2012
DOI: 10.1182/blood.v120.21.757.757
|View full text |Cite
|
Sign up to set email alerts
|

Ethnic Disparities in Chronic Lymphocytic Leukemia Survival: A SEER Database Review

Abstract: 757 Background: Chronic lymphocytic leukemia (CLL) is the most common leukemia seen in adults. Previous population-based research in CLL has not represented the current ethnic makeup and diversity within the US population. We undertook a large Surveillance Epidemiology and End Results (SEER) based analysis to assess disparities in outcome among different ethnic subgroups of CLL patients, so that therapeutic resources can be utilized effectively. … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3

Citation Types

0
4
0

Year Published

2014
2014
2024
2024

Publication Types

Select...
4
1

Relationship

0
5

Authors

Journals

citations
Cited by 5 publications
(4 citation statements)
references
References 0 publications
0
4
0
Order By: Relevance
“…Notably, gender variations have a significant impact on cancer, resulting in incidence rates being up to 20% greater and mortality rates up to 40% higher among males [ 14 ]. A collection of previous studies has clarified that the notable difference between sexes is related to many factors, namely awareness, treatment, healthcare use, disease control rate, time of diagnosis, occupational exposure, and differences in overall survival [ 15 17 ]. In terms of leukemia, the male population exhibited higher rates of incidence and mortality compared to females, highlighting the impact of biologic and epidemiologic factors [ 1 , 4 , 10 , 11 , 18 , 19 ].…”
Section: Introductionmentioning
confidence: 99%
“…Notably, gender variations have a significant impact on cancer, resulting in incidence rates being up to 20% greater and mortality rates up to 40% higher among males [ 14 ]. A collection of previous studies has clarified that the notable difference between sexes is related to many factors, namely awareness, treatment, healthcare use, disease control rate, time of diagnosis, occupational exposure, and differences in overall survival [ 15 17 ]. In terms of leukemia, the male population exhibited higher rates of incidence and mortality compared to females, highlighting the impact of biologic and epidemiologic factors [ 1 , 4 , 10 , 11 , 18 , 19 ].…”
Section: Introductionmentioning
confidence: 99%
“…(1,2) This amounts to a low prevalence of CLL in non-White populations, who represent between 11-13% of CLL patients. (3,4) While the etiology underlying the decreased incidence of CLL in racial and ethnic minority populations is not fully understood, it is hypothesized to be related to genetic rather than environmental factors. (5)(6)(7)(8) Due to low incidence of CLL in non-White persons, there are minimal data available to help understand how the disease course of CLL may differ between racial and ethnic groups.…”
Section: Introductionmentioning
confidence: 99%
“…Furthermore, population and multi-institution studies have raised concerns that racial and ethnic minority patients with CLL have inferior survival as compared to White patients. (3,(9)(10)(11)(12)(13) The largest study to date used the SEER database to identify 2 059 Black patients from a total population of 30 622 CLL patients, diagnosed between 1992-2007. In this study, Black patients presented with CLL at a younger age than White patients (mean 67 years vs 70 years) and had significantly lower rates of 5-year relative survival than White patients, at 63.9 vs 77.1%, respectively.…”
Section: Introductionmentioning
confidence: 99%
“…Furthermore, population and multi-institution studies have raised concerns that racial and ethnic minority patients with CLL have inferior survival as compared to White patients. [1][2][3][4][5] However, since these studies were published, the management of CLL has dramatically improved. With the approval of Ibrutinib, the first-in-class Bruton's tyrosine kinase inhibitor, in 2014, the treatment landscape has shifted to predominately novel targeted therapies.…”
mentioning
confidence: 99%