Ethnic variation of fetal nasal bone length between 11-14 weeks' gestation

Collado, F. Khoury; Bombard, Allan T.; Li, Vuysan; Juliard, Kell; Weiner, Zeev

doi:10.1016/j.ajog.2004.10.414

Cited by 7 publications

(9 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, our mean NBL findings differ negatively at the 11 th , 12 th and 13 rd gestational weeks from some of these studies (12,22,23) and positively from some others (19,23). This difference might be due to ethnical difference (25) as well as interobserver and intraobserver variability in the measurement of length of the nasal bone (11,13,14). Variations may also be due to the quality of the machine as well, however it seems to be difficult to compare all these previous studies in this sense as most had different brand types of sonographic devices (12,(20)(21)(22)(23)(24).…”

Section: Discussioncontrasting

confidence: 54%

Normative values of fetal nasal bone lengths of Turkish singleton pregnancies in the first trimester

Yayla¹,

Ergin²,

Göynümer³

2011

J Turkish German Gynecol Assoc

View full text Add to dashboard Cite

Objective: Evaluation of nasal bone improves the performance of firsttrimester screening for trisomy 21. In this retrospective study we aimed to determine normative values related to the measurement of nasal bone length of the Turkish population during the first trimester ultrasonographic fetal screening. Material and Methods:Medical records of singleton pregnancies, whose first trimester fetal screening was performed between 2004 and 2010, were evaluated retrospectively. Pregnancies with any detected/ suspicious anatomical or genetic fetal anomalies, biochemical abnormalities, increased nuchal translucency measurements, and pregnancies of artificial reproduction techniques were excluded from data analyses. Mean±standard deviation, median and percentile values of the length of nasal bone were calculated separately for 11 [0][1][2][3][4][5][6] , 12 0-6 and 13 0-6 gestational weeksResults: Nasal bone could be visualized in 99.6% of the included 1762 singleton pregnancies. In 16.5% of the cases nasal bones were only noted as present or absent. Mean maternal age was 29.67±4.50 years and mean gestational age was 12.54±0.61 weeks. Median values of nasal bone lengths were 1.7, 1.9, and 2.2 mm for 11 [0][1][2][3][4][5][6] , 12 0-6 and 13 0-6 gestational weeks respectively. Nasal bone length (NBL) increased linearly with advancing gestational age and CRL. NBL (mm) Conclusion:The present study presents normative values of nasal bone in the first trimester screening of normal singleton pregnancies of Turkish population. Nasal bone length increases with advancing gestational age and CRL. (J Turkish-German Gynecol Assoc 2011; 12: 225-8) Key words: Screening, nasal bone, pregnancy, ultrasonography, fetus Received: 11 August, 2011 Accepted: 26 September, 2011 Amaç: Birinci tirmester trizomi 21 taramas nda nazal kemik de erlendirmesi performans artt rmaktad r. Bu retrospektif çal mada Türk popülasyonundaki tekil gebeliklerde birinci trimester fetal nazal kemik ölçümlerinin gebelik haftalar na göre persentil da l mlar n n saptanmas amaçland .

show abstract

Section: Discussioncontrasting

confidence: 54%

Normative values of fetal nasal bone lengths of Turkish singleton pregnancies in the first trimester

Yayla¹,

Ergin²,

Göynümer³

2011

J Turkish German Gynecol Assoc

View full text Add to dashboard Cite

show abstract

“…In a pioneering study, . Therefore, the ethnic factor should be taken into consideration in the utilization of the nasal bone length in the screening for trisomy 21 in the first trimester of gestation (7) . There are several studies determining reference values for fetal nasal bone length between the 11th-14th gestational weeks in different populations (8,9) , as well as in different ethnic groups (5) .…”

Section: Introductionmentioning

confidence: 99%

Medida do comprimento do osso nasal entre 11 e 15 semanas de gestação em uma população brasileira: estudo preliminar

Cossi¹,

Júnior

Bussamra

et al. 2008

Radiol Bras

View full text Add to dashboard Cite

Fetal nasal bone length in the period between 11 and 15 gestational week Cicero et al.(3) have evidenced that the nasal bone was absent in 43 of 59 (73%) fetuses with trisomy 21, and in three of 603 (0.5%) chromosomically normal fetuses between the 11th and 14th gestational weeks. In a recent study, the addition of the nasal bone evaluation to the measurement of nuchal translucency (NT) and maternal biochemical serum screening maintained the rate of detection of trisomy 21 at 90%, however reduced the false positive rates from 5% to 2.5% (4) . It is important to note that the visualization and/or measurement of the nasal bone length between the 11th and 14th gestaCossi PS, Araujo Júnior E, Bussamra LCS, Guimarães Filho HA, Nardozza LMM, Moron AF. Measurement of fetal nasal bone length in the period between 11 and 15 gestational weeks in a Brazilian population: a preliminary study. Radiol Bras. 2008;41(3):155-158.

show abstract

“…3 To define NB hypoplasia, nomograms are set in Caucasian, African-American, Korean and Chinese populations. [4][5][6][7] An objective approach of measurement of NB length according to gestational age and setting nomogram helps to ascertain NB hypoplasia.…”

Section: Introductionmentioning

confidence: 99%

“…2 Ethnic differences in NB length have been reported. 3 To define NB hypoplasia, nomograms are set in Caucasian, African-American, Korean and Chinese populations.…”

Section: Introductionmentioning

confidence: 99%

Nomogram of nasal bone length at 11-14 week of gestation in Indian women and their follow up till delivery

Prabha

Kumar

2016

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

INTRODUCTIONThe first trimester screening in pregnancy is very effective in diagnosing chromosomal abnormalities and assessment of nasal bone is one of the effective secondary factors. Maternal age, Nuchal translucency (NT) and free β-hCG and PAPP-A (combined test) is found to have 85-95% detection rate for fetal aneuploidy with a false-positive rate of 5% whereas combined test along with nasal bone (NB) or tricuspid flow or ductus venosus flow has detection rate of 93-96% and false positive rate of 2.5% for euploid, 60% of trisomy 21, 53% for trisomy 18 and 45% for trisomy 13.1 Hence, NB absence or hypolplasia is a promising component of screening test.2 Ethnic differences in NB length have been reported. 3 To define NB hypoplasia, nomograms are set in Caucasian, African-American, Korean and Chinese populations. [4][5][6][7] An objective approach of measurement of NB length according to gestational age and setting nomogram helps to ascertain NB hypoplasia. This can also be used for Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT Background:The measurement of nasal bone length (NBL) according to gestational age and setting nomogram helps to ascertain NB hypoplasia. This can be used for early detection of trisomy 21 and other chromosomal abnormalities in low risk population. The objective of the study was to obtain nomogram of fetal nasal bone length at 11-14 weeks gestation with known prognosis pregnancies. Methods: A single centre, prospective crosses sectional study. Nasal bone length of 323 choromosomal and structural normal fetuses at 11-14 weeks gestation were measured by transabdominal ultrasonography, prospectively. The correlation between nasal bone and other biometric parameters was assessed by regression analysis and average±SD of nasal bone lengths were measured.

show abstract

Ethnic variation of fetal nasal bone length between 11-14 weeks' gestation

Cited by 7 publications

References 0 publications

Normative values of fetal nasal bone lengths of Turkish singleton pregnancies in the first trimester

Normative values of fetal nasal bone lengths of Turkish singleton pregnancies in the first trimester

Medida do comprimento do osso nasal entre 11 e 15 semanas de gestação em uma população brasileira: estudo preliminar

Nomogram of nasal bone length at 11-14 week of gestation in Indian women and their follow up till delivery

Contact Info

Product

Resources

About