Ethnobotanical, phytochemistry, toxicological and pharmacological significance of the underutilized indigenous Aloe species of West Africa

Singh, Karishma; Ajao, Abdulwakeel Ayokun-nun; Sabiu, Saheed

doi:10.1016/j.sajb.2021.12.014

Cited by 5 publications

(4 citation statements)

References 36 publications

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“…The ferric chloride test exhibited the presence of phenols, whereas the foam test showed the presence of saponins. Eight classes (alkaloids, flavonoids, glycosides, saponins, sterols, terpenoids, phenols and fixed oils and fats) of phytocompounds were found in the leaf extract of A. ferox across the study sites, which was consistent with the previous studies (Nalimu et al 2021;Singh et al 2021;Svitina, Hamman & Gouws 2021). The leaf extracts also revealed the presence of fixed oils and fats.…”

Section: Resultssupporting

confidence: 90%

“…The genus Aloe in the family Xanthorrhoeaceae comprises over 560 species ranging from small shrub-like plants to large trees (Singh, Ajao & Sabiu 2021). Aloe ferox, commonly known as Cape aloe or bitter aloe, is regarded as an important medicinal plant indigenous to South Africa and has many medicinal benefits.…”

Section: Introductionmentioning

confidence: 99%

“…Also, the correlation between different geographic regions and variations in plant phytochemicals has received less attention. compounds that are of medicinal value (Singh et al 2021). Aloin and anthraquinone have been reported to be present in A. ferox (Nalimu et al 2021).…”

Section: Introductionmentioning

confidence: 99%

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Pytochemical profile of Aloe ferox Mill. across different regions within South Africa

Goge

Singh

Komoreng

et al. 2023

JOMPED

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Background: Aloe ferox is an indigenous medicinal plant that is widely used for its various medicinal and pharmacological properties. Despite the medicinal importance and various applications of the species, it is surprising that little is known about the extent of geographical differences in its major chemical compounds. Also, the correlation between different geographic regions and variations in plant phytochemicals has received less attention.Aim: This study sought to investigate the presence of biologically active compounds in the leaf extracts of A. ferox from different geographical regions across South Africa.Setting: This study was set in different regions within South Africa.Methods: Phytochemical screening was performed qualitatively using established standard procedures involving chemical reagents such as hexane, chloroform and methanol and a series of reactions to determine the presence of phytocompounds of biological importance.Results: The study revealed that A. ferox leaves possess several classes of phytocompounds such as alkaloids, tannins, terpenoids, glycosides, phenolics, flavonoids, saponins and fixed oils and fats across various samples. Mucilage was absent across the samples.Conclusion: The study revealed eight classes of phytochemical compounds present on A. ferox leaves in three different geographic regions, which is consistent with the previous studies; however, further research is needed to enhance the study through qualitative research, gas chromatography–mass spectrometry and high-performance liquid chromatography analyses to validate phytochemical variations and their therapeutic effects.Contribution: This study contributes to the existing knowledge of the therapeutic Aloe genus.

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Section: Resultssupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

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Pytochemical profile of Aloe ferox Mill. across different regions within South Africa

Goge

Singh

Komoreng

et al. 2023

JOMPED

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“…49 Several Aloe species have been found to be beneficial in the treatment of fungal infections such as dandruff. 16,50 The antifungal efficacy of A. adigratana leaf latex and gel extracts against three clinical fungal species, M. globosa, M. furfur, and M. restricta, was examined using well diffusion technique. A. adigratana leaf latex and gel extracts inhibited the development of all Malassezia fungi at concentrations as low as 62.5 mg/mL (Table 4 and 5).…”

Section: Antifungal Activitiesmentioning

confidence: 99%

Aloe adigratana Reynolds: Preliminary Phytochemical Screening, Proximate Content, Essential Oil Analysis, and In Vitro Antifungal Activity Studies of Its Leaf Peels and Gel

Gebremariam,

Gebrezgabher,

Desta

et al. 2023

JEP

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Background: Aloe species are among the most significant plants with several applications. Many of the species, however, are underexplored, owing to their scarcity and limited geographical distribution. A. adigratana Reynolds, which is common in Ethiopia, is one of the little-studied and endangered Aloe species. Objective: This preliminary study focuses on the phytochemical screening, proximate analysis, essential oil content, and antifungal activities of A. adigratana leaf peels. Antifungal activities were also tested on the gels of the plant for comparison. Methods: Standard procedures were used for phytochemical and proximate composition studies. Essential oil analysis was performed using a gas chromatography-mass spectrometry instrument. Using the well-diffusion method, investigations on antifungal activity were performed on three clinically isolated specimens of dandruff-causing fungus; namely, Malassezia furfur, Malassezia restricta, and Malassezia globosa. Results: The leaf peels of A. adigratana contained alkaloids, flavonoids, tannins, and terpenes. The mean moisture, ash, and crude fat levels were 85.69, 92.20, and 8.00%, respectively, whereas the mean total protein and mean total carbohydrate values were 2.59 and 3.04%. Gas chromatography-mass spectrometry investigation confirmed the presence of fifteen essential oils. The most prevalent essential oil component was discovered to be phytol (33.78%), followed by decane (11.29%). In a dose-dependent way, the leaf latex and gel extracts prevented the growth of three dandruff-causing Malassezia fungal species (M. furfur, M. restricta, and M. globosa). Both the latex and gel demonstrated the maximum activity on M. globosa, the most prevalent fungus in the research area, with minimum inhibitory concentrations of 0.24 and 0.48 mg/mL and minimum fungicidal concentrations of 0.48 and 0.97 mg/mL, respectively. Conclusion:In general, the proximate and essential oil compositions of A. adigratana leaves were comparable to those of other Aloe species widely used in the food, cosmetic, and pharmaceutical industries, implying that A. adigratana could be a potential future plant for such industries.

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A review on the medicinal applications of flavonoids from aloe species

Tizazu,

Bekele

2024

European Journal of Medicinal Chemistry Reports

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Ethnobotanical, phytochemistry, toxicological and pharmacological significance of the underutilized indigenous Aloe species of West Africa

Cited by 5 publications

References 36 publications

Pytochemical profile of Aloe ferox Mill. across different regions within South Africa

Pytochemical profile of Aloe ferox Mill. across different regions within South Africa

Aloe adigratana Reynolds: Preliminary Phytochemical Screening, Proximate Content, Essential Oil Analysis, and In Vitro Antifungal Activity Studies of Its Leaf Peels and Gel

A review on the medicinal applications of flavonoids from aloe species

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