“…In the context of secondary findings from diagnostic exome or genome sequencing, the American College of Medical Genetics and Genomics (ACMG) proposed disclosing genomic variants that confer risk for diseases with well‐established effective medical interventions (i.e., medically actionable results) (Green et al, 2013; Kalia et al, 2017). However, no such formal guidance exists for the research setting, despite a growing consensus to report results that may impact clinical care (Botkin, Mancher, Busta, & Downey, 2018; Knoppers, Zawati, & Senecal, 2015; Saelaert, Mertes, Moerenhout, De Baere, & Devisch, 2020). Furthermore, as more research groups push to sequence larger and more inclusive cohorts (Ilori et al, 2020; Mapes et al, 2020; Van Hout et al, 2020), there is a growing need for guidance on how to accurately and efficiently identify and report clinically relevant findings to research participants.…”