1981
DOI: 10.1073/pnas.78.9.5768
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Ethnic variation in Hpa 1 endonuclease cleavage patterns of human mitochondrial DNA.

Abstract: The mtDNAs of 235 individuals from five ethnic groups were analyzed for restriction site variation by digestion with restriction endonuclease Hpa I, Southern transfer, and hybridization with 32P-labeled human mtDNA. Six different cleavage patterns (morphs) were found, all of which could be related to each other by single nucleotide substitutions. Differences were found in the frequency of these morphs among the populations.

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Cited by 113 publications
(80 citation statements)
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“…Morph 1 has been detected in Africans (Bantu) and Orientals (Denaro et al, 1981). been detected only in Orientals (Denaro et al, 1981). The variations in mtDNAs detected by HpaI were explained by HineII digestion patterns in the present study.…”
Section: Cleavage Patternssupporting
confidence: 51%
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“…Morph 1 has been detected in Africans (Bantu) and Orientals (Denaro et al, 1981). been detected only in Orientals (Denaro et al, 1981). The variations in mtDNAs detected by HpaI were explained by HineII digestion patterns in the present study.…”
Section: Cleavage Patternssupporting
confidence: 51%
“…HpaI: Three distinct morphs, morph 1, 2 and 4, which have already been reported (Brown, 1980;Denaro et al, 1981), were detected when mtDNAs of the Ainu and the Non-Ainu Japanese were digested with HpaI (Fig. 4).…”
Section: Cleavage Patternsmentioning
confidence: 60%
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“…Thus, anthropological science must be synthetically as well as analytical because it studies man in his entirety. Genetic data have shown a surprisingly small amount of genetic variation, noted throughout all present human populations (e.g., Denaro et al 1981;Hammer et al, 1995;Knight et al, 1996). These important genetic data support strongly the "single origin" model adding that this single origin was relatively recent.…”
supporting
confidence: 58%