Ethnobotanical and antibacterial study of Primula plants traditionally used in the indigenous communities of Western Himalaya, Pakistan

Khan, Saima; Shaheen, Hamayun; Mehmood, Ahmer; Nasar, S. A. K.; Khan, Tehreem A.

doi:10.1016/j.sjbs.2022.01.048

Cited by 12 publications

(11 citation statements)

References 37 publications

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“…This study was compared with previously published literature of neighboring areas and distant areas of utilization of medicinal plants for ethogynecological disorders (Quershi et al 2009;Mir et al 2022;Khan et al 2015;. The comparative study between previously reported medicinal plants showed that some medicinal plants have the same or different medicinal uses, while some were documented for the first time and others were not previously documented.…”

Section: Novelty and Future Impactsmentioning

confidence: 92%

Medicinal plants used against gynecological disorders by the local inhabitants of District Budgam, Kashmir Himalaya

Niyaz,

Andrabi,

Mir

2023

Ethnobot. Res. App.

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Background: Medicinal plants are an essential part of the human health care system and are used to treat a variety of gynecological issues. Due to low living standards, famine, and strenuous physical labor, rural women frequently experience gynecological issues, even while pregnant. The objective of this study was to document the indigenous knowledge of local flora indigenous knowledge on the treatment of various gynecological disorders in the district Budgam, Jammu and Kashmir.Methods: To assess the medicinal plants' utility in the region, a quantitative analysis including the Use value (UV) and Family use value (FUV) was carried out. Key informants were interviewed through semi-structured interviews, as well as group discussions.Results: A total of 51 medicinal plant species from 28 families are used to treat 33 distinct gynecological disorders. Among these families; Asteraceae was the dominant family (08 species).The leaves were the most commonly used part (34%). Herbs dominated all other life forms by (36 species).The most typical way to consume the medications was by decoction 39%, (32 species).According to the current study; the most prevalent disease addressed by the medicinal plants included is menstrual problems (36%). The Highest (UV of 0.65) were calculated for Artemisia absinthium while as the lowest (UV of 0.21) for Celtis australis. The highest family use value (FUV) was reported for Asparagaceae (0.50) while as the lowest FUV was calculated for Amaranthaceae (0.31). Locals continue to value herbal treatments as a trustworthy means of curing a variety of ailments.Conclusions: The current study demonstrates that rural women frequently experience gynecological problems and depend on traditional medical care. The result also indicates that the local population is sensitive and careful about gynecological diseases. This study is providing a baseline for future pharmacological studies to discover new herbal drugs to treat a variety of gynecological issues.

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Section: Novelty and Future Impactsmentioning

confidence: 92%

Medicinal plants used against gynecological disorders by the local inhabitants of District Budgam, Kashmir Himalaya

Niyaz,

Andrabi,

Mir

2023

Ethnobot. Res. App.

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“…The reference standards used for compound identification were obtained as follows: protocatechuic acid (1), 4 -hydroxyflavone (6), apigenin (9), luteolin (11), kaempferol (12), quercetin (13), rhamnetin (16), isorhamnetin (17), apigenin 7-O-glucoside (22), luteolin 7-O-glucoside (24), kaempferol 3-O-glucoside (26), myricitrin (30), isoquercitrin (31), acaciin (33), kaempferol 3-O-rutinoside (35), rutin (37), and pectolinarin (38) were obtained from Extrasynthese (Genay, France); caffeic acid (2) and neochlorogenic acid (3) were supplied by Phytolab (Vestenbergsgreuth, Germany); and chlorogenic acid (4) was purchased from Sigma-Aldrich (St. Louis, MO, USA). Acetonitrile (hypergrade for LC-MS), formic acid (HPLC-grade), and methanol (analytical-grade) were purchased from Merck (Darmstadt, Germany).…”

Section: Chemicalsmentioning

confidence: 99%

“…In addition, seven diglycosides (33)(34)(35)(36)(37)(38)(39) and four triglycosides (40)(41)(42)(43) were tentatively identified in the studied Primula extracts (Table 2). Compounds 6,9,11,12,13,16,17,22,24,26,30,31,33,35,37,and 38 were identified by comparison with authentic standards.…”

Section: Flavones and Flavonolsmentioning

confidence: 99%

“…The members are widely distributed in the mild climate zone of the northern hemisphere [ 10 ]. The members of the genus Primula are cultivated for ornamental and medicinal purposes in the mild climate zone [ 11 , 12 , 13 ]. The Primula auriculata used in the present study is a rosette plant measuring between 20 and 50 cm height with oblong-lanceolate leaves and bright-purple or violet flowers that mostly bloom during spring [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

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An In-Depth Study on the Metabolite Profile and Biological Properties of Primula auriculata Extracts: A Fascinating Sparkle on the Way from Nature to Functional Applications

et al. 2022

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The biological activity of the aerial part and rhizomes of Primula auriculata were assessed for the first time. The biological activities (antioxidant properties, enzyme inhibition, and AGE inhibition) as well as the phenolic and flavonoid contents of the ethyl acetate, ethanol, hydro-ethanol and water extracts of P. auriculata aerial parts and rhizomes were determined. Cell viability assays and gelatin zymography were also performed for MMP-2/-9 to determine the molecular mechanisms of action. The gene expression for MMPs was described with RT-PCR. The levels of various proteins, including phospho-Nf-κB, BCL-2, BAX, p-53, and cyclin D1 as well as RAGE were measured using Western blot analysis. The hydro-ethanol extract of the aerial part possessed the highest phenolic (56.81 mg GAE/g) and flavonoid (63.92 mg RE/g) contents. In-depth profiling of the specialized metabolites by ultra-high-performance liquid chromatography—high-resolution mass spectrometry (UHPLC-HRMS) allowed for the identification and annotation of 65 compounds, including phenolic acids and glycosides, flavones, flavonols, chalcones, dihydrochalcones, and saponins. The hydro-ethanol extract of the aerial parts (132.65, 180.87, 172.46, and 108.37 mg TE/g, for the DPPH, ABTS, CUPRAC, and FRAP assays, respectively) and the ethanol extract of the rhizomes (415.06, 638.30, 477.77, and 301.02 mg TE/g, for the DPPH, ABTS, CUPRAC, and FRAP assays, respectively) exhibited the highest free radical scavenging and reducing activities. The ethanol and hydro-ethanol extracts of both the P. auriculata aerial part and rhizomes exhibited higher inhibitory activity against acetylcholinesterase, while the hydro-ethanol extracts (1.16 mmol ACAE/g, for both the aerial part and rhizomes extracts) were more active in the inhibition of α-glucosidase. After the treatment of an HT-29 colorectal cancer cell line with the extracts, the apoptosis mechanism was initiated, the integrity of the ECM was remodeled, and cell proliferation was also taken under control. In this way, Primula extracts were shown to be potential drug sources in the treatment of colorectal cancer. They were also detected as natural MMP inhibitors. The findings presented in the present study appraise the bioactivity of P. auriculata, an understudied species. Additional assessment is required to evaluate the cytotoxicity of P. auriculata as well as its activity in ex vivo systems.

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“…Those effects have been observed with plant extracts such as essential oils from mint, lemon balm, coriander, Thymus vulgaris or propolis, and clove oil, or with plant extracts such as caffein, kaempferol, gallic acid, coumarinic acid, quercetin, and garlic [ 32 , 33 , 34 ]. Amongst the essential oils active on Penicillium larvae , that from Thymus vulgaris is one of the most efficient [ 30 , 35 , 39 , 91 , 96 , 108 , 109 , 110 , 111 , 112 , 113 , 123 , 124 , 125 , 126 ].…”

Section: The Role Of Nutritionmentioning

confidence: 99%

Developing Strategies to Help Bee Colony Resilience in Changing Environments

Dequenne¹,

Foy²,

Cani

2022

Animals

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Climate change, loss of plant biodiversity, burdens caused by new pathogens, predators, and toxins due to human disturbance and activity are significant causes of the loss of bee colonies and wild bees. The aim of this review is to highlight some possible strategies that could help develop bee resilience in facing their changing environments. Scientists underline the importance of the links between nutrition, microbiota, and immune and neuroendocrine stress resistance of bees. Nutrition with special care for plant-derived molecules may play a major role in bee colony health. Studies have highlighted the importance of pollen, essential oils, plant resins, and leaves or fungi as sources of fundamental nutrients for the development and longevity of a honeybee colony. The microbiota is also considered as a key factor in bee physiology and a cornerstone between nutrition, metabolism, growth, health, and pathogen resistance. Another stressor is the varroa mite parasite. This parasite is a major concern for beekeepers and needs specific strategies to reduce its severe impact on honeybees. Here we discuss how helping bees to thrive, especially through changing environments, is of great concern for beekeepers and scientists.

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Ethnobotanical and antibacterial study of Primula plants traditionally used in the indigenous communities of Western Himalaya, Pakistan

Cited by 12 publications

References 37 publications

Medicinal plants used against gynecological disorders by the local inhabitants of District Budgam, Kashmir Himalaya

Medicinal plants used against gynecological disorders by the local inhabitants of District Budgam, Kashmir Himalaya

An In-Depth Study on the Metabolite Profile and Biological Properties of Primula auriculata Extracts: A Fascinating Sparkle on the Way from Nature to Functional Applications

Developing Strategies to Help Bee Colony Resilience in Changing Environments

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