Ethnic difference of<i>Helicobacter pylori</i>gastritis: Korean and Japanese gastritis is characterized by male- and antrum-predominant acute foveolitis in comparison with American gastritis

Lee, Inchul

doi:10.3748/wjg.v11.i1.94

Cited by 30 publications

(22 citation statements)

References 27 publications

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“…We found a reduced risk for gastritis in subjects carrying the T1 haplotype. The reason is that the homozygous state (IL-1RN 1/1) or IL1RN*1 allele in combination with the IL-1B *T allele is associated with higher levels of IL-1Ra in vitro and thus individuals with higher levels of IL-1Ra may be protected against the pro-inflammatory effects of the IL-1 cytokine [25]. Furthermore, the frequency of T1 haplotype is ~48%, higher than the frequency of the IL-1RN 1/2 genotype (26%) in our control population.…”

Section: Discussionmentioning

confidence: 98%

“…Current evidence suggests that the IL-1 cytokine family is a complex self-regulating system; its members have been proposed as candidate genes in inflammatory disorders [25][26][27]. In the present study, we have evaluated the association of IL-1B (-511 C/T) and IL-1RN (VNTR) polymorphisms with alleles, genotypes and haplotypes in gastritis patients and healthy controls.…”

Section: Discussionmentioning

confidence: 98%

“…A 50 base-pair marker was included during electrophoresis. Twenty percent of samples from patients and controls including each genotype were re-genotyped by other laboratory person- 25 Clin Exp Med (2008) 8: [23][24][25][26][27][28][29] nel; no discrepancy was found even after sequencing the randomly selected 5% samples.…”

Section: Quality Controlmentioning

confidence: 99%

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Genetic association of interleukin-1 haplotypes with gastritis and precancerous lesions in North Indians

2008

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 98%

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Genetic association of interleukin-1 haplotypes with gastritis and precancerous lesions in North Indians

2008

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“…A hypothesis for these associations, although not explored in the present study, is that male patients may have a higher frequency of Helicobacter pylori, which is strongly associated with higher prevalence of gastritis in the antral region. [25][26][27] …”

Section: ■ Conflict Of Interestmentioning

confidence: 99%

Morphological alterations of upper gastrointestinal tract in patients with new onset-dermatomyositis: correlation with demographic, clinical and laboratory features

Amorim¹,

Furuya²,

Marques³

et al. 2017

Medical Express

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OBJECTIVE:To endoscopically assess the upper digestive tract of adult patients with newly diagnosed dermatomyositis; to correlate possible changes in the gastrointestinal tract with demographic, clinical and laboratory features in this population. METHOD: A cross-sectional study evaluating 65 newly diagnosed dermatomyositis cases from 2004 to 2015 was carried out. We excluded patients with clinically amyopathic dermatomyositis, overlap dermatomyositis, polymyositis, liver diseases, prior gastric surgery, upper gastrointestinal tract symptoms (except for upper dysphagia), systemic infections, alcohol consumption and smoking. RESULTS: Mean age of patients was 44.9 years, with disease duration of four months. Endoscopic findings were observed in 70.8% of patients. (1) Esophageal disease/gastric distress was documented in 18.5% of patients: erosive distal esophagitis (16.9%) and non-erosive distal esophagitis distal (1.5%); (2) gastric distress in 63.1% of cases: antral gastritis (42.3%) and pangastritis (27.8%); (3) duodenal involvement in 15.4% of patients: bulbar duodenitis (10.9%) and duodenal ulcers (7.7%). There were no neoplasic lesions. On multivariate analysis, erosive distal esophagitis was less associated with older patients. Males had a higher prevalence of erosive gastritis. Enanthematous pangastritis was less associated with lesions with "V-neck" sign lesions. CONCLUSIONS: This study provides the first estimates of the prevalence of high endoscopic findings in adult patients with newly diagnosed dermatomyositis. The results may be relevant to guide conduct in digestive disorders with upper digestive endoscopy, and point to the need for pharmacological prevention of digestive tract lesions in these patients. Further studies are needed to validate this data and evaluate patients with dyspeptic symptoms.

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“…Gastric ulcer (GU) patients had more atrophy and intestinal metaplasia in the antrum and corpus than DU patients [19]. In Hp -positive nonulcer patients, neutrophilic folliculitis, intestinal metaplasia and atrophy in the antrum but not corpus were more frequent in Koreans and Japanese than Americans [20]. Comparing gastritis of different age cohorts of UK and Japanese nonulcer dyspepsia patients, corpus predominant gastritis or pangastritis in Japanese patients was more common, and atrophy and intestinal metaplasia more extensive and severe [21].…”

Section: Comparisons Of Eastern With Western Gastritismentioning

confidence: 99%

Different Pathophysiology of Gastritis in East and West? A Western Perspective

Wirth¹,

Yang²

2016

Inflamm Intest Dis

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Background: Gastritis results from multifactorial gastric mucosal injury. Helicobacter pylori(Hp) is the main cause, and associated diseases have typical underlying patterns of gastritis. Gastric ulcer and gastric cancer (GC) develop from chronic atrophic corpus gastritis (CAG) which therefore represents the most important pattern. GC incidences in East Asia are substantially higher than elsewhere, and this should be also reflected by higher prevalences of CAG and characteristic differences in pathophysiology compared to the West. Summary: The few available comparative studies of gastritis in Eastern and Western patients are summarized. The main pathogenic factors of gastritis are discussed together with their limitations to explain local differences in disease outcome. Emphasis was put to also include less well-established pathogenic host and environmental factors of possible impact. Conclusions: CAG is more prevalent in East Asian areas with high GC incidences than the West. Geographic heterogeneity of associated diseases is due to differences in Hp prevalence and virulence as well as modulating host and environmental factors. The following may contribute to the higher burden of CAG in the East: ABD type of CagA with vacA s1 and babA2 alleles of Hp, host Lewis(b) expression in sej/sej nonsecretors, H. heilmannii, low parietal cell mass, high sodium and nitrate intake, preferences in vegetable and fruit consumption, cigarette smoking, air pollution, alcohol. Conversely, green tea, nonfermented soy products and rice may confer protective effects. Hp is on the decline, but also in a world cleared from this bacterium, differences in host genetics will continue to modify gastric disease outcome together with maintained customs as part of cultural diversity.

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Ethnic difference ofHelicobacter pylorigastritis: Korean and Japanese gastritis is characterized by male- and antrum-predominant acute foveolitis in comparison with American gastritis

Cited by 30 publications

References 27 publications

Genetic association of interleukin-1 haplotypes with gastritis and precancerous lesions in North Indians

Genetic association of interleukin-1 haplotypes with gastritis and precancerous lesions in North Indians

Morphological alterations of upper gastrointestinal tract in patients with new onset-dermatomyositis: correlation with demographic, clinical and laboratory features

Different Pathophysiology of Gastritis in East and West? A Western Perspective

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