Ethnic differences in asthma and associated phenotypes: Collaborative Study on the Genetics of Asthma

Lester, Lucille A.; Rich, Stephen S.; Blumenthal, Malcolm N.; Togias, Alkis; Murphy, Shirley; Malveaux, Floyd J.; Miller, Michael E.; Dunston, Georgia M.; Solway, Julian; Wolf, Raoul L.; Samet, Jonathan M.; Marsh, David G.; Meyers, Deborah A.; Ober, Carole; Bleecker, Eugene R.

doi:10.1067/mai.2001.117796

Cited by 97 publications

(88 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The average age (6 SD) of offspring with asthma was 21.8 6 13.23 years in the African Caribbean families, 14.6 6 7.7 years in the African American families, 20.0 6 10.8 years in the European American families, 23.27 6 17.03 years in the Brazilian families, and 17.54 6 10.1 years in the Colombian families. Among African Caribbean, African American, and European American family members (745, 368, and 494 individuals, respectively), means of tIgE concentrations were similar to those described previously (23,29,30). In general, tIgE levels were significantly different between founders in each pair of populations except for the comparison of African American and European American populations (P 5 0.161).…”

Section: Demographic Characteristicssupporting

confidence: 57%

Gene Encoding Duffy Antigen/Receptor for Chemokines Is Associated with Asthma and IgE in Three Populations

Vergara¹,

Tsai²,

Grant³

et al. 2008

Am J Respir Crit Care Med

View full text Add to dashboard Cite

Rationale: Asthma prevalence and severity are high among underserved minorities, including those of African descent. The Duffy antigen/receptor for chemokines is the receptor for Plasmodium vivax on erythrocytes and functions as a chemokine-clearing receptor. Unlike European populations, decreased expression of the receptor on erythrocytes is common among populations of African descent, and results from a functional T-46C polymorphism (rs2814778) in the promoter. This variant provides an evolutionary advantage in malaria-endemic regions, because Duffy antigen/receptor for chemokines-negative erythrocytes are more resistant to infection by P. vivax. Objectives: To determine the role of the rs2814778 polymorphism in asthma and atopy as measured by total serum IgE levels among four populations of African descent (African Caribbean, African American, Brazilian, and Colombian) and a European American population. Methods: Family-based association tests were performed in each of the five populations to test for association between the rs2814778 polymorphism and asthma or total IgE concentration. Measurements and Main Results: Asthma was significantly associated with the rs2814778 polymorphism in the African Caribbean, Colombian, and Brazilian families (P , 0.05). High total IgE levels were associated with this variant in African Caribbean and Colombian families (P , 0.05). The variant allele was not polymorphic among European Americans. Conclusions: Susceptibility to asthma and atopy among certain populations of African descent is influenced by a functional polymorphism in the gene encoding Duffy antigen/receptor for chemokines. This genetic variant, which confers resistance to malarial parasitic infection, may also partially explain ethnic differences in morbidity of asthma.

show abstract

Section: Demographic Characteristicssupporting

confidence: 57%

Gene Encoding Duffy Antigen/Receptor for Chemokines Is Associated with Asthma and IgE in Three Populations

Vergara¹,

Tsai²,

Grant³

et al. 2008

Am J Respir Crit Care Med

View full text Add to dashboard Cite

show abstract

“…This hypothesis is based on data obtained from epidemiological studies of tropical diseases, data on the relative prevalence of inflammatory alleles in different populations, and data on disease patterns among immigrant populations. For example several studies, both molecular and epidemiological, have shown that atopic disorders are more common in African-Americans than in white Americans (150,151). A prediction that follows from these data is that also native Europeans have a lower genetic risk of atopic disease than immigrant populations originating in the Tropics.…”

Section: Gene-environment Interactionsmentioning

confidence: 99%

Asthma and atopy – the price of affluence?

Hertzen

Haahtela²

2004

Allergy

121

110

View full text Add to dashboard Cite

Irrespective of improved knowledge of many aspects of atopic diseases, the unfavorable trends in their prevalence particularly among children could not have been reversed. A growing body of evidence suggests that something may lack from our societal affluence that has the capacity to provide protection against the development of atopic diseases. Much attention during the last years has been devoted to the hygiene hypothesis. This review outlines the impact of environment and lifestyle, particularly from the perspective of the East–West gradient, on the development of atopic diseases, with a special emphasis on the hygiene hypothesis in its broadest sense.

show abstract

“…15 To be included in these studies, each of the two asthmatic siblings had to have met the following criteria: (1) at least 6 years of age; (2) either bronchial hyper-responsiveness, defined as a fall in baseline FEV1 greater than 20% in 1 s after inhalation of less than 25 mg/ml methacholine, or reversibility, defined as a greater than 15% increase in baseline FEV1 after inhaled bronchodilator (albuterol) for those with reduced baseline FEV1; (3) presence of two or more of the symptoms of coughing, wheezing and shortness of breath; (4) less than three pack-years of cigarette smoking; and (5) physician's diagnosis of asthma with no conflicting pulmonary disease. All family members were evaluated for asthma using identical protocols.…”

Section: Family Ascertainmentmentioning

confidence: 99%

“…15,16 Briefly, families were ascertained at four centers-Johns Hopkins University (Baltimore, USA) with Howard University (Washington, DC, USA); the University of Chicago; the University of Maryland (Baltimore, USA) with the University of New Mexico; and the University of Minnesota. Families were ascertained through two asthmatic siblings, and were expanded to include other relatives either by extending the family through asthmatic relatives or through no more than one unaffected relative (to include other asthmatic relatives).…”

Section: Family Ascertainmentmentioning

confidence: 99%

Genome scan for loci linked to mite sensitivity: the Collaborative Study on the Genetics of Asthma (CSGA)

Ober²,

Beaty

et al. 2004

Genes Immun

View full text Add to dashboard Cite

Ethnic differences in asthma and associated phenotypes: Collaborative Study on the Genetics of Asthma

Cited by 97 publications

References 32 publications

Gene Encoding Duffy Antigen/Receptor for Chemokines Is Associated with Asthma and IgE in Three Populations

Gene Encoding Duffy Antigen/Receptor for Chemokines Is Associated with Asthma and IgE in Three Populations

Asthma and atopy – the price of affluence?

Genome scan for loci linked to mite sensitivity: the Collaborative Study on the Genetics of Asthma (CSGA)

Contact Info

Product

Resources

About