Ethnic Differences in HLA Antigens in Chilean Donors and Recipients: Data From the National Renal Transplantation Program

Droguett, M.A.; Beltran, R; Ardiles, R.; Raddatz, Natalia; Labraña, C.; Arenas, A.; Flores, José de Jesús Vargas; Alruiz, P.A.; Mezzano, Sergio; Ardiles, Leopoldo

doi:10.1016/j.transproceed.2008.03.065

Cited by 4 publications

(3 citation statements)

References 9 publications

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“…В Чили был проведен анализ HLA типирования 421876 доноров и реципиентов почек. Установлено, что HLA-В08 значительно чаще выявлялся у реципиентов этнической группы Mapuche, что может рассматриваться как генетический фактор предрасположенности к хронической почечной недостаточности этой этнической группы (у нас он выявлялся у 12,96% пациентов) [37].…”

Section: Discussionunclassified

HLA system features in patients on waiting list for kidney transplantation in the Republic of Bashkortostan

Korzhenevsky

Korzhenevskaya

2022

Med. immunol.

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The aim of our study was to specify the features of the HLA system in patients registered on the waiting list for kidney transplantation in the Republic of Bashkortostan. HLA-A, HLA-B, and HLA-DR phenotypes were assayed by polymerase chain reaction using PROTRANS and OLERUP SSP kits. The frequency of antigen occurence was determined as the percentage of individuals with the given antigen to the total number of examined individuals. To determine the patterns of distinct antigens within various HLA combinations, we determined maximal percentage of the antigen frequency in combination with other HLA. The largest number of patients on the waiting list suffered from chronic glomerulonephritis, followed by diabetes mellitus, chronic interstitial nephritis, chronic pyelonephritis and polycystic kidney disease. The occurrence frequency of various HLA and their combinations was established both among all the patients suffering from stage 5 chronic kidney disease, and among patients with regard to each nosological category, and the patterns of various HLA combinations were established. The data obtained have been compared with the study results of patients from the waiting lists for organ transplantation in other regions. HLA-A02 (similar to Brazil, Great Britain), HLA-DR07, HLA-DR04 (like as in Nepal, European population of Kazakhstan, Southern China), HLA-A24 (as in Nepal, Southern China), and combinations of HLA-A02-A03, HLA-A02-DR04, HLA-A02-DR01, HLA-A02-B07, HLA-A03-DR01, HLA-B35-DR01 were most common in the patients with chronic kidney disease which can be considered as risk factor for severe nephropathy. HLA-B15, HLA-B40, HLA-vA30, HLA-A32, HLA-B56, HLA-B60, HLA-DR10 were found at minimal frequency; as well as the following combinations: HLA-A01-A24-B08-DR17, HLA-A01-A68-DR07, HLAA24-B07-B13, HLA-A01-B08-B13, HLA-A02-B35-B38-DR01, HLA-A02-B50-B61-DR07, HLA-A01-B55-DR04, HLA-A02-B55-DR03, HLA-A24-B55-DR13, HLA-A01-A02-B08-DR03, HLA-A02-DR01-DR13. The following antigens were absent among our patients: HLA-A28 (similar to Kuwait); HLA-A11, HLA-A23, HLA-A28, HLA-A33, HLA-B46, HLA-B62;-DR03, HLA-DR14 (as in Kazakhstan); HLAA19, HLA-A43, HLA-B16, HLA-B21, HLA-B22, HLA-B83 and HLA-DR05 (as in Great Britain); HLAB14 (as in Brazil). The results obtained were either similar, or different from the literature data, both in terms of the most common HLA and their combinations with regard of special nephropathy types. The revealed differences can be explained by presence of population-specifical HLA features in the patients from different ethnic groups and living in different geographical areas. The found stable associative links between the disorders and HLA may contribute to better understanding of pathogenesis of the disorders, their early preclinical detection, evaluating risk for development of pathological conditions, thus allowing timely justification of preventive measures.

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Section: Discussionunclassified

HLA system features in patients on waiting list for kidney transplantation in the Republic of Bashkortostan

Korzhenevsky

Korzhenevskaya

2022

Med. immunol.

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“…El diagnóstico de EB no es fácil, en un estudio hecho en Turquía el lapso promedio fue 6,6 años entre la primera manifestación y el diagnóstico de EB, estas dificultades podrían ser mayores en otras regiones en que las manifestaciones típicas son diferentes y la enfermedad menos frecuente 5 . En este caso apoya el diagnóstico el que la paciente es HLA B51 positivo, tradicionalmente descrito en pacientes de origen oriental y asociado con el compromiso ocular 6,10 , sin embargo, la frecuencia de HLA B5 que incluye las especificidades B51 y B52 es 19% en población chilena, en un estudio que comprendió 1.297 donantes o receptores de órganos 11 . Las lesiones cutáneas son comunes en la EB entre 41% y 97% de los estudios, y para Schirmer y col 5 estarían sobre representadas en los criterios ISG.…”

Section: Discussionunclassified

Trombosis de senos venosos encefálicos como posible primera manifestación de enfermedad de Behçet: Caso clínico

et al. 2010

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“…In Chile, the prevalence and incidence of SpA is unknown, but we know that between 2% and 3% of the population possesses the histocompatibility antigen HLA B27 (+), [5][6][7] which plays an important role in the disease. 8 The most up-to-date data in South America estimates a SpA prevalence of 0.52, for ankylosing spondylitis (AS) of 0.14, and for psoriatic arthritis (PsA) of 0.07.…”

Section: Epidemiologymentioning

confidence: 99%

Spondyloarthritis in Chile

Ibáñez

Valenzuela²

2018

J Clin Rheumatol

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Ethnic Differences in HLA Antigens in Chilean Donors and Recipients: Data From the National Renal Transplantation Program

Cited by 4 publications

References 9 publications

HLA system features in patients on waiting list for kidney transplantation in the Republic of Bashkortostan

HLA system features in patients on waiting list for kidney transplantation in the Republic of Bashkortostan

Trombosis de senos venosos encefálicos como posible primera manifestación de enfermedad de Behçet: Caso clínico

Spondyloarthritis in Chile

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