Ethnic differences in the association of factor V Leiden mutation and the C677T methylenetetrahydrofolate reductase gene polymorphism with preeclampsia

Prasmusinto, Damar; Skrablin, S.; Fimmers, Rolf; Ven, Katrin van der

doi:10.1016/s0301-2115(03)00314-2

Cited by 23 publications

(9 citation statements)

References 35 publications

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“…Table 2 summarizes the analysis of 23 studies involving 3131 patients and 4036 controls that assessed the association between FVL and all preeclampsia [7]–[10], [19]–[21], [23], [26], [27], [29], [30], [32], [33], [35], [41], [42], [44]–[47], [50], [51]. Meta-analysis revealed a significant association between FVL and preeclampsia (pooled OR = 1.60, 95% CI 1.28–2.00, p = 0.251, I 2 = 15.5%) when a fixed model was applied (Figure 6).…”

Section: Resultsmentioning

confidence: 99%

Association between Thrombophilia Gene Polymorphisms and Preeclampsia: A Meta-Analysis

et al. 2014

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ObjectiveTo estimate the relationship between the risk of preeclampsia and two thrombophilia gene single-nucleotide polymorphisms (SNPs), the factor V G1691A SNP and the prothrombin G20210A SNP.Date SourcesA systematic search of the English-language literature up to November 2012 was performed using Medline and EMBASE. Search terms included “preeclampsia,” “thrombophilia,” “factor V Leiden,” “prothrombin gene 20210,” and their combinations.Result(s)Thirty-seven studies with 5048 preeclampsia patients and 6796 controls were included in the meta-analysis. We found that the prothrombin G20210A polymorphism was associated with an increased risk of all preeclampsia (pooled odds ratio (OR) = 1.81, 95% confidence interval (CI) 1.25–2.63) and severe preeclampsia (pooled OR = 3.02, 95%CI 2.06–4.45). Meanwhile, the pooled OR for the association between factor V Leiden and all preeclampsia was 1.60 (95%CI 1.28–2.00) and 2.45 (95%CI 1.63–3.69) for the cases of severe preeclampsia.Conclusion(s)This meta-analysis supports that the factor V G1691A SNP and the prothrombin G20210A SNP are associated with an increased risk for both preeclampsia overall and severe preeclampsia.

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Section: Resultsmentioning

confidence: 99%

Association between Thrombophilia Gene Polymorphisms and Preeclampsia: A Meta-Analysis

et al. 2014

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“…Seremak-Mrozikiewicz et al [29] in a sample of Polish preeclamptic women observed a significant association between prothrombin G20210A mutation and the development of severe preeclampsia. In another study, Prasmusinto et al [30] examined the frequency of FVL among Germans/Croatia and Indonesian and detected population differences in the association of FVL with increased risk of preeclampsia among Germans/Croatia but not in Indonesian. In two separate meta-analyses by Lin et al [31] and Dudding et al [32] strong association between maternal FVL and preeclampsia appearance is reported.…”

Section: Discussionmentioning

confidence: 99%

Thrombophilic mutations and susceptibility to preeclapmsia in Western Iran

Malek-Khosravi

Rahimi

et al. 2011

J Thromb Thrombolysis

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The aim of the present study was to investigate the frequency and the possible association between thrombophilic mutations of factor V Leiden (FVL) and prothrombin G20210A with preeclampsia among Kurdish population of Western Iran. We studied 198 women with preeclampsia including 128 women with mild and 70 women with severe forms and 101 healthy pregnant women with uncomplicated pregnancy. Among cases there were 23 women with early onset preeclampsia and 175 cases with late-onset preeclampsia. The sample was genotyped by polymerase chain reaction-restriction fragment-length polymorphism using Mnl I and Hind III for FVL and prothrombin G20210A, respectively. The frequency of heterozygous FVL mutation was 7.6% among all preeclamptic women (8.6% in mild and 5.7% in severe preeclamptic women) and 7.9% in controls (P > 0.05). However, the prevalence of heterozygous FVL were 10.5 and 3.9% among severe preeclamptic women with early onset and late-onset preeclampsia, respectively (P > 0.05). The prevalence of prothrombin G20210A were 1.6, 2.9, and 3% among women with mild preeclamsia, severe preeclampsia and controls, respectively (P > 0.05). The level of serum triglycerides (TG) was significantly higher among women with preeclampsia compared to healthy pregnant women that was not associated with the two thrombophilic mutations. Our results indicate that neither FVL nor prothrombin G20210A could be a risk factor for preeclampsia in our population. However, high prevalence of FVL in preeclamptic women with early onset compared to those with late-onset preeclampsia may suggest a role for this mutation in predisposition to early onset preeclampsia that need to be confirmed with larger sample size.

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“…13,14 In fact, different rates of polymorphisms in the methylene tetrahydrofolate reductase 677T and factor V Leiden mutations among white and Indonesian mothers have been demonstrated and showed different associations with developing preeclampsia. 15 However, whether such polymorphisms act differently within different ethnic groups and whether their behavior in the development of preeclampsia is associated with concordance or discordance with the fetus requires further elucidation.…”

Section: Discussionmentioning

confidence: 99%