Ethnic differences in the association of the glutathione S-transferase T1 (GSTT1) null genotype and risk of gastric carcinoma: a systematic review and meta-analysis

Abstract

We performed a systematic review and meta-analysis of the association between the glutathione S-transferase T1 (GSTT1) deletion polymorphism and gastric cancer risk in populations from different ethnic backgrounds, based on a comprehensive literature search of the MEDLINE, EMBASE, and COCHRANE libraries. Thirty-six individual case-control studies comprising 7,689 gastric cancer cases and 12,445 controls were included in our meta-analysis. Overall, the GSTT1 null genotype appeared to increase gastric cancer risk (OR 1.17, 95% CI 1.06-1.31, p = 0.003). While Caucasian populations showed an association between the GSTT1 deletion polymorphism and gastric cancer risk (OR 1.27, 95% CI 1.05-1.52, p = 0.01), Asian populations did not show such an association (p = 0.11). When stratified by quality assessment scores, a significant association between the GSTT1 deletion polymorphism and gastric cancer risk was observed only in the Caucasian high quality subgroup (OR 1.27 95% CI 1.01-1.60, p = 0.05). Null genotypes for both GSTT1 and GSTM1 deletion polymorphisms also increased gastric cancer risk (OR 1.37, 95% CI 1.04-1.80, p = 0.03). Our study suggests that the GSTT1 null genotype is associated with a significant increase in gastric cancer risk in Caucasians, but not in Asians. Further well-designed studies are required to confirm the association between GSTT1 polymorphisms and gastric cancer risk in relation to various clinicopathological factors in different ethnic groups, especially Caucasians.

Polymorphisms of glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) and endometriosis risk: a meta-analysis

“…Marked association of GSTT1 deletion with lung cancer [38] and gastric cancer [39] has Interestingly, our subgroup analysis by ethnicity showed that the GSTT1 polymorphism played different roles in Asian and Caucasian populations. In the Asian population, GSTT1 null genotype was significantly associated with increased endometriosis risk, whereas in Caucasians, no significant correlation has been observed.…”

Complement Receptor 1 Genetic Variants Contribute to the Susceptibility to Gastric Cancer in Chinese Population

“…Over recent years, genome-wide association studies (GWAS) have identified multiple genetic loci associated with gastric cancer risk 23 - 25 . In addition, much effort in case-control studies has been spent in searching for cancer susceptibility genes, such as genes coding for inflammatory mediators 7 , DNA repair 26 , apoptosis 27 and carcinogen metabolism 28 . In a Nature Immunology article, Rutkowski and his colleges reviewed that complement proteins might facilitate the process of carcinogenesis by increasing activity of mitogenic signaling pathways, inducing cellular proliferation, and promoting immunosupression 29 .…”

Intravenous glutathione for skin lightening: Inadequate safety data

“…Of the plethora of articles retrieved from the second MEDLINE search, we identi fied 28 systematic reviews of animal stud ies, [3941] GSHrelated genetic polymorphisms linked to various cancers (colo rectal can cer, [42] leukaemia, [43,44] lung cancer, [45,46] blad der can cer, [47] gastric cancer, [48,49] prostate cancer, [5053] adult brain tumours, [54] basal cell carcinoma [55] ) and linked to other disorders (autism, [12,13] hyper tension, [56,57] respiratory diseases, [58,59] cataract, [60] myelo dysplastic syndrome, [61,62] glioma [63] and male idio pathic infertility. [64] ) There were 9 RCTs identified from two systematic reviews of the use of GSH to reduce chemotherapy induced toxicity (6 cisplatin, 2 axaliplatin, 1 platinum); most suggested less toxicity in GSH groups.…”