Ethically Advancing Pediatric Cardiac Xenotransplant

Hurst, Daniel J.; Padilla, Luz

doi:10.1001/jamapediatrics.2023.4681

Cited by 4 publications

(2 citation statements)

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“…Acceptance also fell (to 35%) even if the xenograft was considered to be a "bridge" to allotransplantation, i.e., a temporary therapy to help a patient survive for a relatively short period of time (weeks or months) until a deceased human organ becomes available. This concept of "bridging" is particularly relevant to babies born with complex congenital heart disease (i.e., born with an abnormal heart structure) for whom no truly successful therapy may be available [22]. In these babies, the transplantation of a human heart (allotransplantation) is followed by very successful outcomes, but it may be several months before a heart from a suitablesized deceased human donor becomes available (during which period the patient may not survive).…”

Section: Review Of Current Public Engagementmentioning

confidence: 99%

“…This concept of “bridging” is particularly relevant to babies born with complex congenital heart disease (i.e., born with an abnormal heart structure) for whom no truly successful therapy may be available [ 22 ]. In these babies, the transplantation of a human heart (allotransplantation) is followed by very successful outcomes, but it may be several months before a heart from a suitable‐sized deceased human donor becomes available (during which period the patient may not survive).…”

Section: Review Of Current Public Engagementmentioning

confidence: 99%

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The importance of public engagement in clinical xenotransplantation

Hurst,

Cooper

2024

Health Care Science

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Over the past several decades, significant scientific progress in xenotransplantation has brought the field to the threshold of clinical trials. In the past 3 years in the United States, experimental pig kidney and heart xenotransplantation have been performed on human subjects recently declared dead by neurological criteria (decedents). In addition, two pig heart transplants have been carried out in living patients under the United States Food and Drug Administration's expanded access guidelines. However, though there has been a flurry of activity there remain unanswered questions regarding how the public views xenotransplantation, what concerns may exist, and how to address these concerns in a meaningful way. This paper aims to underscore the importance of public engagement in xenotransplantation, emphasizing the ongoing need for studies to assess public opinions. The current evidence on public engagement studies is reviewed and gaps in our understanding are identified. We propose practical steps to advance this field. Additional studies to determine the extent of racial/ethnic differences in attitudes to xenotransplantation should be conducted. Empirical and descriptive analysis of certain religious viewpoints—especially minority faiths—would be valuable. As public engagement is an important aspect of public acceptance of novel research that is accompanied by risk, we suggest that xenotransplantation biotechnology companies might consider leading the way in funding this research.

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Section: Review Of Current Public Engagementmentioning

confidence: 99%

Section: Review Of Current Public Engagementmentioning

confidence: 99%