Ethnicity Differences in the Association of UCP1-3826A/G, UCP2-866G/A and Ala55Val, and UCP3-55C/T Polymorphisms with Type 2 Diabetes Mellitus Susceptibility: An Updated Meta-Analysis

Huang, Rong; Cai, Tingting; Zhou, Yunting; Wang, Yuming; Wang, Huiying; Zheng, Shen; Xia, Wenqing; Liu, Xiaomei; Ding, Bo; Luo, Yong; Yan, Rengna; Li, Huiqin; Wu, Jindan; Ma, Jianhua

doi:10.1155/2021/3482879

Cited by 3 publications

(1 citation statement)

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“…UCP-encoding gene is located on human chromosome 11. [23][24][25] Studies have revealed that UCP2 polymorphism may play a pathological role in diabetes and cancer. [26][27][28] Other studies have found a negative correlation between UCP2 and glucose-stimulated insulin secretion; UCP2 upregulation inhibits insulin secretion and increases the risk of type 2 diabetes.…”

Section: The Underlying Mechanisms Of Diabetes and Thyroid Cancer Her...mentioning

confidence: 99%

Diabetes Mellitus and Thyroid Cancers: Risky Correlation, Underlying Mechanisms and Clinical Prevention

Wu,

Zhang,

Zou

et al. 2024

DMSO

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The incidences of thyroid cancer and diabetes are rapidly increasing worldwide. The relationship between thyroid cancer and diabetes is a popular topic in medicine. Increasing evidence has shown that diabetes increases the risk of thyroid cancer to a certain extent. This mechanism may be related to genetic factors, abnormal thyroid-stimulating hormone secretion, oxidative stress injury, hyperinsulinemia, elevated insulin-like growth factor-1 levels, abnormal secretion of adipocytokines, and increased secretion of inflammatory factors and chemokines. This article reviews the latest research progress on the relationship between thyroid cancer and diabetes, including the association between diabetes and the risk of developing thyroid cancer, its underlying mechanisms, and potential anti-thyroid cancer effects of hypoglycemic drugs. It providing novel strategies for the prevention, treatment, and improving the prognosis of thyroid cancer.

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Section: The Underlying Mechanisms Of Diabetes and Thyroid Cancer Her...mentioning

confidence: 99%

Diabetes Mellitus and Thyroid Cancers: Risky Correlation, Underlying Mechanisms and Clinical Prevention

Wu,

Zhang,

Zou

et al. 2024

DMSO

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Farinaceous and starchy foods in the diet of the indigenous people of the high-latitude and Arctic regions of Russia: tradition and modernity

Козлов

Никитин

2022

VAAE

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The object of the study is the indigenous population of the North and the Arctic of the Russian Federation. The subject of the study is changes in nutrition during transition from the traditional to modernized lifestyle. The purpose of the study is to consider the risk to the health of the northerners in the quantitative and qualitative changes in the consumption of flour and starch-containing products. The consumption of bread products and starch by the population of the northern regions of the Russian Federation in the 19th – 20th centuries and in the 2010s – 2020s was estimated. Estimates of the frequencies of the amylase genes AMY1, AMY2B, AMY2A in the populations that differ in geographic localization and type of management are systemized. In the 20th century, per-capita consumption of bread in Russia decreased from 700 to 260 g/day, among the indeginous northerners — from 300 to 250 g/day. The inclusion of pasta products and potato in the diet of the northerners changed the volume and structure of the consumed carbohydrate foods. The intake of high glycemic load starch increased from 100 to 250 g/day. Replacing the dried crusts with pasta and potato meals eased mastication of food, thus inducing a reflectory rise in serum glucose at ingestion and increasing the risk of developing chronic carbohydrate metabolism disorders. High-latitude populations are distinct in the prevalence of the genotypes that determine low activity of the polysaccharidase enzymes necessary for starch digestion. The ample production of amylase and less prominent blood glucose upswing in response to the consumption of starchy foods are determined by the number of successive copies of the amylase genes on the AMY locus. For the AMY1 gene, a negative correlation was found between the gene copy number and the geographical latitude of the population area (rSp = -0.19), for the AMY2A gene rSp = -0.33 (p < 0.001 in both cases). In addition, in the Arctic groups there is a high frequency of deletions of the AMY2A gene, which also lead to insufficient synthesis of pancreatic amylase. In the European populations, AMY2A deletions occur in 10–11 %; among the Khanty, Mansi, and Selkups — in 28 %; among the indigenous population of Chukotka — in 52 %. Changes in the “Arctic diet” in the 20th century led to a sharp increase in the starch consumption. With the traditional way of life, the northerners did not form adaptations to the nutrient intake of large volumes of starchy foods. In modern conditions, accumulation of nutritional, physiological and genetic factors increases the risk of metabolic disorders related to the consumption of high-starch food.

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Skeletal Muscle Uncoupling Proteins in Mice Models of Obesity

Bombek

Čater

2022

Metabolites

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Obesity and accompanying type 2 diabetes are among major and increasing worldwide problems that occur fundamentally due to excessive energy intake during its expenditure. Endotherms continuously consume a certain amount of energy to maintain core body temperature via thermogenic processes, mainly in brown adipose tissue and skeletal muscle. Skeletal muscle glucose utilization and heat production are significant and directly linked to body glucose homeostasis at rest, and especially during physical activity. However, this glucose balance is impaired in diabetic and obese states in humans and mice, and manifests as glucose resistance and altered muscle cell metabolism. Uncoupling proteins have a significant role in converting electrochemical energy into thermal energy without ATP generation. Different homologs of uncoupling proteins were identified, and their roles were linked to antioxidative activity and boosting glucose and lipid metabolism. From this perspective, uncoupling proteins were studied in correlation to the pathogenesis of diabetes and obesity and their possible treatments. Mice were extensively used as model organisms to study the physiology and pathophysiology of energy homeostasis. However, we should be aware of interstrain differences in mice models of obesity regarding thermogenesis and insulin resistance in skeletal muscles. Therefore, in this review, we gathered up-to-date knowledge on skeletal muscle uncoupling proteins and their effect on insulin sensitivity in mouse models of obesity and diabetes.

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Ethnicity Differences in the Association of UCP1-3826A/G, UCP2-866G/A and Ala55Val, and UCP3-55C/T Polymorphisms with Type 2 Diabetes Mellitus Susceptibility: An Updated Meta-Analysis

Cited by 3 publications

References 64 publications

Diabetes Mellitus and Thyroid Cancers: Risky Correlation, Underlying Mechanisms and Clinical Prevention

Diabetes Mellitus and Thyroid Cancers: Risky Correlation, Underlying Mechanisms and Clinical Prevention

Farinaceous and starchy foods in the diet of the indigenous people of the high-latitude and Arctic regions of Russia: tradition and modernity

Skeletal Muscle Uncoupling Proteins in Mice Models of Obesity

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