Ethnobotanical, Phytochemical, and Pharmacological Properties of the Subfamily Nepetoideae (Lamiaceae) in Inflammatory Diseases

Ortiz-Mendoza, Nancy; Martínez-Gordillo, Martha Juana; Martínez-Ambriz, Emmanuel; Basurto-Peña, Francisco Alberto; González-Trujano, María Eva; Aguirre-Hernández, Eva

doi:10.3390/plants12213752

Cited by 4 publications

(1 citation statement)

References 199 publications

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“…The Lamiaceae family, which consists of plants and shrubs, is composed of approximately 258 genera and 7193 species. In Brazil, over 500 species from the Lamiaceae family are distributed across 46 genera, with nearly half of these species belonging to the subfamily Nepetoideae [ 1 , 2 ], which is a well-known source of abietane-type diterpenoids [ 3 , 4 ]. The broad spectrum of biological activities associated with these compounds has garnered special attention, with many demonstrating anti-inflammatory [ 5 ], anticancer [ 6 ], antimicrobial [ 7 ], and antiprotozoal [ 8 ] properties.…”

Section: Introductionmentioning

confidence: 99%

Abietane Diterpenes from Medusantha martiusii and Their Anti-Neuroinflammatory Activity

Assis,

Andrade,

Silva

et al. 2024

Molecules

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Seven new abietane diterpenoids, comprising medusanthol A–G (1–3, 5, 7–9) and two previously identified analogs (4 and 6), were isolated from the hexane extract of the aerial parts of Medusantha martiusii. The structures of the compounds were elucidated by HRESIMS, 1D/2D NMR spectroscopic data, IR spectroscopy, NMR calculations with DP4+ probability analysis, and ECD calculations. The anti-neuroinflammatory potential of compounds 1–7 was evaluated by determining their ability to inhibit the production of nitric oxide (NO) and the proinflammatory cytokine TNF-α in BV2 microglia stimulated with LPS and IFN-γ. Compounds 1–4 and 7 exhibited decreased NO levels at a concentration of 12.5 µM. Compound 1 demonstrated strong activity with an IC50 of 3.12 µM, and compound 2 had an IC50 of 15.53 µM; both compounds effectively reduced NO levels compared to the positive control quercetin (IC50 11.8 µM). Additionally, both compounds significantly decreased TNF-α levels, indicating their potential as promising anti-neuroinflammatory agents.

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Section: Introductionmentioning

confidence: 99%

Abietane Diterpenes from Medusantha martiusii and Their Anti-Neuroinflammatory Activity

Assis,

Andrade,

Silva

et al. 2024

Molecules

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Multivariate analysis of the phytochemical composition and antioxidant properties in twenty-five accessions across three Achillea species

Farajpour,

Ebrahimi,

Sadat-Hosseini

et al. 2024

Sci Rep

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This study explored the chemical composition, antioxidant activity, and total phenol content of aerial parts from 25 accessions of three Achillea species (Achillea wilhelmsii C. Koch, Achillea vermicularis Trin., and Achillea tenuifolia Lam.). The plants were collected from various natural habitats across Iran, encompassing regions such as Central, Western, Southern, Northern, Western, and Northwestern parts of the country. Subsequently, they were grown together under field conditions. The study revealed significant variation in essential oil yields among accessions of A. wilhelmsii, ranging from 0.01 to 0.107%, A. vermicularis with a range of 0.075 to 1.5%, and A. tenuifolia showing a variation of 0.1 to 2%. The study utilized Gas Chromatography–Mass Spectrometry (GC–MS) analysis, revealing 75, 49, and 75 compounds in the essential oils of A. wilhelmsii, A. tenuifolia, and A. vermicularis, respectively. Major components included camphor, 1,8-cineole, anethole, α-pinene, and phytol in A. wilhelmsii, 1,8-cineole, camphor, levo-carvone, and δ-terpinene in A. vermicularis, and β-cubebene, elixene, β-sesquiphellandrene, 1,8-cineole, camphor, and δ-terpinene in A. tenuifolia. The essential oil compositions of A. wilhelmsii and A. vermicularis were predominantly characterized by oxygenated monoterpenes, whereas that of A. tenuifolia was characterized by sesquiterpenes. Cluster analysis grouped accessions into three clusters, with A. tenuifolia forming a distinct group. Principal Component Analysis (PCA) triplot (62.21% of total variance) confirmed these results and provided insights into compound contributions. Furthermore, total phenolic content and antioxidant activity of the accessions of three species were assessed over 2 years. A. tenuifolia exhibited the highest levels in both categories, with statistically significant linear regression between antioxidant activity and total phenol content for A. tenuifolia and A. wilhelmsii. These findings emphasize significant phytochemical diversity within Achillea species, positioning them as promising natural sources of antioxidants. Further exploration and selection of specific accessions within each species are crucial for unlocking their medicinal potential and supporting cultivation and conservation efforts.

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Sustainable use of economically valuable and conservation of rare plant species in Almaty region

Sitpayeva,

Gemejiyeva,

Vesselova

et al. 2024

BIO Web Conf.

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The paper contains the results of the initial cadastral survey and integrated assessment of the components of the flora (plant resources, higher plants and algae) of the Almaty region (2021–2023), which occupies a leading position among the economically developed regions of the country. The reserves of raw materials of 18 plant species demanded by the domestic pharmaceutical industry discovered on the territory of 13 administrative districts are of practical value. Eleven species of medicinal plants can be recommended for industrial harvesting. It is important to note that conservation efforts are required to protect 118 rare species of higher vascular plants and three species of lower plants, such as algae – indicating the vegetation’s current condition in the region. For the first time, the region’s list of rare flora species includes 13 species that have been categorized into IV categories based on the criteria and categories of the Red List of the International Union for Conservation of Nature. The results obtained will serve as a scientific basis for regular monitoring and forecasting of effective environmental activities that ensure the sustainable use and conservation of plant resources in the region.

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Ethnobotanical, Phytochemical, and Pharmacological Properties of the Subfamily Nepetoideae (Lamiaceae) in Inflammatory Diseases

Cited by 4 publications

References 199 publications

Abietane Diterpenes from Medusantha martiusii and Their Anti-Neuroinflammatory Activity

Abietane Diterpenes from Medusantha martiusii and Their Anti-Neuroinflammatory Activity

Multivariate analysis of the phytochemical composition and antioxidant properties in twenty-five accessions across three Achillea species

Sustainable use of economically valuable and conservation of rare plant species in Almaty region

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