Ethnicity Influences Phenotype and Outcomes in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis of Population-based Studies

Shi, Hai; Levy, Alexander N.; Trivedi, Hirsh D.; Chan, Francis K.L.; Ng, Siew C.; Ananthakrishnan, Ashwin N.

doi:10.1016/j.cgh.2017.05.047

Cited by 87 publications

(96 citation statements)

References 49 publications

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“…Among western patients, 30–38% presented with extensive colitis at diagnosis compared to 20–31% in East Asia. In a systematic review, no significant difference in disease extent was found between populations in East and West …”

Section: Clinical Features Of Ibdmentioning

confidence: 94%

“…n mainland China, more than half of CD patients presented with complicated behaviour at diagnosis . A recent meta‐analysis confirmed that a significantly higher proportion of patients presented with complex disease in Asia as compared to western countries (69% vs. 61%) . Perianal involvement is also more common in Asian patients.…”

Section: Clinical Features Of Ibdmentioning

confidence: 99%

“…Up to 39% of all CD patients developed pCD in a recent population‐based cohort study from Korea, the cumulative risk of developing pCD was 40% at five years after diagnosis of CD. A systematic review showed that perianal CD affected nearly one‐fourth of all Asian CD patients …”

Section: Clinical Features Of Ibdmentioning

confidence: 99%

“…16 A recent meta-analysis confirmed that a significantly higher proportion of patients presented with complex disease in Asia as compared to western countries (69% vs. 61%). 40 Perianal involvement is also more common in Asian patients. Up to 39% of all CD patients developed pCD in a recent population-based cohort study from Korea, the cumulative risk of developing pCD was 40% at five years after diagnosis of CD 41 .…”

Section: Clinical Features Of Ibdmentioning

confidence: 99%

“…A systematic review showed that perianal CD affected nearly one-fourth of all Asian CD patients. 40 Disease presentation of ulcerative colitis. In Europe, North America and Australia, 23-34% of UC patients presented with proctitis and 34-51% presented with left-sided colitis.…”

Section: Clinical Features Of Ibdmentioning

confidence: 99%

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The epidemiology of inflammatory bowel disease: East meets west

Mak

Zhao

et al. 2019

J of Gastro and Hepatol

378

291

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The incidence of inflammatory bowel diseases (IBD) in East has risen over the past decade to become a global disease. The increasing number of studies on the incidence and course of IBD in East has enabled us to explore East versus West differences in the epidemiology of IBD which could enhance our understanding of the heterogeneity of the disease and eventually assist in the discovery of novel therapeutic targets and design of preventive strategies. Comparison of population‐based data in East and West reveals that the incidence of IBD has risen rapidly in East while plateauing in West. Furthermore, the clinical presentation and course of IBD differs between East and West with more patients in East presenting with complicated disease. Considering the scarcity of population‐based data from East and the lack of studies with long durations of follow‐up, it remains to be clarified whether these differences reflect true differences in disease presentation. The effects of genetic and environmental risk factors contributing to IBD also differ between Eastern and Western populations. Considering the differential effects of genetic and environmental risk factors in East and West, future studies should seek to discover novel genetic and environmental risk factors which might specifically apply to eastern populations. In this narrative review, we compare the epidemiology of IBD between eastern and western countries by summarizing evidence from population‐based cohort studies in the last ten years. Furthermore, we look at differences in genetic susceptibility and environmental triggers of IBD between East and West.

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Section: Clinical Features Of Ibdmentioning

confidence: 94%

Section: Clinical Features Of Ibdmentioning

confidence: 99%

Section: Clinical Features Of Ibdmentioning

confidence: 99%

Section: Clinical Features Of Ibdmentioning

confidence: 99%

Section: Clinical Features Of Ibdmentioning

confidence: 99%

See 3 more Smart Citations

The epidemiology of inflammatory bowel disease: East meets west

Mak

Zhao

et al. 2019

J of Gastro and Hepatol

378

291

View full text Add to dashboard Cite

show abstract

The epidemiology of inflammatory bowel disease in Asia and Asian immigrants to Western countries

et al. 2022

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Inflammatory bowel disease (IBD), which comprises Crohn's disease and ulcerative colitis, is an idiopathic inflammatory condition of the gastrointestinal tract. The incidence and prevalence of IBD are rapidly increasing worldwide, particularly in newly industrialized regions such as Asia. Although a large medical armamentarium is available for treating this chronic disease, IBD imposes a marked global disease burden. To understand the complex etiopathogenesis of this condition, it is important to consider the rapidly changing trends in its epidemiology in Asia. During the past few decades, the incidence and prevalence of IBD have significantly increased in both Asian countries and Asian immigrants in Western countries. In this review, we aimed to study and update the epidemiology of IBD in diverse Asian regions and among Asian immigrants in North America and Europe. Moreover, we highlighted that this population exhibits a unique disease phenotype, such as male predominance and high frequency of perianal fistula in Crohn's disease. Also, a different disease phenotype including more complicated disease such as perianal complications was noted in Asian Americans and Asian Europeans.

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ATG16L1 rs2241880/T300A increases susceptibility to perianal Crohn's disease: An updated meta‐analysis on inflammatory bowel disease risk and clinical outcomes

Simovic,

Hilmi,

et al. 2023

UEG Journal

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BackgroundATG16L1 plays a fundamental role in the degradative intracellular pathway known as autophagy, being a mediator of inflammation and microbial homeostasis. The variant rs2241880 can diminish these capabilities, potentially contributing to inflammatory bowel disease (IBD) pathogenesis.ObjectivesTo perform an updated meta‐analysis on the association between ATG16L1 rs2241880 and IBD susceptibility by exploring the impact of age, ethnicity, and geography. Moreover, to investigate the association between rs2241880 and clinical features.MethodsLiterature searches up until September 2022 across 7 electronic public databases were performed for all case‐control studies on ATG16L1 rs2241880 and IBD. Pooled odds ratios (ORP) and 95% CI were calculated under the random effects model.ResultsOur analyses included a total of 30,606 IBD patients, comprising 21,270 Crohn's disease (CD) and 9336 ulcerative colitis (UC) patients, and 33,329 controls. ATG16L1 rs2241880 was significantly associated with CD susceptibility, where the A allele was protective (ORP: 0.74, 95% CI: 0.72–0.77, p‐value: <0.001), while the G allele was a risk factor (ORP: 1.23, 95% CI: 1.09–1.39, p‐value: 0.001), depending on the minor allele frequencies observed in this multi‐ancestry study sample. rs2241880 was predominantly relevant in Caucasians from North America and Europe, and in Latin American populations. Importantly, CD patients harbouring the G allele were significantly more predisposed to perianal disease (ORP: 1.21, 95% CI: 1.07–1.38, p‐value: 0.003).ConclusionsATG16L1 rs2241880 (G allele) is a consistent risk factor for IBD in Caucasian cohorts and influences clinical outcomes. As its role in non‐Caucasian populations remains ambiguous, further studies in under‐reported populations are necessary.

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Ethnicity Influences Phenotype and Outcomes in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis of Population-based Studies

Abstract: We demonstrate significant variation in the demographic distribution, familial predisposition, phenotype, and outcomes of IBD between Caucasians, Blacks, Hispanics, and Asians. There is need for further study to understand the biology behind this variation.

Cited by 87 publications

References 49 publications

The epidemiology of inflammatory bowel disease: East meets west

The epidemiology of inflammatory bowel disease: East meets west

The epidemiology of inflammatory bowel disease in Asia and Asian immigrants to Western countries

ATG16L1 rs2241880/T300A increases susceptibility to perianal Crohn's disease: An updated meta‐analysis on inflammatory bowel disease risk and clinical outcomes

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