Ethnicity-Stratified Analysis of the Association between TNF-α Genetic Polymorphisms and Acute Kidney Injury: A Systematic Review and Meta-Analysis

Abstract

Background. Several studies have reported conflicting findings regarding the association between tumor necrosis factor-alpha (TNF-α) genetic polymorphisms and acute kidney injury (AKI). Therefore, we performed this meta-analysis to further investigate whether TNF-α variants are related to AKI susceptibility. Methods. A comprehensive search of observational studies on the association of TNF-α polymorphism with AKI susceptibility was conducted in the PubMed, Cochrane, and Embase databases through February 10, 2020. Pooled odds ratios (ORs) and 95% corresponding confidence intervals (95% CIs) were analyzed to evaluate the strength of the relationship. Results. A total of 8 studies involving 6694 patients (2559 cases and 4135 controls) were included. Pooled analysis showed a trend of increased risk between the TNF-α rs1800629 variant and AKI (A vs. G: OR 95 % CI = 1.33 0.98 ‐ 1.81 ) among the overall population. Ethnicity-stratified analysis indicated that the TNF-α rs1800629 variant was a risk factor for Asians ( OR 95 % CI = 1.93 1.59 ‐ 2.35 ) while it is not for Caucasians ( OR 95 % CI = 1.04 0.91 ‐ 1.20 ). Additionally, we also found that TNF-α rs1799964 polymorphism was observed to have a significant relationship with AKI risk in Asian patients (C vs. T, OR 95 % CI = 1.26 1.11 ‐ 1.43 ). Conclusions. The TNF rs1800629 polymorphism exhibited a trend toward AKI susceptibility with ethnic differences. The relationship was found to be significant among the Asian population, but not among those of Caucasian origin. Additionally, the TNF-α rs1799964 polymorphism was also related to a significantly increased risk of AKI in Asians.

Acute Kidney Injury During Extracorporeal Membrane Oxygenation: VA ECMO Versus VV ECMO

“…A recently published study has declared that one tumor necrosis factor-α (TNF-α) single nucleotide polymorphisms (SNPs)—rs1800629 polymorphism exhibited a trend toward AKI susceptibility with ethnic differences. 51 Continued studies are recommended to focus on ECMO across different ethnicities. The timing of onset of AKI by any definition is indeed difficult to establish, which is why some studies consider that the three traditional definitions are limited and insufficiently accurate to effectively define ECMO-related AKI.…”

Perioperative acute kidney injury: impact and recent update

“…Early use of risk stratification algorithms and potentially, machine-learning models [115,116], factoring in new AKI biomarkers, may help improve perioperative outcomes. More AKI studies are needed addressing pediatric patients and genetic risk factors [117] and clarifying the utility of GDFT.…”

The Association of Renal Function and Plasma Metals Modified by EGFR and TNF-α Gene Polymorphisms in Metal Industrial Workers and General Population

“…This finding was in line with most previous studies. A systematic review and meta-analysis showed that rs1800629 GA and AA genotypes had a higher trend of AKI in Asians [14]. The homozygous AA genotype was found to have a relationship with CRF and ESRD [15], and A allele had a higher risk of acute rejection in first kidney transplant subjects [36].…”

“…The renal actions of TNF-α include the regulation of hemodynamic and excretory function in the kidney, by inducing renal vasoconstriction and hypofiltration [12,13]. Some studies have demonstrated that TNF-α gene polymorphisms are associated with acute kidney injury (AKI), chronic renal failure (CRF), and ESRD [14,15]. Nevertheless, the relationship between metal-related renal function change and TNF-α gene polymorphisms has not been published.…”