Ethnic Variations in Drug Response

Murphy, H.B.M.

doi:10.1177/136346156900600101

Cited by 24 publications

(5 citation statements)

References 9 publications

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“…Culture, therapy and personality Murphy (1969Murphy ( , 1972 argued that not only do individual personality traits play an important role in responses, but also these traits are modified by culture. When culture allows and encourages individuals to be independent, to struggle and take action, there may be a greater readiness to use and hence need medication.…”

Section: Complementary Therapiesmentioning

confidence: 99%

Clinical management of patients across cultures

Bhugra¹,

Bhui²

1997

Adv. psychiatr. treat

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Clinical management of patients across cultures challenges the clinician's familiar tried and tested strategies. The relationship between the patient and the psychiatrist is often examined in isolation from a number of premises which both patient and professional bring to the encounter: previous experience of other cultures, contact with less familiar cultures, past experiences and socioeconomic status are some of the determinant influences. There are a number of ways in which the clinician can facilitate therapeutic effectiveness. However, a trusting relationship must first emerge such that the patient has faith in the treatment recommendations. Special difficulties can arise in the context of pharmacological, social, psychotherapeutic and psychological interventions. Community, out-patient, in-patient and emergency settings each require that consideration be given to the context of the assessment and treatment process, as well as the content and immediate outcome. The clinician must plan the assessment and intervention carefully. The rationale and goals of treatment should be discussed and agreed by participants in the therapeutic interaction. Special groups have unique cultural and historical obstacles to receiving health care. Potential problems are highlighted in this paper and suggestions made for managing conflicts when they arise.

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Section: Complementary Therapiesmentioning

confidence: 99%

Clinical management of patients across cultures

Bhugra¹,

Bhui²

1997

Adv. psychiatr. treat

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“…Ethnicity has been identified by several clinical and survey reports as being an important factor in determining benzodiazepine responses (Kumana, Lauder, Chan, KO, & Lin, 1987;Murphy, 1969;Rosenblat & Tang 1987). As with TCAs, the majority of reports regarding benzodiazepines have been based on Asian/Caucasian comparisons.…”

Section: Benzodiazepines and Asiansmentioning

confidence: 99%

“…As with TCAs, the majority of reports regarding benzodiazepines have been based on Asian/Caucasian comparisons. Murphy (1969) first suggested that as compared with Caucasians, Asians may be more sensitive to the effects of various psychotropics, including anxiolytics. This was supported by recent surveys of the prescription patterns of psychiatrists who regularly treat both Asian and noneAsian patients (Kumana et al, 1987;Rosenblat 6r Tang, 1987).…”

Section: Benzodiazepines and Asiansmentioning

confidence: 99%

Ethnopsychopharmacology and the treatment of PTSD.

Lin¹,

Poland²,

Anderson³

1996

Ethnocultural Aspects of Posttraumatic Stress Disorder: Issues, Research, and Clinical Applications.

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Pharmacotherapy represents an important part of the care of patients suffering from PTSD and related problems and has been the focus of intense research efforts in recent years. As a clear reflection of progress in this regard, a large number of psychotropic agents have become available for the treatment of these conditions, and the majority of PTSD patients benefit from such interventions. These pharmacotherapeutic agents include tricyclic antidepressants, (TCAs), neuroleptics, benzodiazepines, and lithium (Smith, Cartaya, Mendoza, Lesser, & Lin, in press). Recent literature has clearly indicated that ethnicity and culture often exert important influences on the clinical effects of these potent therapeutic agents. These issues are highly relevant for the clinical care of PTSD patients with ethnic minority backgrounds.In this chapter, we first review the principles of how ethnicity may interact with drug metabolism and drug action. Next, the role that ethnicity plays in relation to the specific classes of medications that are commonly used to treat PTSD-antidepressants, neuroleptics, benzodiazepines, and lithium-is covered. Finally, we briefly discuss future research directions and the applicability of this research to clinical practice.

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“…Higher amounts have a negative impact on the client's memory and reduces her ability to benefit from rehabilitation Chou, Doryon, Czobar, and Vulavka (1991). andMurphy (1969), research psychiatrists, have found that some members of different racial groups me tabolize psychotropic medications at different rates. For example, in general, African-American men tend to benefit from lower dosages of medications than white men.…”

mentioning

confidence: 99%

Multiculturalism: Myths and miracles.

Pernell-Arnold¹

1998

Psychiatric Rehabilitation Journal

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Ethnic Variations in Drug Response

Cited by 24 publications

References 9 publications

Clinical management of patients across cultures

Clinical management of patients across cultures

Ethnopsychopharmacology and the treatment of PTSD.

Multiculturalism: Myths and miracles.

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