Ethical issues of diagnosis <i>in utero</i>

Perrotti, Maria Regina Machado; Mandell, James; Mandell, Valerie S.

doi:10.1111/j.1464-410x.1995.tb07877.x

Cited by 2 publications

(4 citation statements)

References 28 publications

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“…Knowledge of the clinical course of a disease becomes particularly important in decisions regarding the best management. Management options for the fetus with hydronephrosis range from observation, with definitive evaluation at birth, to prenatal surgical intervention [6]. Other approaches to management are induction of premature labor to allow early correction of the anomaly and termination of pregnancy.…”

Section: Discussionmentioning

confidence: 99%

“…In the laboratory stratum, two variables were independently associated with adverse outcome: urea higher than 25 mg/dl (hazard =13.9, CI95% =2.8-67) and glomerular filtration rate lower than 20 ml/min (hazard =6.5, CI95% =2. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19].…”

Section: Multivariate Analysismentioning

confidence: 99%

“…[3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19], prematurity (hazard =3.8, CI95% =1. [2][3][4][5][6][7][8][9][10][11], and glomerular filtration rate lower than 20 ml/min (hazard =6.3, CI95% =1.7-23). Table 2 shows the final model with the three variables that remained as independent predictors of death or chronic renal failure in patients with fetal hydronephrosis.…”

Section: Multivariate Analysismentioning

confidence: 99%

“…The physician should explain to the family the possible implications of the prenatal ultrasound findings and propose the best approach to management. The medical team must have knowledge of the prognostic significance of findings associated with prenatally detected hydronephrosis [6]. Therefore, accurate prediction of infants with a poor outcome is highly desirable.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic factors in fetal hydronephrosis: a multivariate analysis

Oliveira

Diniz

Cabral

et al. 1999

Pediatric Nephrology

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With the increasing use of obstetric echography fetal hydronephrosis has been reported more frequently. The purpose of this study was to identify prognostic factors associated with adverse outcome, such as renal failure and death, in fetal hydronephrosis. One hundred and forty-eight children with fetal hydronephrosis were admitted, submitted to a systematic protocol, and prospectively followed. Prognostic factors associated with fetal echography and clinical and laboratory findings on admission were studied. The median follow-up was 39 months. The analysis was conducted in two steps. In a univariate analysis, variables associated with adverse outcome were identified by the Kaplan-Meier method. The variables that were significantly associated with adverse outcome were then included in a multivariate analysis. This analysis, using the multivariate Cox's model, was performed to identify variables that were independently associated with a worse prognosis. Only variables that remained independently associated with adverse outcome were included in the final model. After final adjustment by Cox's multivariate model, three variables were identified as independent predictors of adverse outcome: oligohydramnios, prematurity, and glomerular filtration rate lower than 20 ml/min. Thus, in the presence of oligohydramnios, prematurity, and abnormal renal function, the medical team must plan appropriate follow-up for infants at health centers prepared to investigate and treat uropathies in newborns.

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Section: Discussionmentioning

confidence: 99%