Ethics Pertaining to the Use of Aborted Human Tissues for Research and Therapeutic Purposes

Sengupta, Priyadarshi; Bhattacharya, Niranjan; Bhattacharya, Sanjukta; Stubblefield, Phillip G.

doi:10.1007/978-3-319-14874-8_48

Cited by 2 publications

(2 citation statements)

References 4 publications

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“…FSCs, similarly, are significantly more multipotent than their adult counterparts [ 6 ]. However, the relatively limited accessibility and ethical controversies associated with employing embryonic or fetal tissue has restricted their use in stem cell research and limited their potential use in tissue engineering and regenerative medicine [ 7 ]. Thus, finding an alternative source of stem/progenitor cells that share features comparable to those of fetal stem cells is crucial.…”

Section: Introductionmentioning

confidence: 99%

Hiding in Plain Sight: Human Gingival Fibroblasts as an Essential, Yet Overlooked, Tool in Regenerative Medicine

Fadl

Leask

2023

Cells

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Adult human gingival fibroblasts (HGFs), the most abundant cells in the oral cavity, are essential for maintaining oral homeostasis. Compared with other tissues, adult oral mucosal wounds heal regeneratively, without scarring. Relative to fibroblasts from other locations, HGFs are relatively refractory to myofibroblast differentiation, immunomodulatory, highly regenerative, readily obtained via minimally invasive procedures, easily and rapidly expanded in vitro, and highly responsive to growth factors and cytokines. Consequently, HGFs might be a superior, yet perhaps underappreciated, source of adult mesenchymal progenitor cells to use in tissue engineering and regeneration applications, including the treatment of fibrotic auto-immune connective tissue diseases such as scleroderma. Herein, we highlight in vitro and translational studies that have investigated the regenerative and differentiation potential of HGFs, with the objective of outlining current limitations and inspiring future research that could facilitate translating the regenerative potential of HGFs into the clinic.

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Section: Introductionmentioning

confidence: 99%

Hiding in Plain Sight: Human Gingival Fibroblasts as an Essential, Yet Overlooked, Tool in Regenerative Medicine

Fadl

Leask

2023

Cells

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“…Hence, they could be ideal candidate for regenerative medicine (Ishii and Eto 2014;Nasli-Esfahani et al 2015a, b). However, the use of fetal tissues have some restrictions and also some ethically and legally deficiencies (Sengupta et al 2016). Therefore, in order to overcome these limitations, alternative sources have been nominated by investigators.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic abortion and ectopic pregnancy: alternative sources for fetal stem cell research and therapy in Iran as an Islamic country

et al. 2018

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Regenerative medicine as a background of stem cell research and therapy has a long history. A wide variety of diseases including Parkinson's disease, heart diseases, multiple sclerosis, spinal cord injury, diabetes mellitus and etc. are candidate to be treated using different types of stem cells. There are several sources of stem cells such as bone marrow, umbilical cord, peripheral blood, germ cells and the embryo/fetus tissues. Fetal stem cells (FSCs) and embryonic stem cells (ESCs) have been described as the most potent stem cell source. Although their plurior multipotent properties leads to promising reports for their clinical applications, owning to some ethical and legal obstacles in different communities such as Muslim countries, care should be taken for therapeutic applications of FSCs and ESCs. Derivation of these cell types needs termination of pregnancy and embryo or fetus life that is prohibited according to almost all rules and teaches in Muslim communities. Abortion and termination of pregnancy under a normal

show abstract

Ethics Pertaining to the Use of Aborted Human Tissues for Research and Therapeutic Purposes

Cited by 2 publications

References 4 publications

Hiding in Plain Sight: Human Gingival Fibroblasts as an Essential, Yet Overlooked, Tool in Regenerative Medicine

Hiding in Plain Sight: Human Gingival Fibroblasts as an Essential, Yet Overlooked, Tool in Regenerative Medicine

Therapeutic abortion and ectopic pregnancy: alternative sources for fetal stem cell research and therapy in Iran as an Islamic country

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