Ethics of HIV trials

Aaby, Péter; Babiker, Abdel; Darbyshire, Janet; Nunn, Andrew; Barreto, Sandhi Maria; Alonso, Pedro L.; Badaro, Roberto; Barms, Fernando C.; Victoria, Cesar G.; Binka, Fred; Biryahwaho, Benon; Byabainazima, Charles; Sempala, S.K.; Tuguine, Benon; Kalebu, Pontiano; Kengeya-Kayondo, Jane F.; Whitworth, Jimmy; Paxton, Lynn A.; Convit, J; Corrah, Tumani; McAdam, Keith; Datta, Manjula; Dowlati, Yahya; Fine, Paul V. A.; Hall, Andy; Hayes, Richard; Jaffar, Shabbar; Ross, David A.; Smith, P. G.; Francisco, Andreas de; Godal, Tore; Jacob, John Roshan; Lansang, Mary Ann; Tan-Torres, Tessa; Morrow, Richard H.; Nicoll, A; Peckham, Catherine; Sánchez‐Oliva, David; Tanner, Marcel

doi:10.1016/s0140-6736(97)26047-2

Cited by 9 publications

(4 citation statements)

References 3 publications

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“…First, biomedical codes of conduct have not eliminated exploitation. Deficient global jurisdiction (Benatar, 2002; Nicoll, 1999) creates loopholes (Angell, 1997; Nuffield Council on Bioethics, 1999, 2002), especially in developing countries: Informed consent, for instance, has not been deemed necessary in countries that have an absence of codes (Aaby et al, 1997; Connor et al, 1994; Lurie & Wolfe, 1997).…”

Section: Discussionmentioning

confidence: 99%

Doing the Right Thing or Doing the Thing Right

Thorpe

2014

Organizational Research Methods

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This article discusses implications of participant withdrawal for inductive research. I describe and analyze how a third of my participants withdrew from a grounded theory study. I position my example, ensuing issues, and potential solutions as reflective of inductive methodologies as a whole. The crux of the problem is the disruption inflicted by withdrawal on inductive processes of generating knowledge. I examine the subsequent methodological and ethical issues in trying to determine the best course of action following withdrawal. I suggest three potential options for researchers: Continuing the study with partial data, continuing the study with all data, and discontinuing the study. Motivated by my experience, and wider theoretical considerations, I present several suggestions and questions, with the aim of supporting researchers in determining the best course of action for their individual field circumstances.

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Section: Discussionmentioning

confidence: 99%

Doing the Right Thing or Doing the Thing Right

Thorpe

2014

Organizational Research Methods

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“…14 However, the standardisation would have inhibited HIV research in Africa and was opposed by global health researchers. 15 This enabled the research to be conducted quickly and at relatively low cost, and research on the prevention and management of diabetes and hypertension may need similar considerations. Thus, although not ideal, priority of medicines for research subjects will be essential in some settings where the supply of medicines cannot be strengthened for all.…”

Section: Is There An Obligation To Provide Medicines To Non-trial Parmentioning

confidence: 99%

Ethical issues in intervention studies on the prevention and management of diabetes and hypertension in sub-Saharan Africa

et al. 2020

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“…The globalization of biomedical research -purportedly guided by ethical principles established in developed countries -has led to numerous controversies and ethical dilemmas [7]. For example, the use of placebo controls in clinical trials for preventing perinatal HIV transmission provoked an intense debate concerning issues of research design, exploitation and fairness, and the relationship between a clinical investigator and a human subject [7][8][9]. This debate involved not only procedural and regulatory questions, such as those related to implementing research protocols or documenting consent, but also deeper questions concerning the social, cultural, and philosophical foundations of research.…”

Section: Introductionmentioning

confidence: 99%

International Biomedical Research and Research Ethics Training in Developing Countries

Mzayek¹,

Resnik²

2010

J Clinic Res Bioeth

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Developing an ethical framework for international biomedical research that is receptive to different cultural norms and moral values requires continuous and earnest dialogue between scientists from developed and developing countries. Adequate and sustainable training programs in biomedical research ethics for scientists from developing countries are essential to prepare competent partners from developing countries in this dialogue.

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Ethics of HIV trials

Cited by 9 publications

References 3 publications

Doing the Right Thing or Doing the Thing Right

Doing the Right Thing or Doing the Thing Right

Ethical issues in intervention studies on the prevention and management of diabetes and hypertension in sub-Saharan Africa

International Biomedical Research and Research Ethics Training in Developing Countries

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