Ethnicity Differences and Outcomes for Patients With Autoimmune Hepatitis: A Single Community Center Experience

Sadri, Lilly; Puchakayala, Bharat; Sanivarapu, Raghavendra; Mohanty, Smruti R.

doi:10.14309/00000434-201510001-02098

Cited by 1 publication

(3 citation statements)

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“…First, the trend of black patients having more severe (but not statistically significant) presentations corroborate other studies. [12,14,15,28] Second, we found that 31% (n = 9) of our Latino cohort had cirrhosis at presentation, while a prior cohort from Mexico found that 56% of their patients had cirrhosis at presentation. [29] Latinos have been found to be less likely to achieve remission and have poorer outcomes, which our results do not replicate.…”

Section: Discussionmentioning

confidence: 81%

“…[26,30] Third, bilirubin was the only finding approaching significance in our study, similar to a single-center study from New York, where total bilirubin was significantly higher among black patients with AIH. [15] Prior regional multiethnic AIH cohorts have conflicting results, but generally find a trend towards poorer outcomes in people of color. [31,27,32] Many prior studies have focused on comparing two ethnic groups, with white patients as the reference.…”

Section: Discussionmentioning

confidence: 99%

“…[10–13] Compared to white patients, black patients appear to have a more severe disease course in the setting of AIH. [12,14,15] In addition, the prevalence of AIH may vary by race/ethnicity. In a study from New Zealand the ethnicity-specific prevalence of AIH was higher among whites than Maori, Pacific Islanders, and Asians.…”

Section: Introductionmentioning

confidence: 99%

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Race/ethnicity is an independent risk factor for autoimmune hepatitis among the San Francisco underserved

et al. 2018

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Although autoimmune hepatitis (AIH) is more common in women and affects people of all races/ethnicities, there is currently limited information regarding the relationship between race/ethnicity and AIH, especially in the context of underserved populations. We aim to evaluate the relationship between race/ethnicity and AIH and better characterize its clinical features among different racial groups. We conducted a 15-year retrospective analysis, from January 2002 to June 2017, of patients seen at Zuckerberg San Francisco General Hospital (ZSFG). Sixty-three AIH patients and 2049 non-AIH controls were eligible for the study. The main predictor of interest was race/ethnicity, and the main outcome of interest was AIH diagnosis; other secondary measures recorded include clinical features such as ALT, bilirubin, and biopsy fibrosis at presentation. In a multivariable model adjusting for age and sex, we found that black (OR 9.6, 95% CI 1.8-178), Latino (OR 25.0, 95% CI 5.3-448), and Asian/Pacific Islander (API) (OR 10.8, 95% CI 2.2-196) race/ethnicity were associated with increased odds of an AIH diagnosis compared to the white reference group. Among people of colour with AIH, there were no significant differences in baseline ALT (p = .45), total bilirubin at presentation (p = .06), fibrosis at presentation (p = .74), and hospitalization (p = .27). Race/ethnicity is an independent risk factor for AIH. The clinical features of AIH did not differ significantly among black, Latino, and API patients.

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