Ethnic origin and increased risk for schizophrenia in immigrants to countries of recent and longstanding immigration

Dealberto, Marie-José

doi:10.1111/j.1600-0447.2009.01535.x

Cited by 75 publications

(47 citation statements)

References 118 publications

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“…These ecological findings suggest sun exposure and therefore vitamin D is a risk factor for psychotic disorders. These findings are consistent with the increased rates of psychotic disorders observed in Black ethnic migrant groups (Cantor-Graae and Selten, 2005;Dealberto, 2010) partially due to darker skin pigments being less able to absorb Ultraviolet B (UVB) radiation, higher rates in urban compared with rural areas and the high ratio of patients diagnosed being born in winter months (McGrath, 1999;McGrath et al, 2004).…”

Section: Introductionsupporting

confidence: 63%

Correlates of vitamin D in psychotic disorders: A comprehensive systematic review

Adamson

Lally

Gaughran

et al. 2017

Psychiatry Research

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(199/ 200)People with psychosis have high prevalence of low vitamin D levels but the correlates and relevance of this deficiency are unclear. A systematic search of major databases from inception to 03/2016 was undertaken investigating correlates of vitamin D in people with psychosis. Data was summarised with a best evidence synthesis. Across 23 included studies (n=1,770 psychosis, n= 8,171 controls) a mean difference in vitamin D levels between both groups of -11.14 ng/ml 0.59 was found.

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Section: Introductionsupporting

confidence: 63%

Correlates of vitamin D in psychotic disorders: A comprehensive systematic review

Adamson

Lally

Gaughran

et al. 2017

Psychiatry Research

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“…Thus it may be the case that to speak of « immigration and mental health » without taking into consideration the receiving country may be overly reductionistic. There is both conceptual (12) and empirical evidence that suggests that sociopolitical context has an impact on immigration processes and associated mental health (13,14). To that end, expanding the locale of epidemiological studies on migration and mental health could be of interest, particularly given that the bulk of studies have been carried out in countries with a long history of migration, 4 of which are English speaking (the US, the UK, Canada and Australia).…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of psychiatric morbidity among migrants compared to native born population in Spain: a controlled study

Qureshi

Collazos

Sobradiel

et al. 2013

General Hospital Psychiatry

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Epidemiology of diagnostic-level psychiatric symptoms in primary care: A comparison of immigrants to native Spaniards. Abstract ObjectiveThe aim of this paper is to explore the prevalence of psychiatric morbidity in different immigrant groups in Spain. In keeping with prior studies carried out in Europe, it is expected that the immigrant population will have elevated levels of psychopathology, with some variation across immigrant groups. Method ResultsNo differences in psychiatric morbidity were found (native born 30.9%, population vs. immigrants 29.6%, OR= .942, CI=.806-1.100) when comparing immigrants to native born Spaniards. Relative to Spaniards (30.9%), Latin American immigrants had significantly higher levels of psychopathology (36.8%), Sub-Saharan Africans (24.4%) and Asians (16%) had significantly lower levels, and Eastern Europeans (31.4%) and North Africans (26.8%) showed no significant difference. ConclusionsThe hypotheses were only partially supported. Although overall immigrants did not differ from the native born population, when analyzed by geographic origin, only Latin Americans had higher levels of psychopathology. It is concluded that multiple factors need to be taken into consideration when studying the mental health of immigrants given that different immigrant groups have different levels of psychopathology.

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“…Schizophrenia is a complex syndromic disease 29 with geographically varying prevalence 30 and characterized by a markedly elevated prevalence among first and second generation immigrants 31,32 , particularly among persons with dark skin moving to Nordic lattitudes 33 . These not peer-reviewed) is the author/funder.…”

Section: Discussionmentioning

confidence: 99%

Mitochondrial DNA SNPs associated with Schizophrenia exhibit Highly Variable Inter-allelic Haplogroup Affiliation and Nuclear Genogeographic Affinity: Bi-Genomic Linkage Disequilibrium raises Major Concerns for Link to Disease

Hagen

Gonçalves

Hedley

et al. 2017

Preprint

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Mitochondria play a significant role in human diseases. However, disease associations with mitochondrial DNA (mtDNA) SNPs have proven difficult to replicate. A reanalysis of eight schizophrenia-associated mtDNA SNPs, in 23,743 normal Danes and 2,538 schizophrenia patients, revealed marked inter-allelic differences in haplogroup affiliation and nuclear ancestry, genogeophraphic affinity (GGA). This bi-genomic linkage disequilibrium (2GLD) could entail population stratification. Only two mitochondrial SNPs, m.15043A and m.15218G, were significantly associated with schizophrenia. However, these associations disappeared when corrected for haplogroup affiliation. The extensive 2GLD documented is a major concern when interpreting historic as well as designing future mtDNA association studies.not peer-reviewed) is the author/funder. All rights reserved. No reuse allowed without permission.The copyright holder for this preprint (which was . http://dx.doi.org/10.1101/149070 doi: bioRxiv preprint first posted online 3 Genetic variants in mitochondrial DNA (mtDNA) -and in nuclear genes coding for mitochondrial function -have been associated with disease 1-3 . More than 300 variants 4,5 in mtDNA and genes involved in mitochondrial function 6 have been reported to cause mitochondrial disease which is clinically characterised by complex metabolic, neurological, muscular and psychiatric symptoms 7,8 .SNPs in mtDNA and mitochondrial haplogroups (mtDNA hgs), which are evolutionarily fixed SNP sets with a characteristic geographical distribution, have been proposed as potential disease modifiers 8 . This has been reported in neurological degenerative diseases such as Alzheimer's disease 9-12 and Parkinson's disease 12-14 , metabolic diseases and cancers 15 , as well as psychiatric diseases, notably schizophrenia (SZ) and bipolar disease [16][17][18] .Association studies of mtDNA variants and disease have been difficult to replicate 8 . However, the definition of a methodological paradigm for association studies with mtDNA variants 19 implicitly assumes that mtDNA variants are independent of the nuclear genome. In a recent Danish study on mtDNA haplogroups and their nuclear ancestry or nuclear genogeographical affinity (GGA), we demonstrated a marked difference in nuclear ancestry between individual haplogroups 20 . This means that mtDNA hgs entail population stratification also at the level of gDNA. The effect of such a stratification on disease association, will depend on the admixture structure of the particular population, the population history, epidemiology and genetic epidemiology of the disease, as well as the number of persons included in the study. The extensive fine-scale heterogeneity of gDNA and significant admixture documented in the UK 21 and Europe 22 further increase the risk of spurious false positive associations, if the mtDNA/gDNA interaction is not corrected phenomenon for in association studies.not peer-reviewed) is the author/funder. All rights reserved. No reuse allowed without permission.The co...

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Ethnic origin and increased risk for schizophrenia in immigrants to countries of recent and longstanding immigration

Cited by 75 publications

References 118 publications

Correlates of vitamin D in psychotic disorders: A comprehensive systematic review

Correlates of vitamin D in psychotic disorders: A comprehensive systematic review

Epidemiology of psychiatric morbidity among migrants compared to native born population in Spain: a controlled study

Mitochondrial DNA SNPs associated with Schizophrenia exhibit Highly Variable Inter-allelic Haplogroup Affiliation and Nuclear Genogeographic Affinity: Bi-Genomic Linkage Disequilibrium raises Major Concerns for Link to Disease

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