Ethnicity-related differences in tumor immunity: a new possible explanation for gastric cancer prognostic variability?

Marrelli, Daniele; Połom, Karol; Roviello, Franco

doi:10.21037/tgh.2016.03.03

Cited by 6 publications

(5 citation statements)

References 21 publications

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“…Generalisability of this trial’s results is challenging due to small sample size. Furthermore, this study did not include diverse ethnicities; given that GC is far more prevalent among Asian populations [1] and that there may be ethnic differences in the pathology of GC [17, 18], this study cannot inform whether zolbetuximab may exhibit different levels of activity across different ethnicities. Patients enrolled in this study had moderate to strong CLDN18.2 expression.…”

Section: Discussionmentioning

confidence: 99%

A multicentre, phase IIa study of zolbetuximab as a single agent in patients with recurrent or refractory advanced adenocarcinoma of the stomach or lower oesophagus: the MONO study

Türeci¹,

et al. 2019

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BackgroundClaudin 18.2 (CLDN18.2) is physiologically confined to gastric mucosa tight junctions; however, upon malignant transformation, perturbations in cell polarity lead to CLDN18.2 epitopes being exposed on the cancer cell surface. The first-in-class monoclonal antibody, zolbetuximab (formerly known as IMAB362), binds to CLDN18.2 and can induce immune-mediated lysis of CLDN18.2-positive cells.Patients and methodsPatients with advanced gastric, gastro-oesophageal junction (GEJ) or oesophageal adenocarcinomas with moderate-to-strong CLDN18.2 expression in ≥50% of tumour cells received zolbetuximab intravenously every 2 weeks for five planned infusions. At least three patients were enrolled in two sequential cohorts (cohort 1300 mg/m2; cohort 2600 mg/m2); additional patients were enrolled into a dose-expansion cohort (cohort 3600 mg/m2). The primary end point was the objective response rate [ORR: complete and partial response (PR)]; secondary end points included clinical benefit [ORR+stable disease (SD)], progression-free survival, safety/tolerability, and zolbetuximab pharmacokinetic profile.ResultsFrom September 2010 to September 2012, 54 patients were enrolled (cohort 1, n = 4; cohort 2, n = 6; cohort 3, n = 44). Three patients in cohort 1 and 25 patients in cohorts 2/3 received at least 5 infusions. Antitumour activity data were available for 43 patients, of whom 4 achieved PR (ORR 9%) and 6 (14%) had SD for a clinical benefit rate of 23%. In a subgroup of patients with moderate-to-high CLDN18.2 expression in ≥70% of tumour cells, ORR was 14% (n = 4/29). Treatment-related adverse events occurred in 81.5% (n = 44/54) patients; nausea (61%), vomiting (50%), and fatigue (22%) were the most frequent.ConclusionsZolbetuximab monotherapy was well tolerated and exhibited antitumour activity in patients with CLDN18.2-positive advanced gastric or GEJ adenocarcinomas, with response rates similar to those reported for single-agent targeted agents in gastric/GEJ cancer trials.ClinicalTrials.gov numberNCT01197885.

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Section: Discussionmentioning

confidence: 99%

A multicentre, phase IIa study of zolbetuximab as a single agent in patients with recurrent or refractory advanced adenocarcinoma of the stomach or lower oesophagus: the MONO study

Türeci¹,

et al. 2019

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“…An observational retrospective study in France proposed an association between antidepressants and COVID-19 severity [15]. Considering the non-negligible variations among the immune systems of different ethnicities [16] and the diversity of coronavirus subtypes across continents, this study aimed to provide evidence of the association between the use of antidepressants and the severity of COVID-19 in Asian patients.…”

Section: Covid-19 Prognosis In Association With Antidepressant Usementioning

confidence: 99%

COVID-19 Prognosis in Association with Antidepressant Use

Min

Kim

et al. 2022

Pharmacopsychiatry

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Introduction Various subtypes of severe acute respiratory syndrome coronavirus 2 and variations among immune systems in different ethnicities need to be considered to understand the outcomes of coronavirus disease 2019 (COVID-19). This study aimed to provide evidence for the association between the use of antidepressants and the severity of COVID-19. Methods We used the National Health Information Data-COVID database. Patients with one or more prescriptions of any antidepressant were selected as the exposure group. Detailed analyses were performed to determine the type of medication associated with the prognosis. Results The use of selective serotonin reuptake inhibitors (SSRIs) was associated with a lower risk of severe outcomes of COVID-19, whereas the use of tricyclic antidepressants (TCAs) increased the risk of poor prognosis of COVID-19. Detailed analyses showed that escitalopram was significantly associated with better clinical outcomes, and nortriptyline was linked to more severe COVID-19 outcomes. Conclusion This study revealed an association between antidepressants and COVID-19 prognosis. SSRIs were significantly associated with a lower risk of severe outcomes, whereas TCAs were related to the poor prognosis of COVID-19.

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“…In particular, some studies reported that with the implementation of lymphadenectomy procedures with time, a progressive reduction of locoregional recurrences has been observed (26). However, it should be emphasized that when comparing long-term results from Eastern and Western series, a significant better outcome at the same stage is observed in the former, suggesting potential biological differences related to the tumor, to the ethnicity or to the immunological system (50)(51)(52)(53)(54). When analysing long-term results in Western large series, it is evident that survival rates at advanced pT (serosal involvement) and pN stages (N3a and N3b) are unsatisfactory, even when submitting patients to extended lymphadenectomy (55).…”

Section: Long-term Resultsmentioning

confidence: 99%

Lymphadenectomy: state of the art

Marrelli

Franco

Iudici

et al. 2017

Transl. Gastroenterol. Hepatol.

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The extent of lymphadenectomy in gastric cancer (GC) surgery has been for long time a matter of debate. Randomized trials performed in the West reported worse results of D2 dissection, in terms of postoperative complications and long-term survival benefit, than Eastern series and observational studies from specialized Western centers. However, long-term re-evaluation of such trials and in depth-analysis of other experiences demonstrated the potential benefit of D2 in reducing the probability of cancer-related death and the safety of this procedure when avoiding unnecessary spleno-pancreatectomy and in centers with ad adequate surgical volume. Nowadays, the D2 is considered the standard treatment in most guidelines all over the world. More limited procedures (D1, D1 plus) may be adequate in selected cases, and more extended dissections (D2 plus) could be indicated in advanced forms with high risk of metastases to distant nodes, but in specialized centers or in the setting of clinical studies. The integration with neoadjuvant therapies and multimodality approach could offer a chance of cure in groups of patients with poor results when approached with standard treatment.

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Ethnicity-related differences in tumor immunity: a new possible explanation for gastric cancer prognostic variability?

Cited by 6 publications

References 21 publications

A multicentre, phase IIa study of zolbetuximab as a single agent in patients with recurrent or refractory advanced adenocarcinoma of the stomach or lower oesophagus: the MONO study

A multicentre, phase IIa study of zolbetuximab as a single agent in patients with recurrent or refractory advanced adenocarcinoma of the stomach or lower oesophagus: the MONO study

COVID-19 Prognosis in Association with Antidepressant Use

Lymphadenectomy: state of the art

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