Ethnic and sex differences in the total and differential white cell count and platelet count.

Abstract

Conclusions-Sex and ethnic origin should be taken into consideration when assessing white cell and platelet counts. (7 Clin Pathol 1996;49:664-666)

Lymphocyte subset reference intervals in blood donors from northeastern Brazil

“…An assessment of the degree of populational mixing in Salvador indicated that this population follows a tri-hybrid model of ancestral contribution: 49% African, 44% European and 7% Amerindian (Felix et al 2010) Interestingly, the elevated degree of mixing seems to have had no influence on leucocyte reference intervals or lymphocytes subset reference intervals. Although a smaller number of leukocytes has been described in populations of African descent in comparison to Caucasians (Forbes et al 1941, Rippey 1967, Bain 1996, Pancham et al 1999) similar values were observed in Brazilian blood donors from Salvador, as well as in reference values provided by two laboratories in São Paulo and Rio de Janeiro, cities with populations containing higher proportions of Caucasians (data not shown) than Salvador.…”

Congenital and acquired neutropenia consensus guidelines on diagnosis from the Neutropenia Committee of the Marrow Failure Syndrome Group of the AIEOP (Associazione Italiana Emato‐Oncologia Pediatrica)

“…In Blacks of South African extraction [13] (II), in American Mexicans [14] (I), in Afro Caribbean [15] (I), in Yemenite Jews ancestries and in some Arabic ethnicity [13][14][15][16] (II) an ANC between 0.5 and 1.0 Â 10 9 /L mainly if not associated to infections and found also in the parents, was considered to allow the diagnosis of the Ethnic neutropenia which is considered a variation from the normal [17] (V, EO, 8.7, B).…”

Quantification of biological variation in blood‐based therapy – a summary of a meta‐analysis to inform manufacturing in the clinic

“…Intra‐individual or ‘Within‐Person’ Variation – This is the effect of changes within a specific donor due to certain internal or external circumstances, such as changes in blood composition due to seasonality, circadian rhythm, exercise, extent of specific illnesses and the particular method of isolating the raw material 7, 8.Inter‐individual or – ‘Between‐Person – This is the most visually apparent of sources and concerns the differences between individuals such as age, weight, lifestyle choice and ethnicity 9, 10, 11. The scarcity of donor interindividual variables meant that these were grouped together, which may add to the overall variation found in Fig.…”

“…Inter‐individual or – ‘Between‐Person – This is the most visually apparent of sources and concerns the differences between individuals such as age, weight, lifestyle choice and ethnicity 9, 10, 11. The scarcity of donor interindividual variables meant that these were grouped together, which may add to the overall variation found in Fig.…”