Ethnic differences in the association between lipid metabolism genes and lipid levels in black and white South African women

Ellman, Nicole; Keswell, Dheshnie; Collins, Malcolm; Tootla, Mehreen; Goedecke, Julia H.

doi:10.1016/j.atherosclerosis.2015.03.027

Cited by 33 publications

(30 citation statements)

References 47 publications

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“…In contrast to the direction of the ancestry differences at LPL reported above, the associations for LPL were significant in black South African women, but not among their white counterparts, despite a larger sample size and a higher prevalence of the variant. Similar interethnic differences were observed for LIPC and CETP [15]. In contrast, associations in these genes in EA and AA have been observed to be broadly similar[78, 84, 87, 88].…”

Section: Genomic Influences On Interethnic Differences In Serum Lipidsmentioning

confidence: 56%

“…However, this difference in distribution is not what is observed among Africans, where the HDLC concentration is more similar to what is observed in European ancestry individuals [12, 13], or lower[14, 15]. It is unclear what leads to this discrepancy between African ancestry individuals in different locations, but it seems reasonable that HDLC is under the influence of an environmental factor that differs between the US and Africa.…”

Section: Interethnic Differences In Serum Lipidsmentioning

confidence: 78%

“…This increased insulin response is associated with greater clearance of free fatty acids, which may contribute to lower constitutive TG levels. There is also some evidence of higher LPL mRNA expression in subcutaneous compared to visceral adipose tissue [41, 42], and differences in distribution of body fat has also been proposed as contributing to higher LPL activity among African ancestry individuals[15]. …”

Section: Physiology Underlying Interethnic Differences In Serum Lipidsmentioning

confidence: 99%

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Interethnic Differences in Serum Lipids and Implications for Cardiometabolic Disease Risk in African Ancestry Populations

Bentley¹,

Rotimi

2017

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African Americans are generally found to have a healthier lipid profile (lower triglycerides [TG] and higher high-density lipoprotein cholesterol concentration [HDLC]) compared to those of other ethnicities. Paradoxically, African Americans do not experience a decreased risk of the cardiometabolic diseases that serum lipids are expected to predict. This review explores this mismatch between biomarker and disease among African ancestry individuals by investigating the presence of interethnic differences in the biological relationships underlying the serum lipids – disease association. This review also discusses the physiologic and genomic factors underlying these interethnic differences. Additionally, because of the importance of serum lipids in assessing disease risk, interethnic differences in serum lipids have implications for identifying African ancestry individuals at risk of cardiometabolic disease. Where possible, data from Africa is included, to further elucidate these ancestral differences in the context of a different environmental background.

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Section: Genomic Influences On Interethnic Differences In Serum Lipidsmentioning

confidence: 56%

Section: Interethnic Differences In Serum Lipidsmentioning

confidence: 78%

Section: Physiology Underlying Interethnic Differences In Serum Lipidsmentioning

confidence: 99%

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Interethnic Differences in Serum Lipids and Implications for Cardiometabolic Disease Risk in African Ancestry Populations

Bentley¹,

Rotimi

2017

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“…Meta-analyses of GWASs among 100,000 individuals of European descent ascertained in the United States, Europe, and Australia, showed 95 significantly associated loci with lipid traits, which in aggregate, may explain 10-12% of the total variance [94] . In individuals of African descent, sequence variants in individual genes shown to be consistently related to blood lipid phenotypes include PCSK9 [95] , C679X [96] , and apolipoprotein E [97] with LDL; LPL , CETP [98] , and apolipoprotein E [97] with HDL-C; and apolipoprotein A5 with triglycerides [99] .…”

Section: Dyslipidemiamentioning

confidence: 99%

Genomics of Cardiometabolic Disorders in Sub-Saharan Africa

Adebamowo¹,

Tekola‐Ayele

Adeyemo

et al. 2017

Public Health Genomics

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Sub-Saharan Africa (SSA) is experiencing a growing burden of cardiometabolic disorders, including diabetes, dyslipidemia, hypertension, obesity, coronary heart disease, and stroke. The increasing trends are expected to accelerate as SSA continues to experience economic progress, population growth, and the shift from communicable to noncommunicable diseases. These complex disorders are caused by multiple, potentially interacting, environmental, and genetic factors. While considerable progress has been made in the identification of the sociocultural, demographic, and lifestyle risk factors for cardiometabolic disorders, many genetic factors that underlie individual susceptibility to these diseases remain largely unknown. Although progress in genomic technologies has allowed for systematic characterization of genome-wide genetic diversity in health and disease in European and Asian ancestry populations, conduct of genetic studies in SSA has been underwhelming until recently. Here, we summarize recent understanding of the body of knowledge and highlight research opportunities on the genomics of cardiometabolic disorders in SSA. Published by S. Karger AG, Basel

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“…It is also well established that the genetic determinants of disorders (including dyslipidemia) are different in various populations and ethnic groups, the characteristics of dyslipidemia and its dominant components varying in different populations [11].…”

Section: Introductionmentioning

confidence: 99%

Relationship of lipid regulatory gene polymorphisms and dyslipidemia in a pediatric population: the CASPIAN III study

et al. 2018

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Objective In this study, we aimed to assess the association between four variants in three genes whose association has been reported in adults but not in children. We evaluated the relationship of the GCKR (rs780094), GCKR (rs1260333), FADS (rs174547), and MLXIPL (rs3812316) polymorphisms with serum lipid levels in Iranian children. Design This cross-sectional study was conducted in a subpopulation of the CASPIAN III study. During this study, 550 frozen whole blood samples were selected randomly. Using the recorded information of selected cases, those with and without abnormal lipid levels were determined. Allelic and genotypic frequencies of GCKR (rs780094), GCKR (rs1260333), MLXIPL (rs3812316), and FADS (rs174547) polymorphisms were determined and compared in dyslipidemic and normal children. The association between the studied polymorphisms and lipid profiles was determined using logistic regression analysis. Results Prevalence of hypercholesterolemia, hypertriglyceridemia, high low-density lipoprotein cholesterol (LDL-C), and low high-density lipoprotein cholesterol (HDL-C) were 24.9, 34.5, 19.0, and 40.7%, respectively. Significant correlations were found between GCKR (rs780094) and GCKR (rs1260333) polymorphisms and cholesterol and triglyceride levels, between FADS (rs174547) polymorphism and level of triglyceride, and also between MLXIPL (rs3812316) and levels of HDL-C. Conclusions The results of this population-based study provide evidence for a relationship between lipid regulatory gene polymorphisms including GCKR (rs780094), GCKR (rs1260333), FADS (rs174547), and MLXIPL (rs3812316) with dyslipidemia in an Iranian population. These results could provide baseline information on as well as further insight into the genetic makeup of lipid profiles in Iranian children, which could be used for preventative strategies.

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Ethnic differences in the association between lipid metabolism genes and lipid levels in black and white South African women

Cited by 33 publications

References 47 publications

Interethnic Differences in Serum Lipids and Implications for Cardiometabolic Disease Risk in African Ancestry Populations

Interethnic Differences in Serum Lipids and Implications for Cardiometabolic Disease Risk in African Ancestry Populations

Genomics of Cardiometabolic Disorders in Sub-Saharan Africa

Relationship of lipid regulatory gene polymorphisms and dyslipidemia in a pediatric population: the CASPIAN III study

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