica Bark Extract and its Bioactive Fraction Induce Apoptosis in HeLa and PA-1 Cells

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