Ethnic Influences on Neurovascular Coupling

Hao, Qing; Wong, Ka Sing; Lin, Wen Hua; Leung, Thomas W.; Kaps, Manfred; Rosengarten, Bernhard

doi:10.1161/strokeaha.109.566752

Cited by 12 publications

(9 citation statements)

References 8 publications

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“…Our fTCD findings are therefore indicative of a disturbed neurovascular coupling in the visual cortex of FD patients. The decreased rate time and gain reflect a lower hemodynamic response to visual activation tasks [25,26]. As data from animal experiments suggest that this response might be related to a deficit in the nitric oxide system [27], our results fit into the hypothesis of an impaired functioning of the endothelial nitric oxide system in FD [28].…”

Section: Discussionsupporting

confidence: 71%

Functional Transcranial Doppler: Presymptomatic Changes in Fabry Disease

Azevedo

Mendes²,

Seixas³

et al. 2012

Eur Neurol

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Background and Aim: Cerebrovascular disease may progress asymptomatically in the early stages of Fabry disease (FD). Our aim was to test whether functional transcranial Doppler (fTCD) could provide useful data in the evaluation of these presymptomatic FD patients. Methods: A cohort of 12 adult FD patients from families with the classical phenotype of the disease was evaluated with fTCD in the posterior cerebral artery. Results: Compared to healthy controls, resting blood velocities were significantly lower in the FD cohort (p = 0.032 for systolic, p = 0.021 for diastolic). FTCD suggested a disturbed neurovascular coupling in the visual cortex of FD patients, with lower gain (p = 0.007) and rate time (p = 0.019). Men had a significantly higher attenuation (p = 0.013) and lower natural frequency (p = 0.046) than the heterozygous women. Conclusion: These data are the first to suggest that patients with FD may develop cortical vascular dysfunction in the territory of the posterior circulation, early in the natural history of the disease. If the present findings are confirmed in larger, prospective studies, fTCD will be useful for assessing stroke risk in as yet asymptomatic FD patients, improving preventive therapeutic management.

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Section: Discussionsupporting

confidence: 71%

Functional Transcranial Doppler: Presymptomatic Changes in Fabry Disease

Azevedo

Mendes²,

Seixas³

et al. 2012

Eur Neurol

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“…Since differences in CBF and its control mechanisms between European and South American populations have not been previously reported, it is difficult to assess consistency with other studies in the literature. A previous TCD study of healthy young participants ( n = 20) in Germany and Hong Kong described no CBFv differences in the posterior cerebral arteries at rest and during cerebral activation [ 24 ]. Nevertheless, slower initial haemodynamic responses to visual activation paradigms were described in the Asian group that may be related to deficits in the nitric oxide system.…”

Section: Discussionmentioning

confidence: 99%

Pooling data from different populations: should there be regional differences in cerebral haemodynamics?

et al. 2018

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BackgroundThough genetic and environmental determinants of systemic haemodynamic have been reported, surprisingly little is known about their influences on cerebral haemodynamics. We assessed the potential geographical effect on cerebral haemodynamics by comparing the individual differences in cerebral blood flow velocity (CBFv), vasomotor tone (critical closing pressure- CrCP), vascular bed resistance (resistance-area product- RAP) and cerebral autoregulation (CA) mechanism on healthy subjects and acute ischaemic stroke (AIS) patients from two countries.MethodsParticipants were pooled from databases in Leicester, United Kingdom (LEI) and São Paulo, Brazil (SP) research centres. Stroke patients admitted within 48 h of ischaemic stroke onset, as well as age- and sex-matched controls were enrolled. Beat-to-beat blood pressure (BP) and bilateral mean CBFv were recorded during 5 min baseline. CrCP and RAP were calculated. CA was quantified using transfer function analysis (TFA) of spontaneous oscillations in arterial BP and mean CBFv, and the derived autoregulatory index (ARI).ResultsA total of 100 participants (50 LEI and 50 SP) were recruited. No geographical differences were found. Both LEI and SP AIS participants showed lower values of CA compared to controls. Moreover, the affected hemisphere presented lower resting CBFv and higher RAP compared to the unaffected hemisphere in both populations.ConclusionsImpairments of cerebral haemodynamics, demonstrated by several key parameters, was observed following AIS compared to controls irrespective of geographical region. These initial results should encourage further research on cerebral haemodynamic research with larger cohorts combining different populations.

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“…Demarin & Rundek (1992) investigated cerebral VMR in healthy subjects using fTCD device and acetazolamide as a vasoactive stimulus in healthy subjects and established a dynamic component of vasoreactive response in MCA. Furthermore, the results of the fTCD study evaluating a haemodynamic response in both PCAs using a visual stimulation and measuring the rate time as defined as the initial speed of flow velocity adaptation, carried out by Hao et al. (2010), revealed ethnic influences on neurovascular coupling that was significantly lower in Asians than in healthy Caucasians.…”

Section: Discussionmentioning

confidence: 99%

Prolonged mean reaction time in posterior cerebral artery during visual stimulation in patients with severe carotid stenosis

Bedeković

Lovrenčić-Huzjan

Puretić

et al. 2011

Clinical Physiology and Functional Imaging

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While the mean increase in flow velocities in posterior cerebral artery (PCA) as a response to visual stimuli is well documented, the data on the reaction time as a measurement of the vasomotor response of the posterior part of the circle of Willis are still sparse. The aim was to assess the visual evoked response in PCA during white light stimulation by means of functional transcranial doppler in patients with severe internal carotid artery (ICA) stenosis, to introduce a real-time haemodynamic changes as a measurement of the effect of severe carotid disease on the posterior circulation. The measurements were taken in 49 right-handed patients with severe ICA stenosis or occlusion and 30 healthy volunteers, simultaneously in left and right PCA using 2-MHz probes, successively in the dark and during the white light stimulation, during three consecutive repetitive periods of 1 min each. Mean values of mean blood flow velocities (MBFV) and mean reaction time (MRT) with and without visual stimuli were analysed. Linear regression analysis showed no statistically significant correlation between the age, MBFV and a degree of left and right carotid stenosis, and MRT in left and right PCA either in the group of healthy subjects or in the group of patients with severe carotid stenosis, in both test conditions. MRT could be an indicator of compromised cerebral circulation in the presence of haemodynamic significant carotid stenosis as well as an additional and independent haemodynamic parameter of the cerebral visual evoked response.

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Ethnic Influences on Neurovascular Coupling

Cited by 12 publications

References 8 publications

Functional Transcranial Doppler: Presymptomatic Changes in Fabry Disease

Functional Transcranial Doppler: Presymptomatic Changes in Fabry Disease

Pooling data from different populations: should there be regional differences in cerebral haemodynamics?

Prolonged mean reaction time in posterior cerebral artery during visual stimulation in patients with severe carotid stenosis

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